Understanding how the body works down to the tiniest parts within its cells often yields big insights. University of Vermont College of Medicine graduate student Rui Yang’s research sits square at the molecular end of the spectrum, but is on its way to opening new doors for further research into potential therapies for inflammatory diseases like rheumatoid arthritis.

By studying how molecules within cells from mice interact to produce responses, Yang has discovered a new pathway that regulates a group of immune cells called CD4 cells. For the first time, the mitochondria in these CD4 cells have been shown to be affected by a molecule known as Interleukin 6, a known trigger for inflammation. Making this connection means a new pathway ripe for further study as a potential drug target.

Yang, who is studying for his Ph.D. in cellular, molecular and biomedical sciences, recently published his research in eLIFE. He and his mentor Mercedes Rincon, Ph.D., professor of medicine, have also received a Careers in Immunology Fellowship from the American Association of Immunologists (AAI). Rincon was one of 48 AAI members selected to receive one of these fellowships, which provide independent research scientists with fellowships supporting one year of salary for a predoctoral or postdoctoral trainee in their labs. Selection of recipients is based on a combination of potential of the trainee, merit of the project, quality of the training environment, and financial need.