University of Vermont

College of Medicine

Vermont Lung Center

Bio for Vikas Anathy, Ph.D.
Vikas Anathy, Ph.D.

Vikas Anathy, Ph.D.

Assistant Professor, Department of Pathology & Laboratory Medicine


Contact Information
E-mail: Vikas.Anathy@uvm.edu
Phone:
(802)656-4573
Office Location:
Health Science Research Facility 216

Research Interests

Endoplasmic Reticulum (ER) stress and Protein Disulfide Isomerases in Asthma.
Unfolded Protein Response in respiratory virus infection.
Redox regulation of inflammatory response and airway remodeling in asthma.
Redox regulation of fibroblast proliferation in pulmonary fibrosis

 

Postdoctoral Training

2004-2007 Postdoctoral Associate, Department of Pathology, University of Vermont College of Medicine

Education

1999-2004 PhD, Biological Sciences, Madurai Kamaraj University, Madurai, India
1994-1996 MSc, Biotechnology, University of Mysore, Mysore, India
1990-1994 BSc, Biochemistry, Botany & Zoology, University of Mysore, Mysore, India

Academic Appointments

2015-present Assistant Professor (Tenure Track), Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine
2013-2015 Assistant Professor (Research Track), Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine
2007-2013 Research Associate, Department of Pathology, University of Vermont College of Medicine

Awards and Honors

2015 UVM nominee for the Searle scholar award’s nationwide competition
2014 Asthma and Allergy Foundation of America-Sheldon C. Siegel Award
2014 American Thoracic Society Abstract Scholarship ATS-2014, San Diego
2012 American Thoracic Society Jo Rae Wright Award
2010 American Thoracic Society Travel Award ATS-2010, New Orleans
2000-2002 Senior Research Fellow, Scholarship Award and stipend from Council of Scientific and Industrial Research, India
1997-2000 Junior Research Fellow, Scholarship Award and stipend from Department of Biotechnology, India
1996-1997 Research Assistant, Scholarship Award including Salary Support from Department of Biotechnology, India

Publications

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. “Reducing protein oxidation reverses lung fibrosis.” Nat Med. 2018 Jul 9. doi: 10.1038/s41591-018-0090-y. [Epub ahead of print] PMID: 29988126

Glycolysis promotes caspase-3 activation in lipid rafts in T cells. Secinaro MA, Fortner KA, Dienz O, Logan A, Murphy MP, Anathy V, Boyson JE, Budd RC. Cell Death Dis. 2018 Jan 19;9(2):62. doi: 10.1038/s41419-017-0099-z. PMID: 29352186 Free PMC Article

IL-1/inhibitory ?B kinase e-induced glycolysis augment epithelial effector function and promote allergic airways disease. Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JLJ, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW. J Allergy Clin Immunol. 2017 Nov 3. pii: S0091-6749(17)31663-9. doi: 10.1016/j.jaci.2017.08.043. [Epub ahead of print] PMID: 29108965

Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease. Siddesha JM, Nakada EM, Mihavics BR, Hoffman SM, Rattu GK, Chamberlain N, Cahoon JM, Lahue KG, Daphtary N, Aliyeva M, Chapman DG, Desai DH, Poynter ME, Anathy V. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1243-59. doi: 10.1152/ajplung.00396.2015. Epub 2016 May 6. <?xml:namespace prefix = "o" ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>

PMID: 27154200 Free PMC Article

Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM. Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26. PMID: 27058114 Free PMC Article

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness. Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V. J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4. PMID: 26435004 Free PMC Article

Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. Kien CL, Bunn JY, Fukagawa NK, Anathy V, Matthews DE, Crain KI, Ebenstein DB, Tarleton EK, Pratley RE, Poynter ME. J Nutr Biochem. 2015 Dec;26(12):1599-606. doi: 10.1016/j.jnutbio.2015.07.014. Epub 2015 Aug 1. PMID: 26324406 Free PMC Article

The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor ?B family proteins. Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM. Free Radic Biol Med. 2014 Aug;73:143-53. doi: 10.1016/j.freeradbiomed.2014.04.028. Epub 2014 May 9. PMID: 24816292 Free PMC Article

Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis. Hoffman SM, Tully JE, Nolin JD, Lahue KG, Goldman DH, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Poynter ME, Anathy V. Respir Res. 2013 Dec 24;14:141. doi: 10.1186/1465-9921-14-141. PMID: 24364984 Free PMC Article

Emerging mechanisms of glutathione-dependent chemistry in biology and disease. Janssen-Heininger YM, Nolin JD, Hoffman SM, van der Velden JL, Tully JE, Lahue KG, Abdalla ST, Chapman DG, Reynaert NL, van der Vliet A, Anathy V. J Cell Biochem. 2013 Sep;114(9):1962-8. doi: 10.1002/jcb.24551. Review. PMID: 23554102 Free PMC Article

Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease. Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, Budd RC, Reynaert NL, Anathy V. Ann N Y Acad Sci. 2010 Aug;1203:23-8. doi: 10.1111/j.1749-6632.2010.05553.x. Review. PMID: 20716279 Free PMC Article

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control. Janssen-Heininger YM, Poynter ME, Aesif SW, Pantano C, Ather JL, Reynaert NL, Ckless K, Anathy V, van der Velden J, Irvin CG, van der Vliet A. Proc Am Thorac Soc. 2009 May 1;6(3):249-55. doi: 10.1513/pats.200806-054RM. Review. PMID: 19387025 Free PMC Article

To view all of Vikas Anathy's publications, please visit PubMed.