CV Brooke

CURRICULUM VITAE

Updated: November, 2001

BROOKE TAYLOR MOSSMAN

Business address: Professor of Pathology, University of Vermont
College of Medicine, 89 Beaumont Avenue
Burlington, VT 05405

Education: MS University of Vermont, Physiology & Biophysics, 1970
PhD University of Vermont, Cell Biology, 1977

Fields of Specialization:

Environmental toxicology, epithelial cell differentiation, chemical and physical carcinogenesis and cell injury, pulmonary fibrosis, oxygen free radicals, molecular biology of antioxidant enzymes in lung, cell signalling

Career Appointments

1995 - Director, Environmental Pathology Program, University of Vermont
1995 - 1998 Program Leader, Cell Signaling and Growth Control Research Program, Vermont Cancer Center
1992 - Professor, Department of Pathology, University of Vermont
1989 - Adjunct Faculty Member, In Vitro Cell Biology and Biotechnology Program, State University of New York, Plattsburgh, NY
1984 - 1992 Associate Professor, Department of Pathology, University of Vermont
1984 - 1988 Chair, Cell and Molecular Biology Program, University of Vermont
1981 - 1982 University of Vermont Medical Scholar Award "for outstanding and sustained research and scholarly contributions to both the academic disci-pline and the life of the University of Vermont"
1980 - 1983 Assistant Professor, Department of Pathology, University of Vermont
1978 - 1980 Research Assistant Professor, Department of Pathology, University of Vermont
1975 - 1977 Research Associate, Department of Pathology, University of Vermont
1973 - 1974 Research Assistant, Department of Pathology, University of Vermont
1970 - 1973 Research Assistant, Institute of Environmental Medicine, New York Univ, Sterling Forest, NY
1968 - 1970 Research Assistant, Department of Obstetrics & Gynecology, University of Vermont
1968 - 1970 Graduate Student, Physiology and Biophysics, University of Vermont

International Invitations/Honors:

Invited Participant, International Workshop on Effects of Mineral Dusts In Vitro, MRC Pneumoconiosis Unit, Cardiff, Wales, September, 1979
Invited Participant, Conference on Epidemiological, Immunological Genetical Aspects of Asbestosis, Wroclaw, Poland, March, 1981
Invited Participant, 2nd International Workshop on Effects of Mineral Dusts In Vitro, NCTR, Little Rock, Arkansas, April, 1982
Member, National Academy of Sciences Committee, "Non-Occupational Health Risks of Asbestiform Fibers", 1982-1983 (National Research Council, 1984)
Member, Organizing Committee, 3rd International Workshop on Effects of Mineral Dusts In Vitro, Hochschwarzwald, Germany, September, 1984
Invited Participant, International Conference on Biological Mechanisms of Occupational Lung Disease, Park City, UT, April, 1985
Scientific Program Chairman, 37th Annual Meeting of the Tissue Culture Association, Chicago, IL, 1986
Invited Participant, 14th International Cancer Congress, Panel on Experimental and Human Respiratory Tract Carcinogenesis, Budapest, Hungary, August, 1986
Invited Session Chair, 4th International Conference on Pulmonary Fibrosis, Gothenburg, Sweden, October, 1986
Invited Lecturer, British Association of Lung Research Meeting on "Mineral Fibers," Surrey, U.K., July 13-14, 1987
Invited Session Chair, I.A.R.C. - W.H.O. Symposium, "Mineral Fibers in the Non-Occupation Environment, Lyon, France, September 8-10, 1987
Scientific Program Chair, N.A.T.O.-N.I.H. Advanced Research Workshop on Effects of Mineral Dusts In Vitro, Sherbrooke, Quebec, Canada, 1988
Scientific Program Chair, 10th Scientific Symposium, Vermont Regional Cancer Center, Burlington, VT, December 2, 1988
Invited Session Chair, First International Conference on Health Related Effects of Phyllosilicates, Paris, France, March 16-17, 1989
Invited Session Chair and Speaker, Colloquium Ramazzini International Meeting on "Different Pathogenic Potential of Asbestos Fibers", Ottawa, Canada, March 20-22, 1989
Invited Speaker, International Meeting on "Free Radicals in Health and Disease", Johannesburg, South Africa, July 18-20, 1990
Local Organizing Committee, Sixth International Colloquium on Pulmonary Fibrosis, Stowe, VT, October 14-17, 1990
Scientific Chair, Session on "Evidence for Mechanisms from Cell Culture Studies" N.A.T.O. Meeting on "Mechanisms of Fibre Carcinogenesis", Albuquerque, NM, October 22-25, 1990
Scientific Program Committee, American College of Chest Physicians (ACCP) Fourth International Conference on Environmental Lung Disease, Montreal, Canada, September 24-26, 1991
Scientific Chair, Session on "Epidemiology of Malignant Mesothelioma", International Conference on "Mesothelial Cell and Mesothelioma. Past, Present and Future." Paris, France, September 30 - October 2, 1991
Plenary Lecturer, Second International Meeting on "Free Radicals in Inflammation", Society for Rheumatology, Inflammation, and Free Radical Research Cape Town, South Africa, March 22-26, 1992
Scientific Chair, Session on "In Vitro Assessment of Biopersistence", W.H.O.-I.A.R.C. Meeting, on "Biopersistence of Respirable Synthetic Fibres and Minerals", Lyon France, September 7-9, 1992.
Invited Speaker, 4TH International Life Sciences Institute (ILSI) Symposium "Toxic and Carcinogenic Effects of
Solid Particles in the Respiratory Tract", Hannover, Germany, February 28, 1993
Invited Colloquium Participant, International Centre for Scientific Ecology, Paris, France, May 10, 1993.
Member, Advisory Committee, International Meeting on "Oxygen Radical and Lung Injury" NIOSH-NIH, Morgantown, WV, August 29-September 2, 1993.
Invited Speaker, International Symposium on "Coal Dust Induced Respiratory Disorders", Maastricht, The Netherlands, October 8, 1993
Scientific Organizing Committee, Fifth International Workshop on Effects of Mineral Dusts In Vitro, Creteil, France, October 11-13, 1993
Co-Convener, Symposium on "Health Effects of Mineral Dusts", Mineralogical Society of America, Nantucket, MA, October 22-24, 1993
Invited Speaker, Workshop on "Health Risks Associated with Chrysotile Asbestos", International Commission on Environmental Health, Jersey, Channel Islands, November 14-17, 1993.
Invited Speaker and Session Chair, International Conference on "Crystalline Silica", Baltimore, MD, April 18-20, 1994
Elected Member, Pluto Club (Honorary Society for Investigative Pathologists), September 1994.
Invited Speaker, Postgraduate course on "Cellular Oxidants:Production and Consequences", Queenstown, New Zealand, November 1-3, 1994.
Invited Symposium Speaker and Session Chair, VIIth International Meeting of the Society for Free Radical Research, Sydney, Australia, November 7-11, 1994.
Invited Speaker, 5th International Life Sciences Institute (ILSI) Symposium, "Correlations Between in vitro and in vivo Investigations in Inhalation Toxicology", Hannover, Germany, February 20-24, 1995.
Invited Plenary Lecturer, 5th International Conference on "Environmental and Occupational Disease", American College of Chest Physicians, Orlando, FL, March 2-5, 1995.
Invited Speaker, Third International Mesothelioma Conference, Creteil, France, September 12-15, 1995.
Invited Speaker, British Association for Lung Research, "Fibres, Particles and the Lung: New Perspectives", Edinburgh, Scotland, September 11-12, 1995.
Invited Speaker, Symposium on "Health Effects of Fibrous Minerals Used in Industry Excluding Asbestos", Insulation Wools Research Advisory Board, Sydney Australia, October 30-31, 1995.
Invited Participant, Workshop on "Mechanisms of Fibre Carcinogenesis", Lyon, France, January 9-11, 1996.
Invited Plenary Lecturer, Organizing Committee and Editorial Board, Sixth International Meeting on "Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles", September 6-19, 1996.
Invited Lecturer, Short Course on "Minerals and Health", Institute of Mineralogy and Petrography, University of Fribourg, Switzerland, October 7-11, 1996.
Invited Session Chair on Cell Viability and Death, XIX Annual Meeting, International Society for Heart Research,Vancouver, BC, July 23-27, 1997.
Scientific Organizing Committee and Session Chair, Second International Conference on Oxygen/Nitrogen Radicals and Cellular Injury, Durham, NC, September 7-10, 1997.
Invited Contributor and Session Chair, International Workshop on "Health Effects of Chrysotile Asbestos: Contribution of Science to Risk Management Decisions", Montreal, Canada, September 14-16, 1997.
Invited Speaker, Pleura 1998: Medical Thoracoscopy - Mesothelioma", "Mechanisms of asbestos pathogenesis", Brescia, Italy, October 15-16, 1998.
Outstanding Volunteer Contribution Award, The Oxygen Society, 1998.
Faculty Member and Speaker, "Mechanisms of Asbestos Carcinogenesis", International Conference on Malignant Pleural Mesothelioma", Lignano, Italy, March 18-19, 1999.
Keynote Speaker, "Fibre-induced Carcinogenesis", Fifth International Mesothelioma Interest Group (IMIG), October 5-8, 1999.
Invited Speaker, Symposium on "Asbestos at the End of the Century: Basic Science for Substitutes, Removal and Therapies", Torino, Italy, October 11, 1999.
Scientific Organizing Committee and Invited Speaker, "Cell Signalling by Fibres", 7th International Meeting on Particle Toxicology, Maastricht, The Netherlands, October 14-17, 1999.
Scientific Organizing Committee, International Conference on Basic and Clinical Aspects of Cell Cycle Control, Siena, Italy, May 29-30, 2000.
Scientific Organizing Committee and Invited Speaker, Third International Symposium on Reactive Oxygen/Nitrogen Species in Cell Injury and Disease, NIOSH, Morgantown, WV, September 16-19,2001.

Current Appointments:

Editorial Boards: In Vitro Cell. Dev. Biol., 1987-; Toxicol. Appl. Pharmacol., 1993-; Free Rad. Biol. Med., 1993-; Lab. Invest., 1996-; Am. J. Physiol. Lung Cell Molec. Physiol. 1996-; Am. J. Respir. Cell Mol. Biol., 1998-
American Association of Cancer Research, State Legislature Committee
Scientific Advisory Board, Owens-Corning, 1999-
Scientific Advisory Board, CIIT, Centers for Health Research, 1995-
External Advisory Committee, NIEHS Center at Oregon State University, 1996-
Board of Scientific Counselors (Subcommittee on Basic Research), National Cancer Institute, 2000-2005

Past Appointments:
Site visit participant and reviewer of grants for National Science Foundation; Environmental Protection Agency; National Cancer Insti-tute; National Heart, Blood and Lung Institute; Member of Special Review Group on Chemoprevention Projects; National Cancer Institute; Study Section on Small Business Innovative Research (SBIR) Grants, NCI ; National Science and Engineering Research Council of Canada; Veterans Administration research awards; Medical Research Council of Canada, American Cancer Society; Western Provinces Lung Association Grant Review Committee; Nickel Producers Environmental Research Association; Center for Indoor Air Research Contributor, Surgeon General's Report, "Smoking Related Cancer and Chronic Lung Disease in the Workplace", 1985
Consultant, E.P.A. Scientific Advisory Board for Review of Airborne Asbestos Health Update, 1985
External Advisory Committee, Stony Brook-Brookhaven Program project on "Particle Deposition and Clearance by the Lung", 1985
Panel, Environmental Asbestos Risk Assessment, Third International Conference on Environmental Lung Disease, Montreal, Canada, October, 1986
External Advisory Committee, University of California at Davis, Program "Pulmonary Effects of Environmental Oxidants", December 1987-1990
Scientific Advisory Committee, Alternative Approaches to Animal Testing, Proctor and Gamble, Cincinnati, OH, September, 1988
Scientific Advisory Committee, Owens-Corning Fiberglas, Toledo, OH, 1988-1989
External Advisory Committee, Asbestos Research, Health Effects Research Institute, Cambridge, MA, October 31 - November 1, 1988
Literature Review Panel on Asbestos, Health Effects Research Institute, 1990-1992
Chemical Pathology Study Section, NIH, Ad Hoc, 1992, 1995
Member, Human Exposure and Health Effects Grant Review Panel, US Environmental Protection Agency, 1989-1993.
Member, NIOSH Board of Scientific Counselors, Fiber Subcommittee, 1989-1993.
Pulmonary Diseases Advisory Committee, NHLBI, 1990-1994 (Chair, 1994).
Scientific Advisory Committee for Research Grants (Personnel for Research), American Cancer Society, 1991-1994.
Representative of the American Association of Pathology to the FASEB Life Sciences Research Advisory Committee, 1991-1994.
Invited guest of the Lung Division to NHLBI Council Meetings, September 1993 and 1994.
American Thoracic Society, Planning Committee, 1994-1997
American Association for Cancer Research, Program Committee (Lung Cancer), 1994
Co-Chair (with Dr. Gary Hunninghake), NHLBI, Coordination of Special Emphasis Research Panels for the Lung Division, 1994
Member, US Environmental Protection Agency, Science Advisory Board, Environmental Health Committee, 1986-1996
Assembly on Environmental and Occupational Health, Program Committee, American Thoracic Society (ATS), 1992-1996
Ad Hoc Reviewer of the Laboratory of Human Carcinogenesis, Division of Basic Sciences, National Cancer Institute, September, 1996.
Contributor and Panel Member, Relevance of the Rat Lung Response to Particle Overload for Human Risk
Assessment, ILSI Risk Science Institute, Washington, DC, 1998.
Council member, The Oxygen Society, 1995-1999; Chair, Annual Mtg., Washington, DC, Nov. 1998
Lung Biology and Pathology Study Section, NIH July 1995-1999
American Society Investigative Pathology, FASEB Program Committee, 1997-2000
NIH Ad Hoc Reviewer: Special Emphasis Panels (Clinical Sciences) on a regular basis.

Participant/Speaker in NIH Workshops:
"Pleural Cell Biology in Health and Disease", NHLBI, October 1-2, 1990.
"Neuroendocrine Cells in Pulmonary Biology", NHLBI, September 5-6, 1991.
"Research Needs and Opportunities Related to the Respiratory Health of Women", NHLBI, January 30-31, 1992.
Co-chair, "Environmental Lung Disease: Relationship Between Acute Inflammatory Responses to Air Pollutants and Chronic Lung Disease", NHLBI/NIEHS, May 29-31, 1991.
Co-chair, "In Vivo Cell Biology", NHLBI, June 7-8, 1993.
"Pulmonary Complications of Breast Cancer Therapy", NHLBI, September 20, 1993.
"New Approaches to Pulmonary Fibrosis", NHLBI, August 30-31, 1994.
Chair, "Genetics and Gene Therapy for the Study of Pulmonary Diseases", NHLBI, September 23-24, 1994.
Chair, "Strategies for Interventions in Aging and Age-Related Diseases", NIA, July 14-16, 1999.
Training Evaluation Working Group, NIEHS, September 14-15, 1999.
Planning Committee and Chair of Working Group, Signal Transduction Workshop, NIEHS, April 11-12, 2001.
Working Group on Pulmonary Fibrosis, NHLBI, June 26-27, 2001.

Societies, Panels, Workshops and Reviews:
American Society of Cell Biology
American Association for the Advancement of Science
Sigma Xi Scientific Honor Society
Oxygen Society
Tissue Culture Association
American Association for Cancer Research
American Thoracic Society
American Society of Investigative Pathology
Reviewer for: Journal of Cellular Physiology, Environmental Research, Cell Biology & Toxicology, In Vitro Toxicology, Cancer Research, Experimental Cell Research, Experimental Lung Research, Scanning Electron Micros-copy, American Journal of Pathology, Science, American Industrial Hygiene Association Journal, European Journal of Cancer & Clinical Oncology, Journal of Toxicology and Applied Pharmacology, Environmental Mutagene-sis, Carcinogenesis, American Review of Respir-atory Diseases, Journal of the American College of Toxicology, Journal of the National Cancer Institute, Nature, Journal of Leuko-cyte Biology, New England Journal of Medicine, Cell & Tissue Kinetics, Clinical Pathology and Pharmacology, American Journal of Respiratory Cell and Molecular Biology, Risk Analysis, Clays and Clay Minerals, Chest, Chemical Research in Toxicology, Atherosclerosis, Journal of Clinical and Laboratory Medicine, New Journal of Chemistry, Drug and Chemical Toxicology (past section Head of In Vitro Toxicology), Archives of Biochemistry & Biophysics.

Refereed Manuscripts, Invited Book Chapters, Editorials, and Monograph Chapters:

1. Sivak A, Mossman BT, Van Duuren BL: Activation of cell membrane enzymes in the stimulation of cell division. Biochem Biophys Res Comm 46:605, 1972.
2. Mossman BT, Gray MJ, Silberman L, Lipson RL: Identification of neo-plastic vs. normal cells in human cervical cell culture. J Obstet Gynecol 43:635, 1974.
3. Mossman BT, Craighead JE: Topical application of polycyclic hydrocarbons to differentiated respiratory epithelium in long-term organ cultures. In: Experimental Lung Cancer (E. Karbe and J.F. Park, eds), Springer-Verlag, Berlin, p. 514, 1974.
4. Mossman BT, Craighead JE: Long-term maintenance of differ-entiated respiratory epithelium in organ culture. I. Medium composition. Proc Soc Exp Biol Med 149:227, 1975.
5. Mossman BT, Ley BW, Craighead JE: Squamous metaplasia of the tracheal epithelium in organ culture. I. Effects of hydro-cortisone and ?-retinyl acetate. Exp Mol Path 24:405, 1976.
6. Mossman BT, Kessler JB, Ley BW, Craighead JE: Inter-action of crocidolite asbestos with hamster respiratory mucosa in organ culture. Lab Invest 36:131, 1977.
7. Mossman BT, Craighead JE: Organ culture of the hamster bladder epithe-lium. Tissue Culture Assoc Manual 3:623, 1977.
8. Mossman BT: Autoradiography for determination of DNA synthesis in hamster bladder epithelium. Tissue Culture Assoc Manual 3:663, 1977.
9. Mossman BT, Heintz N, MacPherson BV, Craighead JE: Squamous metaplasia of the tracheal epithelium in organ culture. II. Nutritional influences. Proc Soc Exp Biol Med 157:500, 1978.
10. Mossman BT, Craighead JE: Induction of neoplasms in hamster tracheal grafts with 3-methylcholanthrene-coated Lycra fibers. Cancer Res 38:3717, 1978.
11. Mossman BT, Adler KB, Craighead JE: Interaction of carbon par-ticles with tracheal epithelium in organ culture. Environ Res 16:110, 1978.
12. Craighead JE, Mossman BT: Carcinoma induction by 3-methyl-cholanthrene in hamster tracheal tissue implanted in syngeneic animals. Prog Exp Tumor Res 24:48, 1979.
13. Mossman BT, Craighead JE: Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium. Prog Exp Tumor Res 24:37, 1979.
14. Mossman BT, Craighead JE, MacPherson BV: Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhi-bition by retinyl methyl ether. Science 207:311-313, 1980.
15. Craighead JE, Mossman BT, Bradley BJ: Comparative studies on the cytotoxicity of amphibole and serpentine asbestos. Environ Health Per-spect 34:37, 1980.
16. Last JA, Kaizu T, Mossman BT: Glycoprotein synthesis by an established cell line from hamster tracheal epithelium. Exp Lung Res 1:89, 1980.
17. Mossman BT, Ezerman EB, Adler KB, Craighead JE: Isolation and spontaneous transformation of cloned lines of hamster tracheal epithelial cells. Cancer Res 40:4403, 1980.
18 Mossman BT: Use of tracheal organ cultures and grafts to explore the interactions of environmental particulates with respiratory epithelial cells. In Topics in Environmental Pathology, Universities Associated for Research and Education in Pathology, Inc., p. 89, 1980.
19. Mossman BT, Adler KB, Craighead JE: Cytotoxic and proliferative changes in trachael organ cultures after exposure to mineral dusts. In: The In Vitro Effects of Mineral Dusts (R.C Brown et al, eds.) Academic Press, London, p. 241, 1980.
20. Mossman BT, Craighead JE: Mechanisms of asbestos carcino-genesis. Environ Res 25:269, 1981.
21. Eastman A, Mossman BT, Bresnick E: Formation and removal of benzo(a)pyrene adducts of DNA in hamster tracheal epithelial cells. Cancer Res 41:2605, 1981.
22. Woodworth CD, Mossman BT, Craighead JE: Comparative effects of fibrous and nonfibrous minerals on cells and liposomes. Environ Res 27:190-205, 1982.
23. Mossman BT, Adler KB, Jean L, Craighead JE: Mechanisms of hypersecretion in rodent tracheal explants after exposure to chrysotile asbestos. Studies using lectins. Chest 81:235, 1982.
24. Landesman JM, Mossman BT: Induction of ornithine decar-boxylase in hamster tracheal epithelial cells exposed to asbestos and 12-O-tetra-decanoylphorbol-13 acetate. Cancer Res 42:3669, 1982.
25. Eastman A, Mossman BT, Bresnick E: Modulation of the interaction of benzo(a)pyrene with a hamster tracheal epithelial cell line. Carcinogen-esis 3:1283, 1982.
26. Craighead JE, Mossman BT: The pathogenesis of asbestos--associated diseases. N Engl J Med 306:1446, 1982.
27. Mossman BT, Craighead JE: Comparative cocarcinogenic effects of kaolin, hematite, carbon and crocidolite asbestos in implanted tracheal organ cultures. In Inhaled Particles, Pergamon Press, London, Vol. V, p. 572, 1982.
28. Mossman BT: Mechanisms of asbestos-induced carcinogenesis in hamster trachea. Proc. 12th Conference on Environmental Toxicology, Report #AFAMRL-TR-81-149, Aerospace Medical Research Laboratory, p. 1, 1982.
29. Mossman BT and Craighead JE: Mechanisms of asbestos and nonasbestiform particles and fibers in bronchogenic carcinoma. Health Issues Related to Metal and Nonmetallic Mining (WL Wagner, WN Rom and JA Merchants, eds), Butterworth Publishers, Boston, p. 123, 1983.
30. Mossman BT, Jean L, Landesman JM: Studies using lectins to determine mineral interaction with cellular membranes. Environ Health Perspect 51:23, 1983.
31. Woodworth C, Mossman BT, Craighead JE: Interaction of asbestos with metaplastic squamous epithelium developing in organ cultures of hamster trachea. Environ Health Perspect 51:27, 1983.
32. Mossman BT, Eastman A, Landesman JM, Bresnick E: Effects of crocidolite and chrysotile asbestos on cellular uptake and metabolism of benzo(a)pyrine in hamster tracheal epithelial cells. Environ Health Perspect 51:331, 1983.
33. Mossman BT, Landesman JM: Importance of oxygen free radicals in asbestos-induced injury to airway epithelial cells. Chest 83S:50S, 1983.
34. Mossman BT, Light W, Wei E: Asbestos: Mechanisms of toxicity and carcinogenicity in the respiratory tract. Ann Rev Pharmacol Toxicol 23:595, 1983.
35. Wilson GL, Mossman BT, Craighead JE: Use of pancreatic beta cells in culture to identify diabetogenic N-nitroso compounds. In Vitro 19:25, 1983.
36. Eastman A, Mossman BT, Bresnick E: Influence of asbestos on uptake and alkylation to DNA of benzo(a)pyrene in hamster tracheal epithelial cells. Cancer Res 43:1251, 1983.
37. Woodworth CD, Mossman BT, Craighead JE: Squamous metaplasia of the respiratory tract - Possible pathogenic role in asbestos-associated bronchogenic carcinoma. Lab Invest 48:578, 1983.
38. Woodworth CD, Mossman BT, Craighead JE: Induction of squamous metaplasia in organ cultures of hamster trachea by natur-ally occurring and synthetic fibers. Cancer Res 43:4906-4913, 1983.
39. Mossman BT: In vitro approaches for determining the mechanisms of toxicity and carcinogenicity of asbestos in the gastrointestinal and respiratory tracts. Environ Health Perspect 53:428, 1983.
40. Craighead JE, Adler KB, Butler GB, Emerson RJ, Mossman BT, Woodworth CD: Health effects of Mount St. Helens volcanic dust. Lab Invest 48:5, 1983.
41. Mossman BT, Eastman A, Bresnick E: Asbestos and benzo(a)pyrene act synergistically to induce squamous metaplasia and incorporation of [3H]thymidine in hamster tracheal epithelium. Carcinogenesis 5:1401-1404, 1984.
42. Adler KB, Mossman BT, Butler GB, Jean LM, Craighead JE: Inter-action of Mount St. Helens volcanic ash with cells of the respiratory epithelium. Environ Res 35:346, 1984.
43. Wilson GL, Patton NJ, McCord JM, Mullins DW, Mossman BT: Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells. Diabetologia 27:587, 1984.
44. Bernacki RJ, Wilson GL, Mossman BT, Angelino N, Kanter PM, Korytnyk, W: The therapeutic and diabetogenic potential of two newly synthesized nitrosoureido-sugars. Cancer Res 45:695, 1985.
45. Mossman BT and Marsh JP: Mechanisms of toxic injury by asbestos fibers: Role of oxygen free radicals. In: In Vitro Effects of Mineral Dusts, Third International Workshop, (EE Beck and J Bignon, eds.), NATO ASI Series, Springer-Verlag, Berlin, p. 66, 1985.
46. Fisher GL, McNeill KL, Mossman BT, Marsh J, McFarland AR and Hart RW: Investigations into the mechanisms of asbestos toxicity. In: In Vitro Effects of Mineral Dusts, Third International Workshop, (EE Beck and J Bignon, eds.), NATO ASI Series, Springer-Verlag, Berlin, p. 31, 1985.
47. Marsh JP, Jean L and Mossman BT: Asbestos and fibrous glass induce biosynthesis of polyamines in tracheobronchial epithelial cells in vitro. In: In Vitro Effects of Mineral Dusts, Third International Workshop, (EE Beck and J. Bignon, eds), NATO ASI Series, Springer-Verlag, Berlin, p. 305, 1985.
48. Mossman BT, Cameron GS and Yotti LP: Cocarcinogenic and tumor promoting properties of asbestos and other minerals in tracheobronchial epithelium. In Cancer: A Comprehensive Survey: Cancer of the Respiratory Tract, Predis-posing Factors. (MJ Mass et al, eds), Raven Press, NY, p. 217-238, 1985.
49. Mossman BT, Eastman A, Landesman JM, Bresnick E and Craighead JE: Interactions of asbestos and polycyclic aromatic hydrocarbons (PAH) in carcinogenesis of the respiratory tract. In: Occupational Lung Disease. JBL Gee, WK Morgan and SM Brooks, eds, Raven Press, NY, pp. 171-173, 1985.
50. Mossman BT and Eastman A: Carcinogenesis and lung cancer. In: Lung Carcinomas (EM McDowell, vol ed), In Series: Current Problems in Tumor Pathology (J Azzopardi and N Wright, series eds), Churchill Livingstone. p. 128, 1986.
51. Mossman BT: Mechanisms of chemical and physical carcinogenesis in cultured hamster and human tracheobronchial epithelium. In: In Vitro Models of Respiratory Epithelium, (LJ Schiff, ed), CRC Press, Inc., Boca Raton, p. 161, 1986.
52. Mossman BT, Wilson GL, Craighead JE: A diabetogenic analogue of streptozocin with dissimilar mechanisms of action on pancre-atic beta cells. Diabetes 34:602, 1986.
53. Mossman BT, Marsh JP, Shatos MA: Alteration of super-oxide dismutase (SOD) activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants. Lab Invest 54:204, 1986.
54. Mossman BT, Gilbert R, Shatos M, Doherty J, Marsh JP, Cutroneo K: Cellular and molecular mechanisms of asbestosis. Chest 89:160, 1986.
55. Mossman BT, Ireland CM, Filipak M, LeDoux S, Wilson GL: Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr). Diabetologia 29:186, 1986.
56. Mossman BT, Marsh JP, Hardwick D, Gilbert R, Hill S, Sesko A, Shatos M, Doherty J, Weller A, and Bergeron M: Approaches to prevention of asbestos-induced lung disease using polyethylene glycol (PEG)-conjugated catalase. J Free Rad Biol Med 2:335-338, 1986.
57. Finch GL, Hayes TL, Mossman BT, Chang MJW and Fisher GL: SEM of tracheal respiratory epithelium exposed in vitro to Ni3S2. In: Microbeam Analysis - 1986 (AD Romig, Jr. and WF Chambers, eds) San Francisco Press, San Francisco, p. 591, 1986.
58. Hansen K, Mossman BT: Generation of superoxide (O-.2) from alveolar macrophages exposed to asbestiform and nonfibrous particles. Cancer Res 47:1681-1686, 1987.
59. Shatos MA, Doherty JM, Marsh JP, Mossman BT: Prevention of asbestos-induced cell death in rat lung fibroblasts and alveolar macrophages by scavengers of active oxygen species. Environ Res 44:103-116, 1987.
60. Mossman BT and Craighead JE: Mechanisms of carcinogenesis. In: Asbestos-Related Neoplasms (K Antman and J Aisner, eds), Grune and Stratton, New York, p. 137, 1987.
61. Craighead JE and Mossman BT: Pathogenesis of mesothelioma: In: Asbestos-Related Neoplasms (K Antman and J Aisner, eds), Grune and Stratton, New York, p. 151, 1987.
62. Mossman BT: How safe are asbestos substitutes? Studio Potter 15:36, 1987.
63. Mossman BT, Marsh JP, Shatos MA, Doherty J and Hill S: Implication of active oxygen species as second messengers of asbestos toxicity. Drug & Chemical Toxicology 10:157, 1987.
64. Fisher GL, Mossman BT, McFarland AR and Hart RW: A possible mechanism of chrysotile asbestos toxicity. Drug & Chemical Toxicology, 10:(1&2), 109-131, 1987.
65. Marsh JP, Mossman BT: Mechanisms of induction of ornithine decarboxylase activity in tracheal epithelial cells by asbestiform minerals. Cancer Res 48:709-714, 1988.
66. Mossman BT: Hamster tracheal organ and cell culture - State-of-the-art and application to studies of respiratory carcinogenesis by polycyclic aromatic hydrocarbons (PAH) and asbestos. In: In Vitro Models for Cancer Research, Vol. VI, (MM Webber and LI Sekely, eds), CRC Press, Inc., Boca Raton, p. 51, 1988.
67. Mossman BT: Carcinogenic potential of asbestos and nonasbestos fibers. Environmental Carcinogenesis Reviews, (J Environ Sci Health) C6(2) pp. 151-195, 1988.
68. Kehrer J, Mossman BT, Sevanian A, Trush M, and Smith M: Free radical mechanisms in chemical pathogenesis. Toxic Appl Physiol 95:349-362, 1988.
69. Lown JW, Mossman BT, Doroshow JH and Kensler TK: Oxidants in xenobiotic induced tissue damage. In: Proceedings of Upjohn-UCLA Symposium on Oxy-Radicals in Molecular Biology and Pathology. (P Cerutti, I Fridovich and JM McCord, eds.) Alan R. Liss, Inc., New York, p. 387, 1988.
70. Abraham JL, Smith CM and Mossman BT: Chrysotile and crocidolite asbestos pulmonary fiber concentrations and dimensions after inhalation and clearance in Fischer 344 rats. In: Inhaled Particles, VI, Ann Occup Hyg 32:203, 1988.
71. Sesko A, Mossman BT: Sensitivity of hamster tracheal epithelial cells to asbestiform minerals is modulated by serum and by transforming growth factor, beta 1. Cancer Res 49:2743-2749, 1989.
72. Mossman BT, Gee JBL: Medical Progress. Asbestos-related diseases. N Engl J Med 320:1721-1730, 1989.
73. Mossman BT, Hansen K, Marsh J, Brew ME, Hills S, Bergeron M, and Petruska J: Mechanisms of fiber-induced superoxide (0-.2) release from alveolar macrophages (AM) and induction of superoxide dismutase (SOD) in the lungs of rats inhaling crocidolite. In: Mineral Fibres in the Non Occupational Environment, (J Bignon, J Peto & R Saracci, eds) IARC Publication No. 90, Lyon, France, p. 81, 1989.
74. Cameron G, Woodworth CD, Edmundson S and Mossman BT: Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells. Monograph on Regulation of Differentiation in Eucaryotic Cells. Environ. Health Perspect 80:101, 1989.
75. Mossman BT: Evidence supporting a role for active oxygen species in asbestos-induced toxicity and disease. Symposium on Scientific Advances in Environmental Medicine. Environ Health Perspect 81:91-94, 1989.
76. Perderiset M, Marsh JP, and Mossman BT: Effects of asbestos on specific binding of phorbol ester tumor promoter and protein kinase C activity in hamster tracheal epithelial (HTE cells). In: Mossman BT and Begin R (eds) Effects of Mineral Dusts on Cells, NATO ASI Series on Cell Biology, Springer-Verlag, Berlin, p. 433, 1989.
77. Mossman BT and Begin R (eds) Effects of Mineral Dusts on Cells, NATO ASI Series on Cell Biology, Springer-Verlag, Berlin, 1989.
78. Mossman BT and Gilbert R: Factors influencing individual responses to asbestos-associated diseases: effect of smoking on the development of lung cancer. In: Proceedings of the Symposium on the Health Aspects of Asbestos in Buildings, Harvard University, Boston, p. 141, 1989.
79. Mossman BT, Bignon J, Corn M, Seaton A, Gee JBL: Asbestos: Scientific developments and implications for public policy. Science 247:294-301, 1990.
80. Edmondson SW, Wu R, Mossman BT: Regulation of differentiation and keratin protein expression by vitamin A in primary cultures of hamster tracheal epithelial cells. J Cell Physiol 142:21-30, 1990.
81. Petruska JM, Marsh J, Bergeron M, Mossman BT: Brief inhalation of asbestos compromises superoxide production in cells from bronchoalveolar lavage. Am J Respir Cell Mol Biol 2:129-136, 1990.
82. Mossman BT, Marsh JP, Sesko A, Hill S, Shatos MA, Doherty J, Petruska J, Adler KB, Hemenway D, Mickey R, Vacek P, Kagan E: Inhibition of lung injury, inflammation and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am Rev Respir Dis 141:1266-1271, 1990.
83. Petruska JM, Wong SHY, Sunderman FW, Jr, Mossman BT: Detection of lipid peroxidation in lung and in bronchoalveolar lavage cells and fluid. Free Rad Biol Med 9:51-58, 1990.
84. Mossman BT, Sesko AM: In vitro assays to predict the pathogenicity of mineral fibers. Toxicology 60:53-61, 1990.
85. Janssen Y, Marsh JP, Absher M, Borm PJA, Mossman BT: Increases in antioxidant enzymes during asbestos inhalation in rats. Free Rad Res Comm 11:53, 1990.
86. Sesko A, Cabot M, Mossman BT: Hydrolysis of phosphoinositides precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells. Proc Natl Acad Sci, USA 87:7385-7389, 1990.
87. Mossman BT, Janssen YMW, Marsh JP, Manohar M, Garrone M, Shull S: Antioxidant defense mechanisms in asbestos-induced lung diseases. J Aerosol Med 3:75, 1990.
88. Mossman BT, Marsh JP, Dantona R, Bergeron M and Senior A: Involvement of active oxygen species in injury, repair and proliferation of tracheobronchial epithelial cells after exposure to asbestos fibers. In: Biology, Toxicology and Carcinogenesis of Respiratory Epithelium (D Thomassen and P Nettesheim, eds) Hemisphere Publishing Corp., Washington, DC, pp. 145-154, 1990.
89. Brown RC, Hoskins JA, Miller K and Mossman BT: Pathogenetic mechanisms of asbestos and other mineral fibers. Mol Aspects Med 11:325, 1990.
90. Mossman BT: In Vitro Studies on the biologic effects of fibers - correlation with in vivo bioassays, Environ Health Perspect 88:319-322, 1990.
91. Mossman BT: How great is risk from asbestos? Forum Appl Res & Public Policy, Vol 5, p. 76, 1990.
92. Gee JBL and Mossman BT: Asbestos warrants care and management, but society must resist urge to panic. Occup Health and Safety 59:25, 1990.
93. Marsh JP, Mossman BT: Role of asbestos and active oxygen species in activation and expression of ornithine decarboxylase in hamster tracheal epithelial cells. Cancer Res 51:167-173, 1991.
94. Edmondson SE, Mossman BT: Alterations in keratin expression in hamster tracheal epithelial cells exposed to benzo[a]pyrene. Carcinogenesis 12:679-684, 1991.
95. Perderiset M, Marsh JP, Mossman BT: Activation of protein kinase C by asbestos in hamster tracheal epithelial cells. Carcinogenesis 12:1499-1502, 1991.
96. Petruska JM, Leslie KO, Mossman BT: Enhanced lipid peroxidation in bronchoalveolar lavage of rats after inhalation of crocidolite asbestos. Free Rad Biol Med 11:425, 1991.
97. Shull S, Heintz NH, Periasamy M, Manohar M, Janssen YMW, Marsh JP, Mossman BT: Differential regulation of antioxidant enzymes in response to oxidants. J Biol Chem 266:24398, 1991.
98. Mossman BT: The great debate. 1991 Asbestos Management Sourcebook, pp. 16-17.
99. Petruska JM, Mossman BT, Brown RC, and Hoskins JA: Mechanisms of action of mineral fibers as studied by in vitro methods, In: Mineral Dusts and Disease (K Miller and FDK Liddell, eds.), Chpt. 22, CRC Press, Inc., Boca Raton pp. 299-315, 1991.
100. Mossman BT and Marsh JP: Role of active oxygen species in asbestos-induced cytotoxicity, cell proliferation and carcinogenesis. In: Cellular and Molecular Aspects of Fiber Carcinogenesis (B Brinkley, J Lechner and C Harris, eds) Series on Current Comm in Mol Biol, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY pp. 159-168, 1991.
101. Janssen YWM, Marsh JP, Borm PJA, Surinrut P, Haldeman K and Mossman BT: Asbestos mediated gene expression in rat lung. In: Mechanisms in Fibre Carcinogenesis (RC Brown et al., eds) Plenum Press, pp. 359-365, 1991.
102. Mossman BT: Fiber carcinogenesis and environmental risks, In: Asbestos-related Cancer, Chpt. 16, (M Sluyser, ed), The Netherlands Cancer Inst., Amsterdam, Ellis Horwood, New York. pp. 241-255, 1991.
103. Mossman BT, Janssen, YM, Marsh JP, Sesko A, Shatos MA, Doherty J, Adler KB, Hemenway D, Mickey R, Vacek P, Petruska J, and Kagan E: Development and characterization of a rapid-onset rodent inhalation model of asbestosis for disease prevention. Toxicol Pathol 19:412-418, 1991.
104. Janssen YMW, Marsh JP, Absher MP, Hemenway D, Vacek PM, Leslie KO, Borm PJA, Mossman BT: Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica. J Biol Chem 267:10625-10630, 1992.
105. Holley JA, Janssen YMW, Mossman BT, Taatjes DJ: Increased manganese superoxide dismutase protein in Type II epithelial cells of rat lungs after inhalation of crocidolite asbestos or cristobalite silica. Am J Pathol 141:475-485, 1992.
106. Crapo JD, Miller FJ, Mossman BT, Pryor WA and Kiley JP: NHLB Workshop Summary - Environmental Lung Disease: Relationship between acute inflammatory responses to air pollutants and chronic lung disease. Am Rev Respir Dis 145:1506-1512, 1992.
107. Antony VB, Sahn SA, Mossman BT, Gail DB, and Kalica A: NHLBI Workshop Summary - Pleural Cell Biology in Health and Disease. Am Rev Respir Dis 145:1236-1239, 1992.
108. Mossman BT: Asbestos: an update. In: Cancer Prevention (VT Devita, Jr, S Hellman and SA Rosenberg, eds., JB Lippincott Co., Philadelphia, PA., p. 1-11, October 1992.
109. Shull S, Manohar M, Marsh JP, Janssen YMW and Mossman BT: Role of iron and reactive oxygen species in asbestos-induced lung injury, In: Free Radical Mechanisms of Tissue Injury, (MT Moslen and CV Smith, eds) CRC Press, Boca Raton, pp153-162, 1992.
110. Janssen YMW, Borm PJA, Van Houten B, Mossman BT: Biology of Disease: Cell and tissue responses to oxidative damage. Lab Invest 69:261-274, 1993.
111. Heintz NH, Janssen YMW, Mossman BT: Persistent induction of c-fos and c-jun expression by asbestos. Proc Natl Acad Sci USA 90:3299-3303, 1993.
112. Mossman BT and Gee JBL: Pulmonary reactions and mechanisms of toxicity of inhaled fibers, In: Toxicology of the Lung (DE Gardner, JD Crapo and RO McClellan, eds), Raven Press, NY, 2nd Ed, pp. 371-387, 1993.
113. Mossman BT: Mechanisms of asbestos carcinogenesis and toxicity: the amphibole hypothesis revisited. Br J Ind Med 50:673-676, 1993.
114. Marsh JP, Janssen YMW and Mossman BT: Ornithine decarboxylase and tumour proliferation: Role for oxidants. In: DNA and Free Radicals (B Halliwell and OI Aruoma, eds), Ellis Horwood, Ltd., p. 230, 1993.
115. Mossman BT: Point/counterpoint on carcinogenicity of asbestos: occupational vs. environmental risks. In: Biology: the Unity and Diversity of Life (DD Chiras, ed), West Educational Publishing Co., St. Paul, MN, pp. 338, 1993.
116. Quinlan T, Spivack S, Mossman BT: Regulation of antioxidant enzymes in lung after oxidant injury. Environ Health Persp 102:79-87, 1994.
117. Janssen YMW, Marsh JP, Driscoll KE, Borm PJA, Oberdörster G, Mossman BT: Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. Free Radic Biol Med 16:315-322, 1994.
118. Janssen YMW, Marsh JP, Absher MP, Gabrielson E, Borm PJA, Driscoll KE, and Mossman BT: Oxidant stress responses in human pleural mesothelial cells. Am J Respir Crit Care Med 149:795-802, 1994.
119. Quinlan TR, Marsh JP, Janssen YMW, Leslie KO, Hemenway D, Vacek P, Mossman BT: Dose responsive increases in pulmonary fibrosis after inhalation of asbestos. Am J Respir Crit Care Med 150:200-206, 1994.
120. Marsh JP, Mossman BT, Driscoll KE, Schins RF, Borm PJA: Effects of Aramid, a high strength synthetic fiber, on respiratory cells in vitro. Drug Chem Toxicol 17:75-92, 1994.
121. Janssen YMW, Heintz NH, Marsh JP, Borm PJA, Mossman BT: Induction of c-fos and c-jun protooncogenes in target cells of the lung and pleura by carcinogenic fibers. Am J Respir Cell Mol Biol 11:522-530, 1994.
122. Mossman BT: Carcinogenesis and related cell and tissue responses to asbestos: a review. Ann Occup Hyg 38:617-624, 1994.
123. Mossman BT: Asbestos: facts and fiction [letter]. Environ Health Perspect 102:424-426, 1994.
124. Janssen YMW, Borm PJA, Marsh JP and Mossman BT: Role of active oxygen species in lung toxicity induced by mineral fibers and particulates. In: Environmental Oxidants (JO Nriagu and MS Simmons, eds), Vol. 28, Advances in Environmental Science and Technology, John Wiley & Sons, NY, p. 445-458, 1994.
125. Driscoll KE, Strzelecki J, Hassenbein D, Janssen YMW, Marsh J, Oberdorster G and Mossman BT: Tumour necrosis factor (TNF): Evidence for the role of TNF in increased expression of manganese superoxide dismutase after inhalation of mineral dusts. In: Inhaled Particles VI, Ann Occup Hyg, Pergamon Press, Vol. 38 (Suppl 1), pp. 375-382, 1994.
126. Janssen YMW, Marsh JP, Quinlan T, Timblin C, BeruBe K, Jimenez A, Fung H, Taishi P, Zanella C, Heintz N, and Mossman BT: Activation of early cellular responses by asbestos: Induction of c-fos and c-jun protooncogene expression in rat pleural mesothelial cells. In: Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres, NATO-ASI Series, Springer-Verlag, Berlin, pp. 205-213, 1994.
127. Mossman BT, Marsh JP, Janssen YMW, Heintz NH: Mechanisms of asbestos-mediated DNA replication and cell proliferation. In: Dungworth DL, Mauderly J, Oberdorster G, eds., Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract. ILSI Press, Washington, DC, pp. 191-198, 1994.
128. Crapo JD, Malik AB, Mossman BT and Gail DB: NHLBI Workshop Summary: In Vivo Cell Biology. Am J Respir Crit Care Med 150:282-286, 1994.
129. Mossman BT: Carcinogenesis and related cell and tissue responses to asbestos: a review. Ann Occup Hyg 38:617-614, 1994.
130. Quinlan TR, Marsh JP, Janssen YMW, Borm PA, Mossman BT: Oxygen radicals and asbestos-mediated disease. Environ Health Perspect 102(Suppl. 10):107-110, 1994.
131. Driscoll KE, Maurer JK, Hassenbein D, Carter J, Janssen YMW, Mossman BT, Osier M, and Oberdorster G: Contribution of macrophage-derived cytokines and cytokine networks to mineral dust-induced lung inflammation. In: Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract. ISLI Press, Washington, DC, pp. 177-190, 1994.
132. Janssen YMW, Barchowsky A, Treadwell M, Driscoll KE and Mossman BT: Asbestos induces nuclear factor ?B (NF-?B) DNA-binding activity and NF-?B-dependent gene expression in tracheal epithelial cells. Proc. Natl Acad Sci USA 92:8458-8462, 1995.
133. Driscoll KE, Hassenbein DG, Carter JM, Kunkel SL, Quinlan TR and Mossman BT: TNF? and increased chemokine expression in rat lung after particle exposure. Toxicol Lett 82/83:483-489, 1995.
134. Quinlan TR, BeruBe KA, Marsh JP, Janssen YMW, Taishi P, Leslie KO, Hemenway D, O'Shaughnessy PT, Vacek P and Mossman BT: Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos. Am J Pathol 147:728-739, 1995.
135. Timblin CR, Janssen YWM, Mossman BT: Transcriptional activation of the proto-oncogene c-jun, by asbestos and H2O2 is directly related to increased proliferation and transformation of tracheal epithelial cells. Cancer Res 55:2723-2726, 1995.
136. Janssen YM, Heintz NH and Mossman BT: Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells. Cancer Res 55:2085-2089, 1995.
137. Mossman BT, Quinlan T and Janssen YMW: Active oxygen species. In: Pathology of Human Environmental and Occupational Disease (JE Craighead, ed), Mosby Year-Book, Inc., St. Louis, pp. 347-357, 1995.
138. Gee JBL and Mossman BT: Basic mechanisms in occupational lung disease including lung cancer and mesothelioma In: Occupational Lung Diseases (WKC Morgan and A Seaton, eds), 3rd Ed, WB Saunders, Orlando, pp. 191-221, 1995.
139. Mossman BT, Jimenez LA, BeruBe K, Quinlan T and Janssen YMW: Possible mechanisms of crystalline silica-induced lung disease. Appl Occup Environ Hyg 10:1115-1117, 1995.
140. Mossman BT and Gee JBL: Basic mechanisms in occupational lung diseases including lung cancer and mesothelioma. In: Morgan K and Santon A, eds., Occupational Lung Diseases, 3rd edi., W. B. Saunders, Philadelphia, pp. 191-221, 1995.
141. Mossman BT, Mason R, McDonald JA and Gail DB: Advances in molecular genetics, transgenic models, and gene therapy for the study of pulmonary diseases. Am J Respir Crit Care Med 151:2065-2069, 1995.
142. BeruBe KA, Quinlan TR, Moulton G, Hemenway D, O'Shaughnessy P, Vacek P and Mossman BT: Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos. Toxicol Appl Pharmacol 137:67-74, 1996.
143. Treadwell MD, Mossman BT and Barchowsky A: Increased neutrophil adherence to endothelial cells exposed to asbestos. Toxicol Appl Pharmacol 139:62-70, 1996.
144. BeruBe KA, Quinlan TR, Fung H, Magae J, Vacek P, Taatjes DJ, and Mossman BT: Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos. Am J Respir Cell Mol Biol 15:141-147, 1996.
145. Mossman BT, Surinrut P, Brinton BT, Marsh JP, Heintz NH, Lindau-Shepard B, and Shaffer JB: Transfection of a manganese-containing superoxide dismutase gene into hamster tracheal epithelial cells ameliorates asbestos-mediated cytotoxicity. Free Radic Biol Med 21:125-131, 1996.
146. Zanella CL, Posada J, Tritton TR and Mossman BT: Asbestos causes stimulation of the ERK-1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor. Cancer Res 56:5334-5338, 1996.
147. Chen Q, Marsh J, Ames B, and Mossman B: Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. Carcinogenesis 17:2525-2527, 1996.
148. Mossman BT, Kamp DW and Weitzman SA: Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers. Cancer Invest 14:466-480, 1996.
149. Fung H, Kow YW, Van Houten B, and Mossman BT: Patterns of 8-hydroxydeoxyguanosine (8OHdG) formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos. Carcinogenesis 18:101-108, 1997.
150. Fung H, Quinlan TR, Janssen YMW, Timblin CR, Marsh JP, Heintz NH, Taatjes DJ, Vacek P, Jaken S, and Mossman BT: Inhibition of protein kinase C (PKC) prevents asbestos-induced c-fos and c-jun protooncogene expression in mesothelial cells. Cancer Res 57:3101-3105, 1997.
151. Janssen YMW, Driscoll KE, Howard B, Quinlan TR, Treadwell M, Barchowsky A, and Mossman BT: Asbestos causes translocation of p65 protein and increases NF-?B DNA binding activity in rat lung epithelial and pleural mesothelial cells. Am J Pathol 151:389-401, 1997.
152. Goldberg JL, Zanella CL, Janssen YMW, Timblin CR, Jimenez LA, Vacek P, Taatjes DJ, and Mossman BT: Novel cell imaging approaches show induction of apoptosis and proliferation in mesothelial cells by asbestos. Am J Respir Cell Mol Biol 17:265-271, 1997.
153. Janssen YMW, Matalon S, and Mossman BT: Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS. Am J Physiol (Lung Cell & Mol Physiol) 273:L789-L796, 1997.
154. Mossman BT, Faux S, Janssen Y, Jimenez LA, Timblin C, Zanella C, Goldberg J, Walsh E, Barchowsky A, and Driscoll K: Cell signaling pathways elicited by asbestos. Environ Health Perspect 105(Suppl. 5):1121-1125, 1997.
155. Jimenez LA, Zanella C, Fung H, Janssen YMW, Vacek P, Charland C, Goldberg J, and Mossman BT: Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2. Am J Physiol (Lung Cell Mol Physiol) 273:L1029-L1035, 1997.
156. Mossman BT and Gee JB: Asbestos-related cancer and the amphibole hypothesis. The hypothesis is still supported by scientists and scientific data [letter; comment]. Am J Publ Health 87:689-690; discussion 690-691, 1997.
157. Davis WP, Janssen YMW, Mossman BT, and Taatjes DJ: Simultaneous triple fluorescence detection of mRNA localization, nuclear DNA, and apoptosis in cultured cells using confocal laser scanning microscopy. Histochem Cell Biol 108:307-311, 1997.
158. Wylie AG, Skinner HC, Marsh J, Snyder H, Garzione C, Hodkinson D, Winters R, and Mossman BT: Mineralogical features associated with cytotoxic and proliferative effects of fibrous talc and asbestos on rodent tracheal epithelial and pleural mesothelial cells. Toxicol Appl Pharmacol 147:143-150, 1997.
159. Janssen YMW, Timblin CR, Zanella CL, Jimenez LA, Mossman BT: Induction of gene expression by environmental oxidants associated with inflammation, fibrogenesis, and carcinogenesis. In: Oxidative Stress and Signal Transduction, HJ Forman, E Cadenas, eds., Chapman and Hall, New York, NY, pp. 387-414, 1997.
160. Mossman BT, Taishi P, Quinlan T, Timblin C, BeruBé K, Marsh JP, Jimenez LA, Vacek P, Janssen YMW: Molecular markers of cell proliferation and injury: correlations between in vitro observations and rodent inhalation studies using crocidolite and chrysotile asbestos. In: Correlations Between In Vitro and In Vivo Investigations in Inhalation Toxicology, Mohr U, Ed., ILSI Press, Washington, DC., pp. 172-181, 1997.
161. Alleman JE and Mossman BT: Asbestos revisited. Scientific Amer. pp. 70-75, July, 1997.
162. Timblin CR, Janssen YMW, Mossman BT: Free radical mediated alterations of gene expression by xenobiotics. In: Free Radical Toxicology, KB Wallace, ed., Taylor and Francis, Washington, DC., pp. 325-348, 1997.
163. Pache JC, Janssen YMW, Walsh ES, Quinlan TR, Zanella CL, Low, RB, Taatjes DJ, and Mossman BT: Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers. Am J Pathol 152:333-340, 1998.
164. Mossman BT and Churg A: State-of-the-Art: Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 157:1666-1680, 1998.
165. Fung H, Kow YW, Van Houten B, Taatjes DJ, Hatahet Z, Janssen YMW, Vacek P, Faux SP, and Mossman BT: Asbestos increases mammalian major AP-endonuclease (APE) gene expression, protein levels and enzyme activity in rat pleural mesothelial cells. Cancer Res 58:189-194, 1998.
166. BeruBe K, Mossman B, Quinlan T, and Taatjes D: Diverse microscopy imaging techniques for studies of asbestos-induced lung disease. Microscopy & Analysis (March), pp. 13-15, 1998.
167. Timblin CR, Janssen YMW, Goldberg JL, and Mossman BT: GRP78, HSP72/73, and c-jun stress protein levels in lung epithelial cells exposed to asbestos, cadmium, or H2O2. Free Radic Biol Med 24:632-642, 1998.
168. Quinlan TR, Hacker MP, Taatjes D, Timblin C, Goldberg J, Kimberley P, BeruBe KA, O'Shaughnessy P, Hemenway D, Torino J, Jimenez LA and Mossman BT: Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models. Free Radic Biol Med 24(5):778-788, 1998.
169. Driscoll KE, Carter JM, Howard BW, Hassenbein D, Janssen YMW, and Mossman BT: Crocidolite activates NF-?B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants. Environ. Health Perspect. 106(Suppl. 5):1171-1174, 1998.
170. Janssen YMW, Driscoll KE, Timblin CR, Hassenbein D, and Mossman BT: Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. Environ Health Perspect 106(Suppl. 5):1191-1195, 1998.
171. Timblin CR, Guthrie GD, Janssen YMW, Walsh ES, Vacek P, and Mossman BT: Patterns of c-fos and c-jun proto-oncogene expression, apoptosis, and proliferation in rat pleural mesothelial cells exposed to erionite or asbestos fibers. Toxicol Appl Pharmacol 151:88-97, 1998.
172. Barchowsky A, Roussel RR, Krieser RJ, Mossman BT, and Treadwell MD: Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos. Toxicol Appl Pharmacol 152:388-396, 1998.
173. Timblin C, BeruBe K, Churg A, Driscoll K, Gordon T, Walsh E, Cummins AB, Vacek P, and Mossman B: Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Res 58:4543-4547, 1998.
174. Timblin CR, Janssen-Heininger Y, and Mossman BT: Pulmonary reactions and mechanisms of toxicity of inhaled fibers, In: Toxicology of the Lung (DE Gardner, JD Crapo, and RO McClellan, eds.), Taylor & Francis, Washington DC, 3rd Ed, 1998.
175. Mossman BT: Effects on laboratory mammals and in vitro test systems, In: Environmental Health Criteria 203: Chryostile Asbestos, International Programme on Chemical Safety, World Health Organization, pp. 69-102, Geneva, 1998.
176. Driscoll K, Hassenbein D, Howard B, Carter J, Gauldie J, Janssen Y and Mossman B: Cytokines, oxidative stress and inflammation. In: Proceedings of the 6th International Inhalation Symposium "Relationships Between Respiratory Disease and Exposure to Air Pollution".
177. Janssen YMW, Macara I, and Mossman BT: Cooperativity between oxidants and tumor necrosis factor in the activation of NF-?B in lung epithelial cells: requirement of Ras/mitogen activated protein kinases in the activation of NF-?B by oxidants. Am J Respir Cell Mol Biol 20:942-952, 1999.
178. Zanella CL, Timblin CR, Cummins A, Jung M, Goldberg J, Raabe R, Tritton TR and Mossman BT: Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos expression and apoptosis. Am J Physiol (Lung Cell Mol Physiol) 277:L684-L693, 1999.
179. Robledo R and Mossman B: Cellular and molecular mechanisms of asbestos-induced fibrosis. J. Cell. Physiol. 180:158-166, 1999.
180. Poynter ME, Janssen-Heininger YMW, Buder-Hoffmann S, Taatjes DJ and Mossman BT: Measurement of oxidant-induced signal transduction proteins using cell imaging. Free Radic. Biol. Med. 27:1164-1172, 1999.
181. Rahman Q, Abidi P, Afaq F, Schiffmann D, Mossman BT, Kamp DW, Athar M. Glutathione redox system in oxidative lung injury. Crit Rev Toxicol. 29(6):543-568, 1999.
182. Robledo R and Mossman B: Cellular and molecular mechanisms of asbestos-induced fibrosis. J Cell Physiol 180:158-166, 1999.
183. Mossman BT: Environmental Pathology: New directions and opportunities: Toxicol Pathol 27:180-186, 1999.
184. Poynter ME, Janssen-Heininger YMW, Buder-Hoffmann S, Taatjes DJ and and Mossman BT: Measurement of oxidant-induced signal transduction proteins using cell imaging. Free Radic. Biol. Med. 27:1164-1172, 1999.
185. Robledo RF, Buder-Hoffmann SA, Cummins AB, Walsh ES, Taatjes D and Mossman BT: Increased phosphorylated ERK immunoreactivity associated with proliferative and morphologic lung alterations following chrysotile asbestos inhalation in mice. Am. J. Pathol. 156:1307-1316, 2000.
186. Shukla A, Timblin C, BeruBe K, Gordon T, McKinney W, Driscoll K, Vacek P, and Mossman BT: Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro. Am J Respir Cell Mol Biol. 23(2):182-187, 2000.
187. Jung M, Davis W, Taatjes D, Churg A, Mossman BT: Asbestos and cigarette smoke cause increased in apoptosis in rat bronchiolar epithelium. Free Radic. Biol. Med. 28:1295-1299, 2000.
188. Hessel PA, Gamble JF, Gee JBL, Gibbs G, Green FHY, Morgan WKC, and Mossman BT: Silica, silicosis, and lung cancer: a response to a recent working group report. J Occup Environ Med. 42(7):704-720, 2000.
189. Murthy SS, Shen T, De Rienzo A, Lee WC, Ferriola PC, Jhanwar SC, Mossman BT, Filmus J,Testa JR: Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma. Oncogene. 19(3):410-416, 2000.
190. Mossman BT: Mechanisms of action of poorly soluble particulates in overload-related lung pathology. Proceedings of the ILSI Workshop on the Relevance of the Rat Lung Response to Particle Overload for Human Risk Assessment, 23 March, 1998. Inhal Toxicol 12;101-108, 2000.
191. Fukagawa N, Timblin C, Buder-Hoffmann S, and Mossman BT: Strategies for evaluation of signaling pathways and transcription factors altered in aging. Antioxid Redox Signal. 2(3):379-389, 2000.
192. Shukla A, Timblin CR, Hubbard AK, Bravman J, and Mossman BT: Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the Activator Protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress. Cancer Res. 61: 1791-1795, 2001.
193. Buder-Hoffmann, Palmer C, Vacek P, Taatjes D and Mossman B: Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 24(4):405-413, 2001.
194. Timblin C, Robledo R, Rincon M, Cummins A, Pfeiffer L and Mossman B: Transgenic mouse models to determine the role of epidermal growth factor receptor (EGFR) in epithelial cell proliferation, apoptosis, and asbestosis. Chest 120:22S-24S, 2001.
195. Hubbard AK, Timblin CR, Rincon M, Mossman BT: Use of transgenic luciferase reporter mice to determine activation of transcription factors and gene expression of fibrogenic particles. Chest 120:24S-25S, 2001.
196. Timblin CR, Janssen-Heininger Y, and Mossman BT: Physical agents in human carcinogenesis. In: WB Coleman & GJ Tsongalis, eds., Molecular Basis of Human Cancer, Humana Press, Inc., Totowa, NJ, pp 223-232, 2001.
197. Johnson NF and Mossman BT: Dose, dimension, durability and biopersistence of chrysotile asbestos. The Canadian Mineralogist Spec. Publ. 5: pp. 145-154, 2001.
198. Shukla A, Timblin CR, Mossman BT and Hubbard A: The role of free radicals in asbestos- and silica-induced fibrotic lung diseases. In: Environmental Stressors in Health and Disease (Oxidative Stress and Disease Series/7), (J. Fuchs and L Packer, eds.), Marcel Dekker, Inc., pp. 185-202, 2001.
199. Taatjes DJ, Palmer CJ, Pantano C, Buder-Hoffmann S, Cummins A and Mossman BT: Laser-based microscopic approaches: Application to cell signaling in environmental lung disease. Biotechniques 31:880-894, 2001.
200. Shi X, Ding M, Yucesoy B, Mossman B and Vallyathan V: Diseases caused by silica: Mechanisms of injury and disease development. Int. Immunopharmacology (In Press, 2001).
201. Manning CB, Vallyathan V, and Mossman BT: Diseases caused by asbestos: Mechanisms of injury and disease development. Int. Immunopharmacology (In Press, 2001).
202. Hubbard A, Timblin CR, Shukla A, Rincon M, and Mossman BT: Activation of NF-kB-dependent gene
expression by silica. Am. J. Physiol. (Lung Cell Mol. Physiol.) (In Press, 2001).
203. BeruBe KA, Murphy SA, Jones TP, Timblin C, Hemenway D, Mossman BT and Richards RJ: Characterisation of airborne particulate matter and related mechanisms of toxicity. In: J Ayres, R Maynard, R Richards, eds. Air Pollution and Health, Vol. 4, Imperial College Press, London (In Press).
204. Mossman BT, Hubbard A, Shukla A, and Timblin CR: Role of mitogen activated protien kinases (MAPK), early response protooncogenes, and activator protein (AP-1) in cell signalling by asbestos. Proceedings of the 7th International Meeting on Particle Toxicology. Inhal Toxicol (In Press).
205. Fukagawa NK, Li M, Timblin CR and Mossman BT: Modulation of cell injury and survival by high glucose and advancing age. Free Radic. Biol. Med. (In Press), 2001.
206. Lounsbury KM, Stern M, Jaken S, and Mossman BT: Increased localization and substrate activation of protein kinase C? in lung epithelial cells following exposure to asbestos. (Submitted)
207. Vianale G, Mutti L, Timblin C, Berlanger I, MacPherson M, and Mossman BT: Synergistic effects of onconase and extracellular signal-regulated kinase (ERK) inhibition on killing of human mesothelioma cells. (Submitted)

Books/Series:
1. Mossman BT and Begin RO (eds.): Effects of Mineral Dusts on Cells, NATO ASI Series H: Cell Biology, Springer-Verlag, Berlin, pp.1-470, 1989.
2. Guthrie GD, Jr, and Mossman BT (eds.): Health Effects of Mineral Dusts, Reviews in Mineralogy, Vol. 28 (Series Editor: Paul H. Ribbe), Mineralogical Society of America, Washington, D.C., pp. 1-584, 1993.
3. Mossman BT: Guest Editor. Forum on “Signal Transduction by Oxidants: Look who’s talking”. Free Radic. Biol. Med. 28, 2000.
4. Taatjes & Mossman: Cell Imaging Techniques (Methods in Molecular Biology), Humana Press, In Press.

Invited Presentations:
"Interaction of crocidolite with the tracheobronchial epithelium in organ cultures." Proc. Soc. Exp. Biol., Med., Champlain Division, November 15, 1975.
"Long-term maintenance of hamster tracheal organ cultures." GAP Workshop on Tissue Culture Models to Study Cystic Fibrosis. Lake Placid, NY, October 12-14, 1977.
"Interaction of environmental particulates with the tracheobronchial epithe-lium." School of Public Health, Harvard University, Boston, MA, Jan 30, 1978.
"Models of respiratory carcinogenesis." Dartmouth Medical School, Hanover, NH, October 15, 1978.
"Organ culture as a tool to study environmental carcinogenesis." Workshop on Teaching of Environmental Pathology, Aspen, CO, July 29-August 3, 1979.
"Comparative cytotoxicity of chrysotile and crocidolite asbestos in hamster tracheal epithelial cells." Gordon Conference: Pulmonary Biology: Lung Injury, August 11-15, 1980.
"Interaction of minerals with cell membranes." Clay Minerals Society, Waco, TX, October 5-9, 1980.
"Asbestos and carcinogenesis-mechanisms of cellular injury." Department of Pulmonary Medicine, Yale University,
New Haven, CT, January 21, 1981.
"Mechanisms of asbestos carcinogenesis." American Health Foundation, Naylor--Dana Institute, Valhalla, NY, January 23, 1981.
"Studies of cellular mechanisms in asbestos-induced disease." State University of New York, Department of Health Division of Laboratories and Research. Albany, NY, June 20, 1981.
"Asbestos-induced cancers." Key note speaker. Annual Meeting of the American Cancer Society, Vermont Division, Montpelier, VT, October 15, 1981.
"Mechanisms of asbestos-induced carcinogenesis in hamster trachea." 12th Conference on Environmental Toxicology,
Dayton, Ohio, November 3, 1981.
"Mechanisms of asbestos and nonasbestiform particles and fibers in bronchogenic carcinoma". 4th Annual RMCOEH Occupational and Environmental Health Conference on Health Issues Related to Metal and Nonmetallic Mining, Park City, Utah, April 7-9, 1982.
"Asbestos-mechanisms of cytotoxicity and carcinogenicity in the respiratory tract". School of Public Health. University of California at Berkeley, June 11, 1982.
"In vitro studies pertaining to ingested asbestos", Summary Workshop on In-gested Asbestos, US EPA, Cincinnati, OH, October 13-14, 1982.
Session chairperson of session on "Chemical-induced injury" and speaker: International Conference on Beta Cell Injury, Juvenile Diabetes Founda-tion, Princeton, NJ, October 27-30, 1982.
"Alternate approaches to animal testing: tracheal organ culture" Battelle Laboratories, Columbus, OH, March 29, 1983.
"Mechanisms of asbestos carcinogenesis" University of South Alabama, College of Medicine, Graduate Program in Basic Medical Sciences, Mobile, AL, November 10, 1983.
"Cocarcinogenesis and tumor promotion by particulates and fibers in the respiratory tract" Conference on Tumor Promotion and Enhancement in Human and Experimental Respiratory Tract Carcinogenesis, US EPA, Williamsburg, VA, June 17-20, 1984.
"In vitro studies on asbestos-induced carcinogenesis" W. Alton Jones Cell Science Center, Lake Placid, NY, July 17, 1984.
"Mechanisms of cell damage and carcinogenesis by asbestos" National Institute of Occupational Safety and Health, Morgantown, WV, September 10, 1984.
"Cellular mechanisms of damage and carcinogenesis by asbestos and polycyclic aromatic hydrocarbons" National Institute of Environ-mental Health Sci-ences, Research Triangle, NC, January 17, 1985.
"Mechanisms of asbestos-induced toxicity and carcinogenicity" Department of Pathology, State University of New York at Syracuse, March 18, 1985.
"Pathogenesis of asbestos-associated disease" Division of Pulmonary Medicine, Yale University, New Haven, CT, March 27, 1985.
"Oxygen free radicals in asbestos-induced lung injury" AIR Seminar Series, University of Rochester Medical Center, Rochester, NY, April 30, 1985.
"Role of active oxygen species in asbestos-associated toxicity" Fine Particles Symposium, Miami, Florida, April 22,
1985
"In Vitro approaches to study of respiratory tract cancers" National Insti-tutes of Health, Interagency Collaborative Group on Environmental Carcino-genesis, Bethesda, Maryland, October 16, 1985.
"Mechanisms of asbestos-associated carcinogenesis", New York University Medical Center, Division of Environmental Medicine, Sterling Forest, New York, October 23, 1985.
"Importance of fiber length and dimension in asbestos induced toxicity and carcinogenesis", U.S. Army, Department
of Toxicology, Aberdeen, Maryland, December 18, 1985.
"Mechanisms of asbestos carcinogenesis", Session-In-Depth on Mechanisms of Cell-Toxicant Interaction, 37th Annual Meeting of the Tissue Culture Association, Chicago, IL, June 7, 1986.
"Oxygen free radicals as causative factors in asbestosis", University of Connecticut, Department of Laboratory Medicine, Farmington, Connecticut, June 23, 1986.
"Approaches to prevention of asbestos-induced fibrotic lung disease in rats using administration of polyethylene (PEG)-conjugated scavengers of active oxygen species", ENZON Conference on "Modified Enzymes in Free Radical Research", Princeton, N.J., July 19, 1986.
"Mechanisms of asbestos-induced carcinogenesis," Defense Research Institute, Seminar on "Asbestos Medicine," Boston, MA, November 21, 1986.
"Role of oxygen free radicals in asbestos-induced lung disease," Conference on "Oxygen Radicals and Antioxidants in Cancer and Aging," University of California at Berkeley, February 6-7, 1987.
"Mechanisms of pulmonary carcinogenesis by inorganic particles," Workshop on "Mechanisms and Distributions of Environmental Disease," Montreal, Canada, April 28, 1987.
"Asbestos fibers and disease," Policy Forum: Asbestos in Commercial Buildings, Urban Land Institute, Washington,
D.C., June 16, 1987.
"Mechanisms of asbestos fibers in disease," Symposium on Scientific Advances in Environmental Medicine, New York University Institute of Environmental Medicine, New York, New York, October 29-30, 1987.
Invited discussant, "Oxygen radicals in xenobiotic-induced tissue injury", UpJohn - U.C.L.A. Symposium on Oxy-Radicals in Molecular Biology and Pathology. Park City, Utah, January 24-30, 1988.
"Free radical mechanisms in asbestos-induced diseases. Symposium on Free Radical Mechanisms in Pathogenesis, Annual meeting of the Society of Toxicology, Dallas, Texas, February 16-19, 1988.
Invited speaker, B.O.M.A. International Asbestos Management Seminar, New York, New York, March 10-11, 1988
Invited participant, International Symposium on "Biological Interaction of Inhaled Mineral Fibers and Cigarette Smoke," Battelle-Seattle, Washington, April 10-14, 1988. (Did not attend due to scheduling conflict.)
"Mechanisms of cell damage and proliferation by asbestos". W. Alton Jones Cell Science Center, Lake Placid, N.Y., May 10, 1988.
Invited participant, Proctor and Gamble Workshop on "Future Directions in Research on Toxicology of the Respiratory Tract", Cincinnati, OH, October 17-19, 1988.
"Fibers", meeting on "Biology, Toxicology and Carcinogenesis of the Respiratory Epithelium", Albuquerque, NM, November 14-16, 1988.
"Factors influencing individual responses to asbestos", Symposium on "Health Aspects of Asbestos in Buildings", Energy and Environmental Policy Center, John F. Kennedy School of Government, Harvard University, Cambridge, MA, December 14-16, 1988.
"Mechanisms of asbestos-induced diseases", Wadsworth Center for Laboratories and Research Scientific Seminar Series, State of New York Department of Health, Albany, N.Y., January 24, 1989.
"The medical case from the doctor's standpoint", Asbestos in Buildings: The Laws, the Costs, the Solutions, Law Journal Seminars-Press, New York, New York, April 13-14, 1989
"Asbestos toxicology", Toxicology Update, Current Concepts in Inhalation Toxicology, Johns Hopkins University, April 24-26, 1989 (Did not attend due to schedule conflicts).
Session leader on research directives and invited speaker, N.I.E.H.S. workshop on Research Needs in Fiber Toxicology, Research Triangle, NC, July 10-12, 1989.
"Antioxidant enzyme defense mechanisms in asbestos-related lung injury", Chicago Lung Association Conference on Occupational Lung Disease, October 19-22, 1989.
"Asbestos: scientific developments and public policy", American Industrial Hygiene Association, Meriden, CT, March 14, 1990.
"Mechanisms of asbestos-induced lung disease", Department of Pathology, Mount Sinai School of Medicine, New York, NY, March 19, 1990.
"Role of oxy-radicals in rodent cells", Cold Spring Harbor Conference on Mechanisms of Fiber Cytotoxicity and Carcinogenesis, Banbury Conference Center, Long Island, NY, March 20-22, 1990.
"Active oxygen species in asbestos-induced cell damage and disease", Symposium on "Free radical mechanisms of tissue injury", Annual meeting of the American Chemical Society, Boston, MA, April 22, 1990.
"Mechanisms of asbestos-related diseases", Society for Risk Analysis', Forum on Risk of Indoor (Asbestos) Building Materials, Washington, D.C., May 7-8, 1990.
"Mechanisms of asbestos-induced lung disease", Symposium on "Particle-Lung Interactions: Overload Related Phenomena", Rochester, NY, May 17-18, 1990.
"Asbestos: scientific developments", Clinical Research Institute of Montreal, Montreal, Canada, May 22, 1990.
"Asbestos: an overview on mechanisms of action in the causation of lung diseases", Symposium on "Exogenous and Endogenous Factors as Major Cancer Risks in Carcinogenesis", Eighty-first Annual Meeting of the American Association of Cancer Research, Washington, D.C., May 26, 1990.
"Health effects of low level exposure" Workshop on Asbestos in Buildings, Canadian Centre for Occupational Health and Safety, Laval, Quebec, September 11, 1990.
"Recent information on potential health risks from exposure to asbestos", American Association of School Administrators "I Care" Conference, Hyatt Regency on Capitol Hill, Washington, D.C., September 13, 1990.
Workshop on "Pleural cell biology in health and disease", Session Chairman, N.H.L.B.I., Bethesda, MD, October 1, 1990.
"Risks from asbestos exposure" Annual Meeting of the Society for Risk Analysis. New Orleans, LA, October 7, 1990.
"The risks of asbestos in buildings: the need for national policy." Brookings Institute, Washington, D.C., November 7, 1990.
Visiting Pulmonary Scholar Program sponsored by Burroughs Wellcome; the Chemical Industry Institute of Toxicology; Duke University; the U.S. Environmental Protection Agency; the National Institute of Environmental Health Sciences; North Carolina State University Veterinary School; and the University of North Carolina. Raleigh, NC, February 5-7, 1991.
"Asbestos and lung disease", Grand Rounds, St. Lukes/Roosevelt Hospital, Dept. of Medicine, New York, NY, February 13, 1991.
"Oxidant-induced cell injury by asbestos", Department of Pathology, Baylor College of Medicine, Houston, TX, March 21, 1991.
"Molecular biology of asbestos interactions with tracheal epithelial cells and lung fibroblasts", Wayne State University, Detroit, Michigan, April 8, 1991.
"Oxidants, antioxidants and asbestos-induced lung disease", Institut Lady Davis de Recherches Medicales, Montreal, Canada, April 16, 1991.
"Oxidants, antioxidants and asbestos-related lung disease", American Health Foundation, Valhalla, NY, May 9, 1991.
Chair and session summarizer, "Mechanisms of asbestos-induced lung disease", American Thoracic Society - American Lung Association Annual Meeting, Los Angeles, CA, May 14, 1991.
Invited speaker - 10th International Symposium for Society of Toxicologic Pathologists, Pulmonary Toxicologic Pathology, "Mechanisms of asbestos-induced lung injury in a rat inhalation model of disease", June 4, 1991.
"Oxidant injury and asbestos-induced lung disease", National Institute of Environmental Health Sciences, Research Triangle Park, NC, September 3, 1991.
Session Chair and invited lecturer "Oxidants and Enzyme Induction", Fourth International Conference on Environmental Lung Disease: At home, at work: Mechanisms, manifestations and management, Montreal, Canada, September 25-28, 1991.
"Mechanisms of asbestos-induced lung cancer and mesothelioma", American Society of Clinical Oncology, Educational Workshop, Miami, FL, November 8, 1991.
Invited participant and rapporteur, Workshop on "Approaches to evaluating the toxicity and carcinogenicity of man-made fibers", sponsored by Duke University Center for Extrapolation Modeling, the Thermal Insulation Manufacturers Association and the U.S. Environmental Protection Agency, Durham, NC, November 11-13, 1991.
"Approaches to testing synthetic fibers for disease potential" Toxicology Division, Dow Chemical Company, Midland, MI, Jan 20, 1992.
"Biochemical mechanisms in asbestos-related carcinogenesis and fibrosis" Department of Biochemistry, Loyola University of Chicago, IL, February 10, 1992.
"Asbestos", Invited speaker at Symposium on "How well does environmental policy track science", Annual meeting of the Am. Assoc. for Advancement of Science, Chicago, IL, February 11, 1992.
Invited Speaker, "Health effects of fibrous materials" Workshop on Interaction of Glass Surfaces with Chemical and Biological Environments, NSF/University Center for Glass Research, Bethesda, MD, March 5-6, 1992.
Co-Chair and presenter, Mini-symposium: "Adaptive responses to injury", American Assoc. Pathology, FASEB Meetings, April 9, 1992.
Invited Speaker, "Mechanisms of asbestos-induced lung disease and preventive approaches", National Center of Occupational Health, Johannesburg, South Africa, March 28, 1992.
Invited Speaker, "Mechanisms of asbestos-induced free radical production", Mobil Environmental Technical Center, Princeton, NJ, April 27, 1992.
Invited Speaker, "Effects of asbestos and free radicals on cellular proliferation", National Cancer Institute Division of Experimental Pathology, National Institutes of Health, Besthesda, MD, May 7, 1992.
Invited Speaker, "Cancer risks of asbestos", Symposium on Risk Assessment of Carcinogens in the Workplace and Environment, Annual meeting of the American College of Occupational Medicine, Washington, DC; May 8, 1992.
"Sensitivity of human mesothelial cells to asbestos and oxidants", Symposium on "Pleural disease", American Thoracic Society-American Lung Association International Conference, Miami, FL, May 18, 1992.
"Mechanisms of asbestos toxicity and health risks" American Society of Testing Materials (ASTM)-EPA workshop, Johnson VT, July 12-14, 1992.
Invited plenary speaker on "Asbestos-recent scientific developments", Joint Scientific Session of the Pennsylvania and New Jersey Thoracic Societies and the Eastern Division of the ATS, 100th Anniversary, Philadelphia, PA Sept. 11-12, 1992.
Invited Faculty, Law Institutes Program on Asbestos Medicine. "What do animal inhalation experiments tell us about human disease?" Defense Research Institute, Chicago, IL, October, 1992.
"Molecular regulation of cell proliferation by asbestos", Department of Biochemistry and Cell Biology, Albany Medical College, Albany, NY, February 1, 1993.
"Mechanisms of asbestos-induced lung disease", Division of Pulmonary Medicine, Department of Internal Medicine, Yale University, New Haven, CT, September 30, 1993.
Invited session speaker "Pathology of lung injury", American Society for Investigative Pathology, FASEB meetings, New Orleans, LA, March 31, 1993.
Distinguished Professor lectureship, Jefferson Medical College, Division of Environmental Medicine and Toxicology, April 28-29, 1993.
"Molecular mechanisms of asbestos-induced lung disease", Seminar series on Pulmonary Biology and Medicine, M.D. Hershey Medical Center, Penn State, Hershey, PA, May 7, 1993.
"Protooncogene induction by asbestos", 2nd International Mesothelioma Workshop, San Francisco, CA, May 15, 1993.
Session Co-chair and invited speaker, "Tissue structural cells as effectors of response to inhaled environmental and occupational pollutants", American Thoracic Society/American Lung Association International Conference, May 16-19, 1993.
Session Co-chair, "Molecular mechanisms of cell proliferation in lung", American Thoracic Society/American Lung Association International Conference, May 16-19, 1993.
Invited Speaker, "Molecular mechanisms of cell proliferation and carcinogenesis by asbestos", Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, July 14, 1993.
Invited plenary speaker on "The toxicology of serpentine and amphibole asbestos", Annual meeting of the American Institute of Chemists/American Chemical Society, 70th National Meeting, Chicago, IL August 24, 1993.
Invited Speaker and Session Chair, Symposium on "Cell signalling and the molecular stress responses", Lake Placid, NY, Sept. 23-26, 1993.
"Molecular mechanisms of asbestos-induced diseases", Pharmacology and Toxicology Seminar Series, Dartmouth-Hitchcock Medical Center, Hanover, NH, January 19, 1994.
Invited Faculty, Workshop on "Talc: Consumer Uses and Health Perspectives", International Society of Regulatory Toxicology and Pharmacology and the FDA, National Institutes of Health, Bethesda, MD, January 31-February 1, 1994.
Invited Speaker, Gordon Conference on "Oxygen Radicals and Biology", Ventura, CA, Feb. 6-11, 1994.
Invited Speaker, Wyeth Ayerst Drug Safety Symposium on "Modern Trends in Safety Assessment of Drugs", Chazy, NY, May 9, 1994.
"Molecular mechanisms of asbestos-induced lung diseases", Toxicology Scholars Colloquium, University of Connecticut at Storrs, Center for Biochemical Toxicology, May 12-13, 1994.
Session Co-Chair and Presentor, Symposium on "Transmembrane Signalling and Intracellular Regulation Mechanisms, American Thoracic Society/American Lung Association, 1994 International Meeting, Boston, MA, May 24, 1994.
Invited Speaker, Symposium on "Mesothelioma and Mesothelioma Cells", American Thoracic Society/American Lung Association 1994 International Meeting, Boston, MA, May 24, 1994.
Session Chair, "Pneumoconiosis: Basic Mechanisms", American Thoracic Society/American Lung Association 1994 International Meeting, Boston, MA, May 23, 1994.
"Molecular Mechansims of Asbestos-Induced Disease", Sealy Center for Molecular Biology, University of Texas at Galveston, October 4, 1994.
"Molecular Mechanisms of Asbestos Interactions with Cells", Pulmonary Division, University of Texas at Houston, October 5, 1994.
Invited Speaker "Inhalation Models to Explore Mechanisms, Prevention and Treatment of Pulmonary Fibrosis", Wyeth Ayerst Scientific Symposium on Pharmaceutical Aspects of Drug Delivery to the Lung, State
University of New York at Plattsburgh, October 11, 1994.
Invited Plenary Lecturer, "Role of reactive oxygen and nitrogen species in cell signalling and proliferation by asbestos, 43rd Annual Meeting of the Radiation Research Society, San Jose, CA, April 1-6, 1995.
Invited Session Chair and Guest, "Meet the Researchers", Pulmonary Pathobiology Subsection, Experimental Biology '95, Atlanta, GA, April 9-13, 1995.
Invited Lecturer, "An update on asbestos", Robert Wood Medical Institute, Rutgers University, Piscataway, NJ, May 11, 1995.
Invited Speaker and Session Chair, Annual Meeting of the American Thoracic Society, Miami, FL, May 20-24, 1995.
Invited Speaker, Keystone Symposium on "Oxidant Stress: from Molecules to Man", Santa Fe, New Mexico, January 8-14, 1996.
Invited Session Chair, Gordon Conference on "Oxygen Radicals and Biology", Ventura, CA, February 14-19, 1996.
Invited Lecturer, Center for Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, April 4, 1996.
Session Chair and Invited Speaker, Annual Meeting of the American Thoracic Society, New Orleans, LA, May 10-15, 1996.
Invited Speaker, Oxygen Society Meeting '96, Miami Beach, FL, November 21-25, 1996.
Invited Symposium Speaker, Society of Toxicology Annual Meeting, Cincinnatti, OH, March 9-12, 1997.
Organizer and Chair, Symposium on "Oxidative Mechanisms of Cell Signalling and Repair in Disease", American Society for Investigative Pathology, Experimental Biology '97, New Orleans, LA, April 6-9, 1997.
Organizer and Chair, Trends in Experimental Pathology Symposium, "New developments in cell imaging techniques for detection of cell injury and disease", American Society for Investigative Pathology, Experimental Biology '97, New Orleans, LA, April 6-9, 1997.
Organizer, Workshop on "Environmental Pathology: New Directions and Opportunities, American Society for Investigative Pathology, Experimental Biology '97, New Orleans, LA, April 6-9, 1997.
Invited Lecturer and Honorary Membership Award, The Oxygen Society of Greater Washington, DC, Inc., Annual Meeting, June 10, 1997.
Invited Lecturer, Yale University Symposium on Pulmonary Biology and Environmental Lung Disease, New Haven, CT, October 22, 1997.
Invited Symposium Speaker, Annual Meeting of the Society for Gerontology Research, Cincinnatti, OH, Nov. 12-17, 1997.
Invited Speaker, University of California @ Davis, Center for Comparative Respiratory Biology and Medicine, Pulmonary Seminar Series, "Cell Signalling Cascades in Oxidant-Induced Lung Injury and Apoptosis", May 1, 1998.
Invited Speaker, Columbia University; Division of Environmental Health Sciences. "Cell signalling events regulating apoptosis and proliferation by oxidant stresses in mesothelial and pulmonary epithelial cells", May 13, 1998.
Invited Speaker, Wayne State University, NIEHS Center Seminar Series: "Cell signalling by oxidant stresses in lung", May 14, 1998.
Invited Speaker, University of Rochester Division of Environmental Health Sciences: "Cell signalling by minerals and oxidants in environmental lung disease", May 21, 1998.
Invited Speaker, University of Pennsylvania, "Cell signalling mechanisms in environmental lung disease", September 25, 1998.
Program Chair, Oxygen '98, Annual Meeting of the Oxygen Society, Washington, DC, November 19-23, 1998.
Invited Speaker, NIEHS/NHLBI "Apoptosis and Growth Factors/Signal Transduction Pathways: Basic Biology and Toxicology", Raleigh, NC, April 19-21, 1999.
Invited Speaker, Department of Environmental Health, Harvard School of Public Health, "Cell signalling by environmental particulates", May 18, 1999.
Co-leader (with Mark Van Baalen and Carl Francis, Harvard University), "Mineralogy, Petrology and Health Issues at the Ultrameric Complex, Belvidere Mountain, VT", New England Intercollegiate Geological Conference, October 1-4, 1999.
Invited Speaker, Department of Cell and Molecular Biology, Loyola University, "Cell Signalling by Minerals and Oxidant Stress", April 7, 2000.
Session Chair and Speaker, "Fibrosis - inflammation, oxidants and cytokines", Gordon Conference on Mechanisms of Toxicity, Plymouth State College, Plymouth, NH, July 23-28, 2000.

University Activities:

Animal Care Committee, Given Institute
Admissions Committee for the Medical College
Steering Committee, Cell Biology Program
Admissions Committee, Cell Biology Program
Graduate Education Coordinator for the Department of Pathology
Search Committee for Chairman of Pediatrics
Evaluation Committee for Chairman of Biochemistry
Senate Committee on Research and Scholarship
Search Committee for Dean, College of Agriculture and Life Sciences
Self-Study Committee on Reaccreditation
Evaluation for Chairman of Pharmacology
Hearing Officer, Office of Affirmative Action
Task Force on Research and Scholarship
Given Asbestos Management Task Force

Other Activities:
Citizens for Responsible Growth: Head, Steering Committee (1977-1978)
Board of Governors, Medical Center Hospital of Vermont, Burlington (1987-1990)
Delta Delta Delta Alumni Chapter
Ambassador, Flynn Theatre for the Performing Arts (1990)
Champlain Valley Junior Service League

Research Support:

Ongoing or Completed in the past 3 Years:

"Mechanisms of Cell Replication in Asbestos Cancers"
NIH R01 ES O6499 Period: 9/1/93 - 8/31/99
The major goals of this project are: 1) To determine the mechanisms of transcriptional activation of c-fos and c-jun by asbestos, refractory ceramic fibers and glass; 2) to determine whether fiber geometry, size or type dictates increased gene expression of c-fos and/or c-jun in tracheal epithelial and mesothelial cells; 3) to transfect an AP-1 reporter gene into HTE cells to determine if increases in gene expression are observed after exposure of transfected cells to asbestos or H2O2; 4) to determine if asbestos and nonasbestos fibers cause increased incorporation of 5-bromodeoxyuridine in cells in vitro and in lungs of rats.

"Molecular Signalling by Oxidant Stress in Lung Epithelium"
2R01 HL39469-10A1 Period: 06/01/98 - 05/30/01
The major goal of this work is to determine whether asbestos and silica activate the MAPK cascade by oxidant-dependent mechanisms and whether transgenic mice with mutant MEK1 develop fibrosis to the same extent as transgene-negative littermates.
The Program Project (Project #1) below is a continuation of these research goals.

“Signaling in Epithelial Injury, Proliferation and Fibrosis” (B. Mossman = Proj. Dir.)
NIH PO1 HL6767004-01 Period: 06/01/01 – 03/31/06 TDC Entire Project $7,578,439
Project 1: “MAPK Signaling in Injury, Proliferation & Fibrosis” (B. Mossman, Project Leader)
FTE: 20% ($150,000)
Project 3: "Protein Kinase C and MAPK in Epithelial Responses" (B. Mossman, Project Leader)
FTE: 20% ($149,039)
Core A: "Administrative Core" (B. Mossman, Core Leader) FTE: 10% ($81,035)

"EGFR Signalling Pathways by Particulates in Lung Disease"
NIH 1R01 ES09213-01 Period: 9/30/97 - 09/29/01
The major goals of this work are to determine if interaction of asbestos fibers with lung epithelial cells is through the Epidermal Growth Factor Receptor, which then triggers MAPK activity and apoptosis.

"Asbestos and NO2 in Environmental Lung Disease"
NIH RO1 ES09673-01 (Nicholas Heintz, PI) Period: 08/15/98 - 07/31/02
The goal of this research is to determine if these agents have similar and additive signalling events and transcription factor activation (E2F, AP-1, NF-kB) in murine epithelial cells and transgenic models of altered p21 and p16 gene expression.

"The Nature of Lung Antioxidant Defense Mechanism"
NIH R01 HL56421 (Ye-Shih Ho, PI) (Subcontract) Period: 08/1/96 - 07/31/00
The major goal of this project is to determine if pulmonary inflammation and fibrosis are increased in transgenic "knockout" mice deficient in antioxidant enzymes.

"Asbestos-Induced Oxidative DNA Damage and Repair"
NIH ESO7038 (Bennett Van Houten, PI) (subcontract) Period: 02/01/94 - 01/31/00
The major goal of this project is to determine if oxidative DNA lesions induced in human pleural and rat mesothelial cells by asbestos mimic those induced by active oxygen species and are diminished by antioxidants and iron chelators.

NIH "Environmental Pathology Training Grant" (BT Mossman, Director)
PHS T32 ESO7122-15 Period: 07/01/82 - 06/30/02
The major goal of this project is to provide graduate training in environmental pathology. Seven predoctoral and two postdoctoral positions are funded annually.

Past:

American Cancer Society, Institutional Research Award (9/1/82-8/31/83) "Compara-tive interactions of methylnitrosoureas with the DNA of pancreatic beta cells and fibroblasts" Total $7,500. PI - 5% FTE.
ADA (8/1/82-7/30/84) "Diabetogenic chemicals: mechanisms of tropism for and damage to pancreatic beta cells" Total $49,877; first year $24,607. PI - 15% FTE (Returned 2/1/83 because of overcommitments)
NIH NIOSH (9/1/78-8/31/82) "Carcinogenic mechanisms of asbestos" Total $397,899. PI - 50% FTE
NIH NIAMDD (7/1/79-6/30/82) "Establishment of insulin-secreting cell lines" Total $101,980. PI - 30% FTE (Young Investigator Grant)
NIH NCI (7/1/82-8/30/85) "Role of minerals as cofactors in bronchogenic car-cinoma" Total $350,132; first year $108,444. PI - 30% FTE
Parker B. Francis Foundation (7/1/82-6/30/85) Postdoctoral fellowship - M.A. Shatos $63,174; first year $20,566. Program Director
American Cancer Society (1/1/83-12/31/85) "Fiber-cell interaction in broncho-genic carcinoma" Total $332,280; first
year $98,444. PI - 30% FTE
NIH NIEHS (2/1/83-1/31/86) "N-nitroso compounds: Mechanisms of damage to beta cells" Total $327,306; first
year $96,283. PI - 20% FTE
NIH NCI (9/1/85-8/30/88) "Oxygen radicals in mineral damage/tumor promotion", Total $347,508, first year $106,580. PI - 30% FTE
NIH NIEHS (2/1/86-1/31/89) "Preventive approaches to mineral-induced fibrosis" Total $328,339; first year $104,355. PI - 50% FTE
NHLBI (12/1/86-11/30/91) Pulmonary SCOR - Occupational and Immunologic Lung Disease, Director Project 05, "Preventive approaches to asbestosis," (current year $62,656) 15% FTE
NATO Advanced Research Workshop grant (7/1/88-12/30/88), "Effects of mineral dusts on cells", Total $22,500.
NIH NHLBI/NIEHS/NCI 9/1/88-8/31/89) Conference grant, "Workshop on effects of mineral dusts on cells". Total $28,000.
American Cancer Society (6/1/89-6/30/90) Fellowship for Susan Edmondson, Total $1,200.
Howard Hughes Helix Award (1/1/90 - 12/31/90). Undergraduate support for Kaaren Haldeman, Total $800.
E.P.A. (9/1/91 - 12/31/94). "Lung Defense Mechanisms after Occupational and Environmental Exposure to Asbestos", PI, 15% FTE, $450,422 TDC, $150,000 - Current Year Total Costs.
NIH NHLBI (4/1/93 - 3/30/97) "Molecular Biology of Lung Antioxidant Enzyme Regulation", PI, 40% FTE, ($168,887) - Current Year Direct Costs.
NIH NIOSH (10/1/94 - 9/30/97) "Stress Genes as Biomarkers of Mineral Dust Exposure", Advisor to Dr. Cynthia R. Timblin for Special Emphasis Career Development Award, ($50,000)- Current Year Direct Costs.
Parker B. Francis Foundation for Pulmonary Research (Y. Janssen, PI); (07/01/95 - 06/30/98); ADC $29,875 "Molecular pathways of proliferation and inflammation activated in lung epithelial cells by reactive oxygen and nitrogen species"
NIH 1 R13HL61258-01 (11/19/98 - 11/23/98), 1998 Oxygen Society Meeting Conference Grant. TDC $ 39,928. NIH NIEHS ESO7038 (2/1/94-1/31/99) "Asbestos-Induced Oxidative DNA Damage and Repair", Bennett Van Houten, P.I., Subcontract, ADC $44,239.
NIH R01 HL56421 (8/1/96 - 7/31/00) "The Nature of Lung Antioxidant Defense Mechanisms", Y-S Ho, PI, (Subcontract), ADC $25,505.
NIH 1 R01 ESO6499 (9/1/93 - 8/31/99) "Mechanisms of Cell Replication in Asbestos Cancers", (PI), ADC $126,262.