DR. PAULA B. TRACY (2003) pdf

Dr. Tracy
Address:
Interim Chair of Biochemistry
University of Vermont, College of Medicine
89 Beaumont Avenue
Given Building, Room C401
Burlington, VT 05405
Email: Paula.Tracy@uvm.edu

Telephone:
(802) 656-2220

Education:
B.A. William Smith College, Geneva, NY, 1972. Biology
Ph.D. Syracuse University, Syracuse, NY, 1978. Biochemistry

Professional Experience:
1977-1978 Post-Doctoral Fellow, Syracuse University, Syracuse, NY
1978-1980 Post-Doctoral Fellow, Mayo Clinic, Rochester, MN
1980-1983 Blood Banking and Hemostasis Trainee, Mayo Clinic, Rochester, MN
1983-1984 Assistant Professor of Pathology, University of Rochester, School of Medicine and Dentistry, Rochester, NY
1984-1989 Research Assistant Professor of Medicine and Biochemistry, UVM, Burlington, VT
1989-1991 Research Associate Professor of Medicine and Biochemistry, UVM, Burlington, VT
1991-1997 Associate Professor of Biochemistry and Medicine, UVM, Burlington, VT
1997-pres Professor of Biochemistry and Medicine, UVM, Burlington, VT
2005-pres Interim Chairperson, Biochemistry Department, UVM, Burlington, VT

Other Experience and Professional Memberships:
1989-1993 Member, NHLBI Hematology I Study Section
1997-2001 Member, NHLBI Hematology I Study Section
1990-1999 Associate Editor, Arteriosclerosis, Thrombosis and Vascular Biology
1999-pres Member, Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology
1994-1996 Vice-Chair/Chair, Gordon Conference on Hemostasis
1995-1999 Member, Editorial Board, Blood
2005 Co-organizer, FASEB Summer Research Conference, Proteases in Hemostasis and Vascular Biology

Honors and Awards:
1976 Alexander Gourevitch Memorial Award for Meritorious Achievements as a Graduate Student in Research, Syracuse, NY
1982 Edward C. Kendall Award for Meritorious Research, Mayo Clinic
1987-1992 Established Investigator, American Heart Association
2001 ATVB Special Recognition Award
2004 University Scholar, University of Vermont
2005 American Medical Women's Assn, "Gender Equity Award", UVM Chapter

Selected Publications [Since 1996]:
8. Bajzar L, Nesheim ME and Tracy PB: The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent (1996). Blood 88:2093-2100.
9. Bajzar L, Kalafatis M, Simioni P and Tracy PB: An antifibrinolytic mechanism describing the prothrombotic effect associated with factor V Leiden (1996). J. Biol. Chem. 271:22949-22952.
10. Bouchard BA, Shatos MA and Tracy PB: Human brain pericytes differentially regulate the expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood coagulation (1997). Arterioscl. Thromb. Vasc. Biol. 17:1-9.
11. Bouchard BA, Catcher CS, Trash BR, Adida C and Tracy PB: Effector cell protease receptor-1 (EPR-1), a platelet activation-dependent membrane protein regulates prothrombinase-catalyzed thrombin generation (1997). J. Biol. Chem. 272:9244-9251.
12. Bajzar L, Nesheim ME, and Tracy PB: Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of TAFI (1998). J. Biol. Chem. 273:2792-2798.
13. Camire RM, Kalafatis M, Simioni P, Girolami A, and Tracy PB: Platelet-derived factor Va and factor VaLeiden cofactor activity are sustained on the surface of activated platelets despite the presence of activated protein C (1998). Blood 91:2818-2829.
14. Camire RM, Kalafatis M and Tracy PB: Proteolysis of factor V by cathepsin G and elastase indicates that cleavage at Arg1545 optimizes cofactor function by facilitating factor Xa binding (1998). Biochemistry 37:11896-11906.
15. Camire RM, Pollak ES, Kaushansky K and Tracy PB: Secretable human platelet-derived factor V originates from the plasma pool (1998). Blood 92:3035-3041.
16. Tracy PB, Camire RM, Pollak ES, Kaushansky K: Where does platelet factor V originate? (Response to letter). (1999) Blood 93:3152.
17. Hayes KL, and Tracy PB: The platelet high affinity binding site for thrombin mimics hirudin, modulates thrombin-induced platelet activation and is distinct from the glycoprotein Ib-IX-V complex (1999). J. Biol. Chem., 244:972-980.
18. Bouchard BA and Tracy PB: Platelets, leukocytes and coagulation (Review) (2001). Curr. Opin. Hematol. 8:263-269.
19. Bouchard BA, Silveira JR and Tracy PB: On the role of EPR-1 or an EPR-1-like molecule in regulating factor Xa incorporation into Prothrombinase (2001). Thromb Haemost. 86:1133-1134.
20. Bouchard BA and Tracy PB: Platelet regulation of thrombin generation in cardiovascular disease (Review) (2001). Ital. Heart J. 2:819-823.
21. Silveira JR, Kalafatis M and Tracy PB: Carbohydrate moieties on the procofactor factor V, but not the derived cofactor factor Va, regulate its inactivation by activated protein C (2002). Biochemistry 41:1672-1680.
22. Bouchard BA, Butenas S, Mann KG and Tracy PB: Interactions between platelets and the coagulation system. In: Platelets. Michelson AD, ed. Academic Press, San Diego, CA, pp. 229-253, 2002.
23. Gould WR, Silveira JR and Tracy PB: Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va (2004). J. Biol. Chem. 279(4):2383-2393.
24. Gould WR, Simioni P, Silveira JR, Luni S and Tracy PB: Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor. (2005) J. Thromb. Haemost:3:45-456.
25. Bouchard BA, Williams JL, Meisler NT, Long MW and Tracy PB: Endocytosis of plasma-derived factor V by megakaryocytes occurs via a clathrin-dependent, receptor-mediated event (2005) J. Thromb. Haemost: 3:541-551.
26. Bouchard BA, Butenas S, Mann KG and Tracy PB: Interactions between platelets and the coagulation system. In: Platelets, Michelson AD (Ed), Academic Press, San Diego, CA, in press.