The primary objective of this course is to provide students with a theoretical overview and practical experience of techniques that can be applied for the investigation of pathological changes in cells and tissues. The course includes comprehensive classroom and laboratory sessions on microscopy techniques (including light, contrast, fluorescence, confocal, electron, atomic force, laser capture microdissection and laser scanning cytometry); histochemical staining techniques (including Papanicolaou staining of cytological cell samples and hematoxylin and eosin [H&E] staining of fixed tissue specimens); immunohistochemistry; and in situ hybridization. The course also covers the principles of anatomic/surgical and clinical pathology by way of classes on: cytopathology, histopathology, hematopathology, medical microbiology, and molecular pathology, supplemented by tours and technical demonstrations in associated FAHC laboratories.

This course combines lecture and discussion formats with laboratory practical sessions. The middle two weeks of the course are especially intensive. Students should expect to spend 6-8 hours a week on coursework outside of class. Pre-reading assignments will include a series of journal articles. Students are also required to complete an online tutorial on the Protection of Human Subjects in Research prior to the course. All materials for the course will be provided.

Grades will be based on attendance and participation; journal club presentations; presentation of an unknown pathology case assignment together with an extended essay; a multi-choice type exam.