University of Vermont

College of Medicine

Vermont Lung Center

Bio for Yvonne Janssen-Heininger, Ph.D.
Yvonne Janssen-Heininger, Ph.D.

Yvonne Janssen-Heininger, Ph.D.

Professor, Department of Pathology & Laboratory Medicine


Contact Information
E-mail: Yvonne.Janssen@uvm.edu
Office Location:
Health Science Research Facility 216A

Expertise

Protein-thiol-redox based Signaling, S-glutathionylation, Airway Epithelial Biology, Asthma, Pulmonary Fibrosis, Transcription Factors: Nuclear Factor Kappa B, death receptors: Fas, Epithelial to Mesenchymal Transition, c-Jun-N-terminal kinase, Fibrosis

Academic Interests

To provide an exciting research environment and extensive mentoring to all laboratory members to enable each of them to be maximally successful in the arena of biomedical sciences in diverse capacities.

Research Interests

To unravel the molecular basis of diverse pulmonary diseases by emphasizing the biology of epithelial cells and redox-dependent processes.

Postdoctoral Training

10/1/93 - 6/30/96 Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT

Education

1993  Ph.D.: Maastricht University, The Netherlands
In alliance with: Maastricht University Medical Center, Di-One Institute
1988  BA/MS - University of Limburg, Maastricht, The Netherlands
Major: Biological Health Sciences, Faculty of Health Sciences

Academic Appointments

2017- Present Vice-Chair for Research, Department of Pathology & Laboratory Medicine,  The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT
2008 - Present Professor, University of Vermont, Department of Pathology, Burlington, VT
1999 - Present Adjunct Professor, Department of Pulmonology University of Maastricht, Maastricht, The Netherlands
2002 - 2008 Associate Professor, University of Vermont, Department of Pathology, Burlington, VT
1997 - 2002  Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1996 - 1997 Research Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1993 - 1996  Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT

Awards and Honors

2014–2016 Elected Chair, Lung Injury Repair and Remodeling Study Section, National Institutes of Health

2010-2016  Member, National Institutes of Health, Lung Injury, Repair and Remodeling Study Section
2010  "J. Walter Juckett Scholar Award", Lake Champlain Cancer Research Organization
2002-2005  Member, National Institutes of Health, Lung Biology and Pathology Study Section
1996-1997  "Senator Proctor Research Award", American Lung Association of Vermont
1996  "JAAP Swierenga Award", Dutch College of Chest Physicians, The Netherlands
1995-1998  "Parker B. Francis Fellowship in Pulmonary Research"
1994  "Thesis Award 1992-1993" Nutrition Toxicology and Environmental Research Institute, Maastricht, The Netherlands

Publications

TGF-ß1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a JNK1-dependent manner. van der Velden JL, Wagner DE, Lahue KG, Abdalla ST, Lam YW, Weiss DJ, Janssen-Heininger YMW. Am J Physiol Lung Cell Mol Physiol. 2018 Feb 22. doi: 10.1152/ajplung.00053.2017. [Epub ahead of print] PMID: 29469614

IL-1/inhibitory ?B kinase e-induced glycolysis augment epithelial effector function and promote allergic airways disease. Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JLJ, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW. J Allergy Clin Immunol. 2017 Nov 3. pii: S0091-6749(17)31663-9. doi: 10.1016/j.jaci.2017.08.043. [Epub ahead of print] PMID: 29108965

The Duffy antigen receptor for chemokines regulates asthma pathophysiology. Chapman DG, Mougey EB, Van der Velden JL, Lahue KG, Aliyeva M, Daphtary N, George KL, Hoffman SM, Schneider RW, Tracy RP, Worthen GS, Poynter ME, Peters SP, Lima JJ, Janssen-Heininger YMW, Irvin CG. Clin Exp Allergy. 2017 Sep;47(9):1214-1222. doi: 10.1111/cea.12949. Epub 2017 Jun 9. PMID: 28471517

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME. Redox Biol. 2017 Aug;12:883-896. doi: 10.1016/j.redox.2017.04.020. Epub 2017 Apr 25. PMID: 28463821 Free PMC Article

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection. Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YMW, Kolls JK, Anathy V, Alcorn JF. Am J Pathol. 2017 Apr;187(4):851-863. doi: 10.1016/j.ajpath.2016.12.012. Epub 2017 Feb 10. PMID: 28193481 Free PMC Article

The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies. Heppner DE, Janssen-Heininger YMW, van der Vliet A. Arch Biochem Biophys. 2017 Feb 15;616:40-46. doi: 10.1016/j.abb.2017.01.008. Epub 2017 Jan 23. PMID: 28126370 Free PMC Article

I
nvolvement of c-Jun N-Terminal Kinase in TNF-a-Driven Remodeling. Eurlings IM, Reynaert NL, van de Wetering C, Aesif SW, Mercken EM, de Cabo R, van der Velden JL, Janssen-Heininger YM, Wouters EF, Dentener MA. Am J Respir Cell Mol Biol. 2017 Mar;56(3):393-401. doi: 10.1165/rcmb.2015-0195OC. PMID: 27875656 Free PMC Article

DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma. Habibovic A, Hristova M, Heppner DE, Danyal K, Ather JL, Janssen-Heininger YM, Irvin CG, Poynter ME, Lundblad LK, Dixon AE, Geiszt M, van der Vliet A. JCI Insight. 2016 Nov 3;1(18):e88811. PMID: 27812543 Free PMC Article

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. Redox Biol. 2016 Oct;9:306-319. doi: 10.1016/j.redox.2016.09.003. Epub 2016 Sep 11. PMID: 27693992 Free PMC Article

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers. van der Velden JL, Ye Y, Nolin JD, Hoffman SM, Chapman DG, Lahue KG, Abdalla S, Chen P, Liu Y, Bennett B, Khalil N, Sutherland D, Smith W, Horan G, Assaf M, Horowitz Z, Chopra R, Stevens RM, Palmisano M, Janssen-Heininger YM, Schafer PH. Clin Transl Med. 2016 Dec;5(1):36. doi: 10.1186/s40169-016-0117-2. Epub 2016 Sep 2. PMID: 27590145 Free PMC Article

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase p. McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM. JCI Insight. 2016 Jun 2;1(8). pii: e85717. PMID: 27358914 Free PMC Article

Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM. Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26. PMID: 27058114 Free PMC Article

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice. Hoffman SM, Qian X, Nolin JD, Chapman DG, Chia SB, Lahue KG, Schneider R, Ather JL, Randall MJ, McMillan DH, Jones JT, Taatjes DJ, Aliyeva M, Daphtary N, Abdalla S, Lundblad LK, Ho YS, Anathy V, Irvin CG, Wouters EF, Reynaert NL, Dixon AE, van der Vliet A, Poynter ME, Janssen-Heininger YM. Am J Respir Cell Mol Biol. 2016 Sep;55(3):377-86. doi: 10.1165/rcmb.2015-0401OC. PMID: 27035878 Free PMC Article

Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice. Hoffman SM, Nolin JD, Jones JT, Lahue KG, Chapman DG, Aliyeva M, Daphtary N, Lundblad LK, Abdalla S, Ather JL, Ho YS, Irvin CG, Anathy V, Wouters EF, Poynter ME, Janssen-Heininger YM. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S97. doi: 10.1513/AnnalsATS.201510-656MG. PMID: 27027965 Free PMC Article

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses. Hristova M, Habibovic A, Veith C, Janssen-Heininger YM, Dixon AE, Geiszt M, van der Vliet A. J Allergy Clin Immunol. 2016 May;137(5):1545-1556.e11. doi: 10.1016/j.jaci.2015.10.003. Epub 2015 Nov 17. PMID: 26597162 Free PMC Article

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness. Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V. J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4. PMID: 26435004 Free PMC Article

For a complete list of Yvonne Janssen-Heininger's publications, please visit PubMed.