Selected Publications

(click here for Dr. Howe's MyNCBI bibliography)

  1. Cunniff, B., McKenzie, A., Heintz, N.H., and Howe, A.K. (2016). Localized energy sensing targets mitochondria to the leading edge of migrating cells. Mol. Biol. Cell. 27:2662-74
  2. Weivoda, M.M., Ruan, M., Hachfield, C.M., Pederson, L., Howe, A.K. , Davey, R.A., Zajac, J.D., Kobayashi, Y., Williams, B.O., Westendorf, J.J., Khosla, S., and Oursler, M.J. (2016). Wnt signaling inhibits osteoclast differentiation by activating canonical and cAMP/PKA pathways. J. Bone Mineral Res. 31:65-75.
  3. Rittiluechai, K., Ji, Y., Lounsbury, K., Howe, A., and Vershraegen, C. (2015) Ovarian Cancer in ‘International Manual of Oncology Practice (iMOP) – Principals of Medical Oncology’ (de Mello, Taveres, and Mountzios, (eds)), pp. 393-434 (Springer, pub.)
  4. Mirando, A.C., Fang, P., Williams, T.F., Baldor, L.C., Howe, A.K., Ebert, A.M., Wilkinson, B., Lounsbury, K.M., Guo, M., and Francklyn, C.S.. (2015). Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci. Rep. 14:13160.
  5. Deming, P.B., Campbell, S.L., Stone, J.B., Rivard, R.L., Mercier, A.L., and Howe, A.K.. (2015) Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). J. Biol. Chem. 290:5783-96.
  6. Verschraegen, C., Lounsbury, K., Howe, A., and Greenblatt, M.. (2015) Therapeutic implications for ovarian cancer emerging from the Cancer Genome Atlas. Trans. Cancer. Res. 4:40-59.
  7. Langevin, H.M., Nedergaard, M., and Howe, A.K.. (2013) Cellular control of connective tissue matrix tension. J. Cell. Biochem 114:1714-9.
  8. Abbott, R.D., Koptiuch, C. Iatridis, J.C., Howe, A.K., Badger, G.J., Langevin, H.M.. (2013) Stress and matrix-responsive cytoskeletal remodeling in fibroblasts. J. Cell. Physiol 228:50-7. PMC3414643
  9. Abbott, R.D., Howe, A.K. , Langevin, H.M. , Iatridis, J.C.. (2012) Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of human annulus fibrosus cells is restricted. Biochem Biophys Res Commun. 421:361-6.
  10. Caldwell, G., Howe, A.K., Nickl, C., Dostmann, W., Ballif, B., and Deming, P.. (2012) Direct modulation of the Protein Kinase A catalytic subunit α by receptor tyrosine kinases. J. Cell Biochem. 113:39-48
  11. McKenzie, A., Campbell, S.L. and Howe, A.K.. (2011) Protein Kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. PLoS ONE 6(10):e26552 (*Recommended by the Faculty of 1000 as a "Must Read")
  12. Howe, A.K.. Second messenger cross-talk in cell migration. (2011) Curr. Opin. Cell Biol. 23:554-61.
  13. Cassavaugh, J., Hale, S.A., Wellman, T.L., Howe, A.K., Wong, C., Lounsbury, K.M.. (2011) Glycogen synthase kinase 3β (GSK3β) targets hypoxia inducible factor-1α (HIF-1α) for proteasomal degradation during hypoxia. J. Cell. Biochem. 112:3882-90
  14. Langevin H.M., Bouffard N.A., Fox J.R., Palmer B.M., Wu J., Iatridis J.C., Barnes W.D., Badger, G.J., and Howe, A.K.. (2010) Fibroblast cytoskeletal remodeling contributes to connective tissue tension. J. Cell. Physiol. 226:1166-75.
  15. Langevin, H.M., Storch, K.N., Snapp, R.R., Bouffard, N.A., Badger, G.J., Howe, A.K., Taatjes, D.J.. (2010) Tissue stretch induces nuclear remodeling in connective tissue fibroblasts. Histochem Cell Biol. 133:405-15.
  16. Rivard, R.L., Birger, M., Gaston, K.J., and Howe A.K.. (2009) AKAP-independent localization of type-II protein kinase A to dynamic actin microspikes. Cell Motil Cytoskel. 66:693-709
  17. Deming, P.B., Campbell, S.L., Baldor, L.C., and Howe, A.K.. (2008) Protein Kinase A regulates 3' phosphatidylinositide dynamics during PDGF-induced membrane ruffling and chemotaxis. J. Biol. Chem. 283:35199-211.
  18. Phalen, T.J., Weirather, K., Deming, P.B., Anathy, V., Howe, A.K., van der Vliet, A., Jonsson, T., Poole, L., and Heintz, N.H.. (2006) Hyper-oxidation governs structural transitions in peroxiredoxin II oligomers that correlate with cell cycle arrest and recovery. J. Cell Biol. 175:779-789.
  19. Langevin, H.M., Bouffard, N.A., Badger, G.J., Churchill, D.L., Howe, A.K.. (2006) Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: Evidence for a mechano-transduction-based mechanism. J Cell Physiol. 207:767-774.
  20. Howe, A.K., Baldor, L.C., and Hogan, B.P. (2005) Spatial regulation of cAMP-dependent protein kinase during chemotaxis. Proc. Natl. Acad. Sci. USA 102:14320-14325.
  21. Stanley, A.C., Lounsbury, K.M., Corrow, K., Callas, P.W., Zhar, R., Howe, A.K., Ricci, M.A. (2005) Pressure elevation slows the fibroblast response to wound healing. J. Vasc. Surg. 42:546-551.
  22. Langevin, H.M., Bouffard, N.A., Badger, G.J., Iatridis, J.C., and Howe, A.K. (2005) Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo. Am. J. Physiol. Cell Physiol. 288:C747-756.
  23. Howe, A.K. (2004) Regulation of actin-based cell migration by cAMP and PKA (Review). Biochim. Biophys. Acta 1692:159-174.
  24. Goldfinger, L.E., Han, J., Kiosses, W.B., Howe, A.K., and Ginsberg, M.H.. (2003) Spatial restriction of 4-integrin phosphorylation regulates lamellipodial stability and α4β1-dependent cell migration. J. Cell. Biol. 162:731-741.
  25. Howe, A. K., Hogan, B.P., and Juliano, R.L.. (2002) Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion. J. Biol. Chem. 277: 38121-38126
  26. Howe, A.K., Aplin, A.E., and Juliano, R.L.. (2002) Anchorage-dependent ERK signaling - mechanisms and consequences. Curr. Opin. Genet. Dev. 12:30-35.
  27. Howe, A.K.. (2001) Cell adhesion regulates the interaction between Nck and p21-activated kinase. J. Biol. Chem. 276:14541-14544.
  28. Howe, A.K. and Juliano, R.L.. (2000) Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nature Cell Biol. 2:593-600.
  29. Howe, A., Aplin, A.E., Alahari, S. and Juliano, R.L.. (1998) Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10:220-231.
  30. Howe, A. and Juliano, R.L.. (1998) Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade. J. Biol. Chem. 273:27268-27274.