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Wolfgang Dostmann

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University of Vermont
College of Medicine
Department of Pharmacology
149 Beaumont Avenue
HSRF 340
Burlington, VT 05405
USA

Phone: (802) 656-5712
Fax: (802) 656-4523

Recent Publications


Direct modulation of the protein kinase a catalytic subunit α by growth factor receptor tyrosine kinases.

Caldwell GB, Howe AK, Nickl CK, Dostmann WR, Ballif BA, Deming PB.
J Cell Biochem. 2012 Jan;113(1):39-48. doi: 10.1002/jcb.23325.



Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication.

Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL Jr, Kornev AP, Taylor SS, Dostmann WR.
Structure. 2011 Sep 7;19(9):1317-27.



Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.

Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C.
Basic Res Cardiol. 2011 Nov;106(6):1023-39. Epub 2011 Oct 20.



Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors

Batchelor AM, Bartus K, Reynell C, Constantinou S, Halvey EJ, Held KF, Dostmann WR, Vernon J, Garthwaite J.
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22060-5. Epub 2010 Dec 6.



(D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha

Nickl CK, Raidas SK, Zhao H, Sausbier M, Ruth P, Tegge W, Brayden JE, Dostmann WR.
Biochim Biophys Acta. 2010 Mar;1804(3):524-32. Epub 2009 Dec 16.



cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake

Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD.
Mol Brain. 2009 Aug 5;2(1):26.



Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry

Pinkse MW, Rijkers DT, Dostmann WR, Heck AJ
J Biol Chem. 2009 Jun 12;284(24):16354-68. Epub 2009 Apr 15


Science
Direct
Selective inhibitors of cyclic nucleotide dependent protein kinases

Nickl, CK, Dostmann WRG
Handbook of Cell Signal. Academic Press, pp1479-1488, (Review), (2009)



Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors.

Nausch LW, Ledoux J, Bonev AD, Nelson MT, Dostmann WR
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):365-70. Epub 2007 Dec 28.