CREAM cows at the farm

Please contact me for additional information. 

The Barlow Lab conducts research on dairy cattle health and disease. We conduct laboratory and on-farm experiments ranging across molecular, cellular, and population levels. Examples of the techniques we use include: basic microbiology, mammalian cell culture models, mathematical epidemiologic models, immunologic and molecular diagnostics, and nucleic acid sequence analysis.

Research:

I study host-pathogen interactions and the impact of infectious disease control interventions (e.g. vaccination and antimicrobial use) on cattle health. My work is motivated by practical concerns of dairy cattle health on food production, and encompasses epidemiology, molecular genetics, microbiology and immunology. I am interested in economically significant diseases of dairy cattle that affect productivity and ultimately human health and well-being through food availability. I am also interested in epidemiology and host specificity of infectious diseases at the human-animal interface. Broadly, my research interests involve the intersection between epidemiologic and molecular genetic approaches to understand the population biology of host-pathogen relationships.

Lab Publications

Reksen, O., Gröhn, Y., Mitchell, R.M., Barlow, J.W., and Schukken, Y.H. 2012. Transmission dynamics of intramammary infections with Coagulase negative Staphylococci. Journal of Dairy Science.

Nene, V., Svitek, N., Toye, P., Golde, W., Barlow, J., Buus, S., and Nielsen, M. 2012. Designing bovine T cell vaccines via reverse immunology. Ticks and Tick-borne Diseases

Barlow, J. 2011. Mastitis Therapy and Antimicrobial Susceptibility: a multispecies review with a focus on antibiotic treatment of mastitis in dairy cattle. Journal of Mammary Gland Biology and Neoplasia, 16:383-407. Impact factor 5.446

Barlow, J.W., White, L.J., Zadoks, R.N., and Schukken, Y.H. 2009.  A mathematical model demonstrating indirect and overall effects of lactation therapy targeting subclinical mastitis in dairy herds. Preventive Veterinary Medicine, 90:31-42. Impact factor 1.704

Schukken, Y.H., Bar, D., Gröhn, Y.T., Barlow, J.W., Quesnell, R.R., Zadoks, R.N. 2008. Milk quality improvement and mastitis control on dairy farms: The case of persistent infections and repeated clinical cases. Magyar Állatorvosok Lapja [Hungarian Veterinary Journal] 130:591-606.

Barlow, J.W.  Rauch, B., Welcome, F., Kim, S.G., Dubovi, E., and Schukken, Y.H. 2007. Association between Coxiella burnetii shedding in milk and subclinical mastitis in dairy cattle. Veterinary Research 39:23-31. Impact factor 4.125

Fan, W., Plaut, K., Bramley, A.J., Barlow, J.W., Mischler, S.A., Kerr D.E. 2004. Persistency of adenoviral-mediated lysostaphin expression in goat mammary glands. Journal of Dairy Science 87: 602-608. Impact factor 2.361

Tikofsky, L., Barlow, J.W., Santisteban, C., and Schukken, Y.H. 2003. A comparison of antimicrobial susceptibility patterns for Staphylococcus aureus in organic and conventional dairy herds.  Microbial Drug Resistance 9 (suppl 1) S39-S45. Impact factor 1.543

Barlow, J., Yandell, D., Weaver, D. Casey, T. and Plaut, K. 2003. Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors. Breast Cancer Research and Treatment 79: 149-159. Impact factor 4.453

Fan, W., Plaut, K., Bramley, A.J., Barlow, J.W., and Kerr, D.E. 2002. Adenoviral-mediated transfer of a lysostaphin gene in the goat mammary gland. J. Dairy Sci. 85:1709-1716. Impact factor 2.361

McDougall, S., Murdough, P., Pankey, J.W., Delaney, C., Barlow, J., and Scruton, D.  2001. Relationships among somatic cell count, California Mastitis Test, impedance and bacteriological status of milk in goats and sheep in early lactation.  Small Ruminant Research 40:245-254. Impact factor 0.966

Barlow, J., Casey, T., Chiu, J., and Plaut, K. 1997.  Estrogen affects development of alveolar structures in whole-organ culture of mouse mammary glands.  Biochem. Biophys. Res. Commun. 232: 340-344. Impact factor 2.749

John working in his lab

If you wish to see a copy of my CV or get a complete listing of my publications, please contact me directly.

Resources

Lab Management Resources

General Barlow Lab Sharepoint (Net ID/password protected)

Cattle MHC Project Sharepoint (Net ID/password protected)

HR Time Approval in PeopleSoft (Net ID/password protected)


Tools

https://github.com/MitalGitHub/IPD_MHC
This Ruby script was developed by Mital Pandya to facilitate access to and manipulation of data contained within the bovine Major Histocompatibility Complex Immunopolymorphism Database (MHC-IPD). The Ruby script allows the user to sort the database based on breed, serological specificity or reference, and extract the FASTA file of the alleles sorted. Any questions about the script should be sent to mpandya@uvm.edu.

Teaching

My Courses

ASCI 191 Farm Animal Production Systems – will make permanent with name change of asci 113 after offering next semester
ASCI 177 Animal Plagues and Global Health;
ASCI 322 One Health: Zoonoses;
ASCI 298 Molecular and Mathematical Epidemiology of Infectious Disease;
ASCI 298 One Health: Antimicrobial Resistance;
ASCI 303 Research Proposal Writing.

Contact Information

John Barlow, D.V.M., Ph.D.
john.barlow@uvm.edu
Associate Professor

Department of Animal and Veterinary Sciences
University of Vermont
221 Terrill, 570 Main Street
Burlington, VT  05405-0148
http://asci.uvm.edu

Office: (802)-656-1395
Lab: (802)-656-2209
Fax: (802)-656-8196