University of Vermont

University Communications

JIM O. VIGOREAUX

Professor and Chair
Biology
Arts & Sciences
Phone:(802)656-4627
Email Address:Jim.Vigoreaux@uvm.edu
Public Relations:Josh Brown (802)656-3039 joshua.e.brown@uvm.edu
Specialty:muscle function and development; insect flight; function of novel muscle proteins; Drosophila; functional genomics; proteomics
Biography:Vigoreaux studies various aspects of muscle structure, function, and development in the fruit fly Drosophila melanogaster and in cardiac muscle of humans (diabetic cardiomyopathies) and rats (hypertrophy and heart failure). Like many other organisms, Drosophila has different muscle types that perform distinct functions. These muscles exhibit morphological as well as physiological differences. The main theme of his studies is to understand how specific muscle proteins are assembled to form structures specialized for distinct functions and how these molecular interactions define the mechanical properties of muscles. His research relies on a combination of classical and molecular genetics and proteomics approaches to protein function. Among Vigoreaux's publications are several review articles such as "The muscle Z band: Lessons in stress management" (Journal of Muscle Research and Cell Motility, 1994) and "Genetics of the Drosophila flight muscle myofibril: a window into the biology of complex systems" (BioEssays 2001). He is currently editing a book on muscle proteins and writing a comprehensive review on insect muscle development. His research is supported by NSF and NIH. He teaches Cell Biology and a course on the history and method of science.