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8th International Symposium on VIP, PACAP and Related Peptides
September 3 - 8, 2007

Monday, September 3, 2007

06:30 - 08:30 Welcome Reception and Registration ( Burlington Sheraton)

Tuesday, September 4, 2007

07:30 - 08:30 Breakfast
09:00 - 11:30 Departure for Manchester/Equinox Resort and Spa
12:00 - 01:00 Lunch
01:00 - 01:20 Registration (Equinox Resort and Spa)
01:20 - 01:30 Welcome

01:30 - 02:00
SL1: Symposium Opening Lecture
Roles of PACAP and VIP in the mammalian circadian clock.
Jan Fahrenkrug
Bispebjerg Hospital , University of Copenhagen, Copenhagen NV, Denmark

Session 1: VIP and PACAP peptides in peripheral nervous system physiology.
Session Chairs: Rodney Parsons ( University of Vermont )
Margaret Vizzard ( University of Vermont )

02:00 - 02:30
SL2. Role of VIP and PACAP in the neural control of lower urinary tract function.
William C. de Groat
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

02:30 - 02:50
O1. Release of endogenous PACAP increases guinea pig cardiac neuron excitability.
John Tompkins
University of Vermont College of Medicine, Burlington, VT, USA

02:50 - 03:10
O2. PACAP induces long-lasting enhancement of synaptic transmission in ganglionic neurons.
Phyllis Pugh
University of Toledo College of Medicine, Toledo, OH, USA

03:10 - 03:30
O3. Vasoactive intestinal polypeptide knockout (VIP-/-) mice exhibit altered bladder function and somatic sensitivity with cyclophosphamide (CYP)-induced cystitis.
Margaret Vizzard
University of Vermont College of Medicine, Burlington, VT, USA

03:30 - 03:50
O4. Pre- and postsynaptic control of spinal and supraspinal glutamatergic neurotransmission by PACAP during neuropathic pain.
Eberhard Weihe Philipps
University of Marburg Medical Center, Marburg, Germany

03:50 - 04:10 Break

Session 2: Neurotrophic functions of PACAP peptides in neurodevelopment.
Session Chairs: Marc Laburthe (INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon)
David Vaudry (INSERM U413, University of Rouen )

04:10 - 04:40
SL3. Neurotrophic effects of PACAP in the cerebellar cortex.
David Vaudry
Unité INSERM U413, University of Rouen, Mont-Saint-Aignan, France

04:40 - 05:00
O5. Granule cell neuron survival is deficient in PAC1-/- mutant cerebellum.
Emanuel DiCicco-Bloom
UMDNJ, Pistcataway, NJ, USA

05:00 - 05:20 O6. Effect of PACAP on granule cell migration in the developing cerebellum.
Ludovic Galas
Unité INSERM U413, University of Rouen, Mont-Saint-Aignan, France

05:20 - 05:40 O7. BAX gene suppression by RNA interference promotes survival of cerebellar neuronal allografts through blockade of caspase-3 cleavage.
Bruno Gonzalez
INSERM AVENIR, European Institute for Peptide Research, Rouen, France

05:40 - 06:00 O8. The role of PACAP in astroglial differentiation in vivo and in vitro.
Jun Watanabe
Showa University School of Medicine, Tokyo, Japan

07:00 - 08:30 Dinner

Wednesday, September 5, 2007

07:30 - 08:30 Breakfast/Poster Session I Assembly and Preview in Manchester Room

Session 3: PACAP /VIP-mediated protection of central neurons after injury.
Session Chairs: Richard Zigmond ( Case Western Reserve University )
Emanuel DiCicco-Bloom ( Rutgers University )

08:30 - 09:00 SL4. Functional significance of PACAP on neuroprotection and neurodevelopment.
Seiji Shioda
Showa University School of Medicine, Tokyo , Japan

09:00 - 09:20 O9. Expression of VIP is induced in reactive astrocytes after traumatic brain injury.
Aviva Symes
Uniformed Services University of the Health Sciences, Bethesda , MD, USA

09:20 - 09:40 O10. PACAP38 reduces cytokine-induced ROS production and apoptosis in the olfactory epithelium by a PAC1 receptor-mediated mechanism.
Mary Lucero University of Utah , Salt Lake City, UT, USA

09:40 - 10:00 O11. Neuroprotective mechanism of PACAP associated with IL-6 signaling.
Tomoya Nakamachi
Showa University School of Medicine, Tokyo, Japan

10:00 - 10:20 Break

Session 4: VIP/PACAP related-peptide expression and function in endocrine and gastrointestinal systems.
Session Chairs: Joseph Pisegna (UCLA)
Atsuro Miyata ( Kagoshima University )

10:20 - 10:50 SL5. The obesity epidemic: is the problem appetite or the efficient human eating machine?
M. Michael Wolfe
Boston University Medical Center, Boston, MA

10:50 - 11:10 O12. PAC1 deficient mice have increases in basal gastric acid output, an effect mediated by changes in gastric morphology.
Yuxin Lu
UCLA School of Medicine, Veterans Administration GLAHS, Los Angeles, CA, USA

11:10 - 11:30 O13. Regulation of PACAP gene expression by gonadotrophin-releasing hormone in pituitary gonadotrophs.
Lisa Halvorsen
University of Texas Southwestern Medical Center, Dallas, TX , USA

11:30 - 11:50 O14. Characterization of the testis-specific promoter region in human pituitary adenlate cyclase activating polypeptide (PACAP) gene.
Aiko Tominaga
Kagoshima University, Kagoshima, Japan

11:50 - 12:10 O15. PACAPergic mechanisms influencing fear and anxiety behaviors: role of the central nucleus of the amygdala.
Gabor Legradi
University of South Florida College of Medicine, Tampa , FL , USA

12:15 - 01:30 Lunch

Session 5: PAC1 receptors, signaling and gene activation.
Session Chairs: Eve Lutz ( University of Strathclyde )
Bruno Gonzalez (INSERM AVENIR, University of Rouen )

01:30 - 02:00 SL6. Sand flies, maxadilan and the PAC1 receptor.
Ethan Lerner
Harvard Medical School, Charlestown, MA, USA

02:00 - 02:20 O16. Neurodifferentiation of human neuroblastoma SH-SY5Y cells by PACAP38 and LIF.
Eve Marie Lutz
University of Strathclyde, Glasgow, United Kingdom

02:20 - 02:40 O17. Serpin B1A controls the antiapoptotic effects of PACAP and NGF in PC12 cells.
Aurelia Ravni
Unité INSERM U413, University of Rouen, Mont-Saint-Aignan, France

02:40 - 03:00 O18. PACAP signaling alters gene expression in ciliary ganglion neurons.
Joseph Margiotta
University of Toledo Health Sciences, Toledo, OH, USA

03:00 - 03:20 O19. Selenoprotein T is a novel target for PACAP signaling discovered via functional coupled transcriptome array and gene silencing.
Hafida Ghzili
Unité INSERM U413, University of Rouen, Mont-Saint-Aignan, France

06:30 - 07:00 AL1. Akira Arimura Young Investigator Award
Secretin: a potential neurosecretory factor regulating body water homeostasis.
Billy K. C. Chow
Hong Kong University, Hong Kong, China

07:00 - 08:30 Dinner

08:30 - 10:30 Poster Session I - Manchester Room

Thursday, September 6, 2007

07:30 - 08:30 Breakfast/Poster Session II Assembly and Preview

Session 6: VIP, PACAP and related peptide receptors: structure and pharmacology.
Session Chairs: Hubert Vaudry (INSERM U413, University of Rouen)
Terry Moody (NCI)

08:30 - 09:00 SL7. Receptors for VIP and PACAP: state of the art and perspectives.
Marc Laburthe
INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon, Paris, France

09:00 - 09:20 O20. Mapping the oligomerization interface and establishing function of secretin receptor homo-oligomers.
Kaleeckal Harikumar
Mayo Clinic, Scottsdale , AZ , USA

09:20 - 09:40 O21. Development of PACAP analogs with high activity and improved metabolic stability.
Steve Bourgault
INRS - Institut Armand-Frappier, Pointe-Claire, Canada

09:40 - 10:10 SL8. Pharmacology of vasoactive intestinal peptide (VIP) and receptor cellular signaling in pancreatic acinar cells.
Robert Jensen
NIDDK/NIH, Bethesda, MD, USA

10:10 - 10:30 Break

Session 7: Physiological insights from VIP/PACAPergic system knockout animals.
Session Chairs: James Waschek (UCLA)
Akemichi Baba ( Osaka University )

10:30 - 11:00 SL9. PACAP gene knockout mouse: trouble in the hypothalamus?
Nancy Sherwood
University of Victoria , British Columbia , Canada

11:00 - 11:20 O22. Evidence that the PACAP gene contributes to the risk of schizophrenia.
Hitoshi Hashimoto
Osaka University , Osaka , Japan

11:20 - 11:40 O23. Characterization of the VPAC1 null mouse.
Sue O’Dorisio
University of Iowa , Iowa City , IA , USA

11:40 - 12:00 O24. Perception of sensory modality in mice lacking PAC1 receptor performing on memory tasks.
Nobuyoshi, Hagino
Tulane University, Belle Chasse, LA, USA

12:00 - 12:20 O25. Blunted glucose response to stress in VPAC1 -/- mice.
Damon Shutt
University of Iowa , Iowa City , IA , USA

12:20 - 01:30 Lunch

Session 8: VIP and PACAP peptides in clinical therapeutics.
Session Chairs: Illana Gozes ( Tel Aviv University )
Douglas Brenneman (Johnson & Johnson)

01:30 - 02:00 SL10. VIP drug discovery and development: focusing on the neurotprotective drug candidate NAP.
Illana Gozes
Tel Aviv University, Tel Aviv, Israel

02:00 - 02:20 O26. Human VIP-alpha: a novel long-acting biocompatible, biodegradable and safe disease modifying nanomedicine for rheumatoid arthritis.
Israel Rubinstein
University of Illinois at Chicago, Chicago , IL , USA

02:20 - 02:40 O27. VIP as an essential modulator of the pulmonary circulation.
Sami I. Said
State University of New York at Stony Brook, Stony Brook, NY, USA

02:40 - 03:00 O28. Function of pulmonary PAC1 receptor in a murine model of allergic asthma.
Hans-Dieter Lauenstein
Fraunhofer ITEM, Hannover Medical School , Hannover , Germany

03:00 - 03:20 O29. Functional liposomes as retard formulation for vasoactive intestinal peptide.
Wilhelm Mosgoeller
Medical University of Vienna , Vienna , Austria

03:20 - 03:40 O30. PACAP prevents toxicity induced by cisplatin in primate and rat neurons but not ovarian cells.
Anthony Falluel-Morel
Unité INSERM U413, University of Rouen, Mont-Saint-Aignan , France

06:30 - 07:00 AL2. Viktor Mutt Award Lecture GEP peptides powerfully influence appetite - an ongoing story.
Stephen Bloom
Imperial College , London , United Kingdom

07:00 - 08:30 Banquet Dinner

08:30 - 10:30 Poster Session II - Manchester Room

Friday, September 7, 2007

07:30 - 09:00 Breakfast and departure preparation

Session 9: G protein-coupled VIP/PACAP receptor signaling and interactive pathways.
Session Chairs: Lee Eiden (NIMH)
Eberhard Weihe (Philipps-University of Marburg )

09:00 - 09:30 SL11. PACAP signaling: a paradigm for homeostatic response to stress through combinatorial activation of multiple pathways.
Lee Eiden
NIMH/NIH, Bethesda , MD , USA

09:30 - 09:50 O31. Combinatorial regulation of Ier3 (PACAP-regulated gene I) transcription and ERK activation by cAMP and calcium.
Matthew Gerdin
NIMH/NIH, Bethesda , MD , USA

09:50 - 10:10 O32. A novel cAMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation.
Douglas Andres
University of Kentucky , Lexington , KY , USA

10:10 - 10:30 O33. The bovine PAC1HOP receptor: insights into PACAP signaling through calcium in neuronal cell function.
Tomaris Mustafa
NIMH/NIH, Bethesda, MD, USA

10:30 - 10:50 O34. PACAP receptor amplification of long-term potentiation at CA3 - CA1 hippocampal synapses.
John MacDonald
University of Toronto , Toronto , Canada

10:50 - 11:20 SL12. Special Symposium Lecture VIP & related peptides: The long road from discovery to drug development.
Sami I. Said
State University of New York at Stony Brook, Stony Brook, NY, USA

11:20 - 11:30 Closing remarks

11:30 Preparation and Departure for Shelburne Museum/Burlington, VT

Saturday, September 8, 2007

Neural stem cells and therapeutics: current strategies and developments Davis Auditorium - Fletcher Allen Health Care/University of Vermont College of Medicine

08:30 - 09:00 Coffee and continental breakfast/Davis Auditorium

09:00 - 10:00 Stem cell biology and regenerative neuroscience
Jack A. Kessler
Boshes Professor and Chairman, Department of Neurology Director, Feinberg Neuroscience Institute Northwestern University School of Medicine

10:00 - 11:00 TBA
Jeffrey D. Macklis
Director, Massachusetts General Hospital - Harvard Medical School Center for Nervous System Repair Department of Neurosurgery and Neurology

11:00 - 12:00 Finding Therapeutics for Neurological Diseases in Academic Settings
Lee L. Rubin
Harvard University Director of Translational Research, Harvard University Stem Cell Institute

12:00 Lunch - Fleming Art Museum/University of Vermont