Department of Molecular Physiology & Biophysics
University of Vermont College of Medicine
Burlington, Vermont 05405-0068
B.S. - 1973 - Electrical Engineering, Rutgers University, New Brunswick, NJ
Ph.D. - 1978 - Physiology and Biophysics, University of Vermont, Burlington, VT
Postdoctorate - 1978 - Biophysics, Aarhus University, Denmark - 1978-1983 - UMass Medical School
1975 - 1978: Graduate Student, Physiology & Biophysics, Univ. of Vermont; Advisor: Dr. W. Halpern
1978 - 1983: Postdoctoral Fellow/Instructor, Physiology & Biophysics, UMass Mentor: Dr. F. Fay
1983 - 1989: Assistant Professor, Physiology & Biophysics, University of Vermont
1989 - 1991: Associate Professor, Physiology & Biophysics, University of Vermont
1991-1995: Professor, Molecular Physiology & Biophysics, University of Vermont
1995-Present: Professor and Chairman, Molecular Physiology & Biophysics, University of Vermont
1988-93: American Heart Association Established Investigatorship
1989: Encyclopedia Britannica, author: "Smooth Muscle: Muscles and Muscle Systems"
1999: University of Vermont Scholar
1999: Member, Vermont Academy of Science and Engineering
2001: U.S. Rep. for the NHLBI/US- Russia Symposium on Basic Research in CV and Pulmonary Diseases.
2001: American Heart Association Fellow
American Heart Association - Basic Science Member
American Physiological Society - Regular Member
Biophysical Society - Senior Member
American Association for the Advancement of Science - Regular Member
Author or co-author of more than 75 peer-reviewed papers in Science, Proceedings of National Academy of Science USA, Circulation Research, Journal of Cell Biology, Biophysics Journal, and other journals.
Editorial Work: Editorial Board (Past & Present): J Vascular Res, Am J Physiol (Cell), J Muscle Res & Cell Motil, Biophys J
Manuscript Review: Circ Res, PNAS, Nature, J Clin Inv, J Physiol (Lond), Science, J Mol Biol, JCB, J Cell Sci
Molecular Motors and Heart Disease: The Warshaw Molecular Motors Group focuses on the structure and function of myosin, a molecular motor associated with biological movement ranging from muscle contraction to intracellular vesicular transport. Researchers still do not understand how myosin converts the energy from ATP hydrolysis into mechanical work as the molecular motor moves along its actin track. Our approach is a comparative one by studying myosin from various tissue sources that differ substantially in both their structure and functional capacities. Additional insight can be obtained from genetically mutated myosin and actin, which lead to inherited forms of human heart failure. We use the power of molecular biophysics and single molecule techniques to characterize the molecular performance of the actomyosin motor.