An applied climatologist by training, Dr. Dupigny-Giroux's research interests intersect a number of interdisciplinary fields including hydroclimatic natural hazards and climate literacy as well as the use of remote sensing and GIS (Geographic Information Systems) in the fields of spatial climate and land-surface processes. Dr. Dupigny-Giroux is also the State Climatologist for Vermont. Her work takes her across Vermont to assist colleagues in State Agencies (transportation, emergency management, agriculture, forestry and legislators) to help plan for and adapt to climate change. She is an expert in floods, droughts and severe weather and the ways in which these affect Vermont's landscape and people.

She also works extensively with K-12 teachers and students, bringing the use of satellites and understanding climate to all levels of the pre-university curriculum. She is the lead editor of Historical climate variability and impacts in North America, the first monograph to deal with the use of documentary and other ancillary records for analyzing climate variability and change.