8th International Symposium on VIP, PACAP and Related Peptides
Monday, September 3, 2007
06:30 - 08:30 Welcome Reception and Registration ( Burlington Sheraton)
Tuesday, September 4, 2007
07:30 - 08:30 Breakfast
01:30 - 02:00
Session 1: VIP and PACAP peptides in peripheral nervous system physiology.
02:00 - 02:30
02:30 - 02:50
02:50 - 03:10
03:10 - 03:30
03:30 - 03:50
03:50 - 04:10 Break
Session 2: Neurotrophic functions of PACAP peptides in neurodevelopment.
04:10 - 04:40
04:40 - 05:00
05:00 - 05:20 O6. Effect of PACAP on granule cell migration in the developing cerebellum.
05:20 - 05:40 O7. BAX gene suppression by RNA interference promotes survival of cerebellar neuronal allografts through blockade of caspase-3 cleavage.
05:40 - 06:00 O8. The role of PACAP in astroglial differentiation in vivo and in vitro.
07:00 - 08:30 Dinner
Wednesday, September 5, 2007
07:30 - 08:30 Breakfast/Poster Session I Assembly and Preview in Manchester Room
Session 3: PACAP /VIP-mediated protection of central neurons after injury.
08:30 - 09:00 SL4. Functional significance of PACAP on neuroprotection and neurodevelopment.
09:00 - 09:20 O9. Expression of VIP is induced in reactive astrocytes after traumatic brain injury.
09:20 - 09:40 O10. PACAP38 reduces cytokine-induced ROS production and apoptosis in the olfactory epithelium by a PAC1 receptor-mediated mechanism.
09:40 - 10:00 O11. Neuroprotective mechanism of PACAP associated with IL-6 signaling.
10:00 - 10:20 Break
Session 4: VIP/PACAP related-peptide expression and function in endocrine and gastrointestinal systems.
10:20 - 10:50 SL5. The obesity epidemic: is the problem appetite or the efficient human eating machine?
10:50 - 11:10 O12. PAC1 deficient mice have increases in basal gastric acid output, an effect mediated by changes in gastric morphology.
11:10 - 11:30 O13. Regulation of PACAP gene expression by gonadotrophin-releasing hormone in pituitary gonadotrophs.
11:30 - 11:50 O14. Characterization of the testis-specific promoter region in human pituitary adenlate cyclase activating polypeptide (PACAP) gene.
11:50 - 12:10 O15. PACAPergic mechanisms influencing fear and anxiety behaviors: role of the central nucleus of the amygdala.
12:15 - 01:30 Lunch
Session 5: PAC1 receptors, signaling and gene activation.
01:30 - 02:00 SL6. Sand flies, maxadilan and the PAC1 receptor.
02:00 - 02:20 O16. Neurodifferentiation of human neuroblastoma SH-SY5Y cells by PACAP38 and LIF.
02:20 - 02:40 O17. Serpin B1A controls the antiapoptotic effects of PACAP and NGF in PC12 cells.
02:40 - 03:00 O18. PACAP signaling alters gene expression in ciliary ganglion neurons.
03:00 - 03:20 O19. Selenoprotein T is a novel target for PACAP signaling discovered via functional coupled transcriptome array and gene silencing.
06:30 - 07:00 AL1. Akira Arimura Young Investigator Award
07:00 - 08:30 Dinner
08:30 - 10:30 Poster Session I - Manchester Room
Thursday, September 6, 2007
07:30 - 08:30 Breakfast/Poster Session II Assembly and Preview
Session 6: VIP, PACAP and related peptide receptors: structure and pharmacology.
08:30 - 09:00 SL7. Receptors for VIP and PACAP: state of the art and perspectives.
09:00 - 09:20 O20. Mapping the oligomerization interface and establishing function of secretin receptor homo-oligomers.
09:20 - 09:40 O21. Development of PACAP analogs with high activity and improved metabolic stability.
09:40 - 10:10 SL8. Pharmacology of vasoactive intestinal peptide (VIP) and receptor cellular signaling in pancreatic acinar cells.
10:10 - 10:30 Break
Session 7: Physiological insights from VIP/PACAPergic system knockout animals.
10:30 - 11:00 SL9. PACAP gene knockout mouse: trouble in the hypothalamus?
11:00 - 11:20 O22. Evidence that the PACAP gene contributes to the risk of schizophrenia.
11:20 - 11:40 O23. Characterization of the VPAC1 null mouse.
11:40 - 12:00 O24. Perception of sensory modality in mice lacking PAC1 receptor performing on memory tasks.
12:00 - 12:20 O25. Blunted glucose response to stress in VPAC1 -/- mice.
12:20 - 01:30 Lunch
Session 8: VIP and PACAP peptides in clinical therapeutics.
01:30 - 02:00 SL10. VIP drug discovery and development: focusing on the neurotprotective drug candidate NAP.
02:00 - 02:20 O26. Human VIP-alpha: a novel long-acting biocompatible, biodegradable and safe disease modifying nanomedicine for rheumatoid arthritis.
02:20 - 02:40 O27. VIP as an essential modulator of the pulmonary circulation.
02:40 - 03:00 O28. Function of pulmonary PAC1 receptor in a murine model of allergic asthma.
03:00 - 03:20 O29. Functional liposomes as retard formulation for vasoactive intestinal peptide.
03:20 - 03:40 O30. PACAP prevents toxicity induced by cisplatin in primate and rat neurons but not ovarian cells.
06:30 - 07:00 AL2. Viktor Mutt Award Lecture GEP peptides powerfully influence appetite - an ongoing story.
07:00 - 08:30 Banquet Dinner
08:30 - 10:30 Poster Session II - Manchester Room
Friday, September 7, 2007
07:30 - 09:00 Breakfast and departure preparation
Session 9: G protein-coupled VIP/PACAP receptor signaling and interactive pathways.
09:00 - 09:30 SL11. PACAP signaling: a paradigm for homeostatic response to stress through combinatorial activation of multiple pathways.
09:30 - 09:50 O31. Combinatorial regulation of Ier3 (PACAP-regulated gene I) transcription and ERK activation by cAMP and calcium.
09:50 - 10:10 O32. A novel cAMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation.
10:10 - 10:30 O33. The bovine PAC1HOP receptor: insights into PACAP signaling through calcium in neuronal cell function.
10:30 - 10:50 O34. PACAP receptor amplification of long-term potentiation at CA3 - CA1 hippocampal synapses.
10:50 - 11:20 SL12. Special Symposium Lecture VIP & related peptides: The long road from discovery to drug development.
11:20 - 11:30 Closing remarks
11:30 Preparation and Departure for Shelburne Museum/Burlington, VT
Saturday, September 8, 2007
Neural stem cells and therapeutics: current strategies and developments Davis Auditorium - Fletcher Allen Health Care/University of Vermont College of Medicine
08:30 - 09:00 Coffee and continental breakfast/Davis Auditorium
09:00 - 10:00 Stem cell biology and regenerative neuroscience
10:00 - 11:00
11:00 - 12:00 Finding Therapeutics for Neurological Diseases in Academic Settings
12:00 Lunch - Fleming Art Museum/University of Vermont
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