Publications

  • 2016

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  • Features and Determinants of Lacune Shape: Relationship With Fiber Tracts and Perforating Arteries.
    Gesierich B, Duchesnay E, Jouvent E, Chabriat H, Schmidt R, Mangin JF, Duering M, Dichgans M.

    Stroke. 2016 May;47(5):1258-64. [PubMed]

  • Shape of the Central Sulcus and Disability After Subcortical Stroke: A Motor Reserve Hypothesis.
    Jouvent E, Sun ZY, De Guio F, Duchesnay E, Duering M, Ropele S, Dichgans M, Mangin JF, Chabriat H.

    Stroke. 2016 Apr;47(4):1023-9. [PubMed]

  • Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.
    Capone C, Cognat E, Ghezali L, Baron-Menguy C, Aubin D, Mesnard L, Stöhr H, Domenga-Denier V, Nelson MT, Joutel A.

    Ann Neurol. 2016 Mar;79(3):387-403. [PubMed]

  • APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.
    Gesierich B, Opherk C, Rosand J, Gonik M, Malik R, Jouvent E, Hervé D, Adib-Samii P, Bevan S, Pianese L, Silvestri S, Dotti MT, De Stefano N, van der Grond J, Boon EM, Pescini F, Rost N, Pantoni L, Oberstein SA, Federico A, Ragno M, Markus HS, Tournier-Lasserve E, Chabriat H, Dichgans M, Duering M, Ewers M.

    J Cereb Blood Flow Metab. 2016 Jan;36(1):199-203. [PubMed]

  • Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Prospective Cohort Study.
    Chabriat H, Hervé D, Duering M, Godin O, Jouvent E, Opherk C, Alili N, Reyes S, Jabouley A, Zieren N, Guichard JP, Pachai C, Vicaut E, Dichgans M.

    Stroke. 2016 Jan;47(1):4-11. [PubMed]

  • Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury?
    Seidel JL, Escartin C, Ayata C, Bonvento G, Shuttleworth CW.

    Glia. 2016 Jan;64(1):5-20. [PubMed]

  • 2015

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  • Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.
    Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, Ferrari MD, van den Maagdenberg AM, Bacskai BJ, Ayata C.

    Ann Neurol. 2015 Aug;78(2):193-210. [PubMed]

  • Consensus statement for diagnosis of subcortical small vessel disease.
    Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V.

    J Cereb Blood Flow Metab. 2015 Jul 22. doi: 10.1038/jcbfm.2015.172. [Epub ahead of print] Review. [PubMed]

  • Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.
    Ayata C, Lauritzen M.

    Physiol Rev. 2015 Jul;95(3):953-93. [PubMed]

  • Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.
    Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD.

    Hypertension. 2015 Jul;66(1):211-20. [PubMed]

  • The migraine-stroke connection: A genetic perspective.
    Malik R, Winsvold B, Auffenberg E, Dichgans M, Freilinger T.

    Cephalalgia. 2015 Dec 9. pii: 0333102415621055. [Epub ahead of print]. [PubMed]

  • Prevalence and characteristics of migraine in CADASIL.
    Guey S, Mawet J, Hervé D, Duering M, Godin O, Jouvent E, Opherk C, Alili N, Dichgans M, Chabriat H.

    Cephalalgia. 2015 Dec 7. pii: 0333102415620909. [Epub ahead of print]. [PubMed]

  • Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
    Ghosh M, Balbi M, Hellal F, Dichgans M, Lindauer U, Plesnila N.

    Ann Neurol. 2015 Dec;78(6):887-900. [PubMed]

  • Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.
    Verdura E, Hervé D, Scharrer E, Amador Mdel M, Guyant-Maréchal L, Philippi A, Corlobé A, Bergametti F, Gazal S, Prieto-Morin C, Beaufort N, Le Bail B, Viakhireva I, Dichgans M, Chabriat H, Haffner C, Tournier-Lasserve E.

    Brain. 2015 Aug;138(Pt 8):2347-58. [PubMed]

  • Common NOTCH3 Variants and Cerebral Small-Vessel Disease.
    Rutten-Jacobs LC, Traylor M, Adib-Samii P, Thijs V, Sudlow C, Rothwell PM, Boncoraglio G, Dichgans M, Bevan S, Meschia J, Levi C, Rost NS, Rosand J, Hassan A, Markus HS.

    Stroke. 2015 Jun;46(6):1482-7. [PubMed]

  • Dysfunction of mouse cerebral arteries during early aging.
    Balbi M, Ghosh M, Longden TA, Jativa Vega M, Gesierich B, Hellal F, Lourbopoulos A, Nelson MT, Plesnila N.

    J Cereb Blood Flow Metab. 2015 Jun 10. doi: 10.1038/jcbfm.2015.107. [Epub ahead of print]. [PubMed]

  • A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient.
    Khaleeli Z, Jaunmuktane Z, Beaufort N, Houlden H, Haffner C, Brandner S, Dichgans M, Werring D.

    J Neurol. 2015 May;262(5):1369-72. [PubMed]

  • The Glymphatic System: A Beginner's Guide.
    Jessen NA, Munk AS, Lundgaard I, Nedergaard M.

    Neurochem Res. 2015 May 7. [Epub ahead of print]. [PubMed]

  • Why have we not yet developed a simple blood test for TBI?
    Plog BA, Nedergaard M.

    Expert Rev Neurother. 2015 May;15(5):465-8. [PubMed]

  • APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.
    Gesierich B, Opherk C, Rosand J, Gonik M, Malik R, Jouvent E, Hervé D, Adib-Samii P, Bevan S, Pianese L, Silvestri S, Dotti MT, De Stefano N, van der Grond J, Boon EM, Pescini F, Rost N, Pantoni L, Lesnik Oberstein SA, Federico A, Ragno M, Markus HS, Tournier-Lasserve E, Chabriat H, Dichgans M, Duering M, Ewers M.

    J Cereb Blood Flow Metab. 2015 Apr 29. doi: 10.1038/jcbfm.2015.85. [Epub ahead of print]. [PubMed]

  • Genetic factors in cerebral small vessel disease and their impact on stroke and dementia.
    Haffner C, Malik R, Dichgans M.

    J Cereb Blood Flow Metab. 2015 Apr 22. doi: 10.1038/jcbfm.2015.71. [Epub ahead of print] Review. [PubMed]

  • Perturbations of the cerebrovascular matrisome: a convergent mechanism in small vessel disease of the brain?
    Joutel A, Haddad I, Ratelade J, Nelson MT.

    J Cereb Blood Flow Metab. 2015 Apr 8. doi: 10.1038/jcbfm.2015.62. [Epub ahead of print] Review. [PubMed]

  • Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro.
    Wollenweber FA, Hanecker P, Bayer-Karpinska A, Malik R, Bäzner H, Moreton F, Muir KW, Müller S, Giese A, Opherk C, Dichgans M, Haffner C, Duering M.

    Stroke. 2015 Mar;46(3):786-92. [PubMed]

  • Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.
    Dabertrand F, Krøigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.

    Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E796-805. [PubMed]

  • Reaction Time is a Marker of Early Cognitive and Behavioral Alterations in Pure Cerebral Small Vessel Disease.
    Jouvent E, Reyes S, De Guio F, Chabriat H.

    J Alzheimers Dis. 2015;47(2):413-9. [PubMed]

  • White matter edema at the early stage of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
    De Guio F, Mangin JF, Duering M, Ropele S, Chabriat H, Jouvent E.

    Stroke. 2015 Jan;46(1):258-61. [PubMed]

  • 2014

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  • Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.
    Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, Dichgans M.

    Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16496-501. [PubMed]

  • CADASIL and CARASIL.
    Tikka S, Baumann M, Siitonen M, Pasanen P, Pöyhönen M, Myllykangas L, Viitanen M, Fukutake T, Cognat E, Joutel A, Kalimo H.

    Brain Pathol. 2014 Sep;24(5):525-44. [PubMed]

  • Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits.
    Kast J, Hanecker P, Beaufort N, Giese A, Joutel A, Dichgans M, Opherk C, Haffner C.

    Acta Neuropathol Commun. 2014 Aug 13;2(1):96. [PubMed]

  • In Vivo High-Resolution 7 Tesla MRI Shows Early and Diffuse Cortical Alterations in CADASIL.
    De Guio F, Reyes S, Vignaud A, Duering M, Ropele S, Duchesnay E, Chabriat H, Jouvent E.

    PLoS One. 2014 Aug 28;9(8):e106311. [PubMed]

  • Loss of venous integrity in cerebral small vessel disease: a 7-T MRI study in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
    De Guio F, Vignaud A, Ropele S, Duering M, Duchesnay E, Chabriat H, Jouvent E.

    Stroke. 2014 Jul;45(7):2124-6. [PubMed]

  • ADC Histograms from Routine DWI for Longitudinal Studies in Cerebral Small Vessel Disease: A Field Study in CADASIL.
    Gunda B, Porcher R, Duering M, Guichard JP, Mawet J, Jouvent E, Dichgans M, Chabriat H.

    PLoS One. 2014 May 12;9(5):e97173. [PubMed]

  • Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model.
    Cognat E, Cleophax S, Domenga-Denier V, Joutel A.

    Acta Neuropathol Commun. 2014 Apr 30;2:49. [PubMed]

  • Cerebral Small Vessel Disease: Insights and Opportunities From Mouse Models of Collagen IV−Related Small Vessel Disease and Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.
    Joutel A, Faraci FM.

    Stroke. 2014 Apr;45(4):1215-21. [PubMed]

  • Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.
    Opherk C, Gonik M, Duering M, Malik R, Jouvent E, Hervé D, Adib-Samii P, Bevan S, Pianese L, Silvestri S, Dotti MT, De Stefano N, Liem M, Boon EM, Pescini F, Pachai C, Bracoud L, Müller-Myhsok B, Meitinger T, Rost N, Pantoni L, Lesnik Oberstein S, Federico A, Ragno M, Markus HS, Tournier-Lasserve E, Rosand J, Chabriat H, Dichgans M.

    Stroke. 2014 Apr;45(4):968-72. [PubMed]

  • Dilated perivascular spaces in small-vessel disease: a study in CADASIL.
    Yao M, Hervé D, Jouvent E, Duering M, Reyes S, Godin O, Guichard JP, Dichgans M, Chabriat H.

    Cerebrovasc Dis. 2014;37(3):155-63. [PubMed]

  • Neurovascular signaling in the brain and the pathological consequences of hypertension.
    Dunn KM, Nelson MT.

    Am J Physiol Heart Circ Physiol. 2014 Jan;306(1):H1-H14. [PubMed]

  • 2013

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  • Mechanisms of enhanced basal tone of brain parenchymal arterioles during early postischemic reperfusion: role of ET-1-induced peroxynitrite generation.
    Cipolla MJ, Sweet JG, Gokina NI, White SL, Nelson MT.

    J Cereb Blood Flow Metab. 2013 Oct;33(10):1486-92. [PubMed]

  • Impact of regional cortical and subcortical changes on processing speed in cerebral small vessel disease.
    Righart R, Duering M, Gonik M, Jouvent E, Reyes S, Hervé D, Chabriat H, Dichgans M.

    Neuroimage Clin. 2013 Jun 19;2:854-61. [PubMed]

  • TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.
    Dunn KM, Hill-Eubanks DC, Liedtke WB, Nelson MT.

    Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6157-62. [PubMed]

  • Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.
    Dabertrand F, Hannah RM, Pearson JM, Hill-Eubanks DC, Brayden JE, Nelson MT.

    J Cereb Blood Flow Metab. 2013 Apr;33(4):479-82. [PubMed]

  • Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation.
    Dabertrand F, Nelson MT, Brayden JE.

    Microcirculation. 2013 May;20(4):307-16. doi: 10.1111/micc.12027. Review. [PubMed]

  • Archetypal Arg169Cys Mutation in NOTCH3 Does Not Drive the Pathogenesis in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leucoencephalopathy via a Loss-of-Function Mechanism.
    Cognat E, Baron-Menguy C, Domenga-Denier V, Cleophax S, Fouillade C, Monet-Leprêtre M, Dewerchin M, Joutel A.

    Stroke. 2014 Jan 14. [ePub Ahead of Print] [PubMed]

  • Letter by Dichgans et al regarding article, "Peripheral artery disease as a manifestation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and practical implications".
    Dichgans M, Joutel A, Chabriat H.

    Circulation. 2013 Oct 22;128(17):e363. [PubMed]

  • Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease.
    Duering M, Csanadi E, Gesierich B, Jouvent E, Hervé D, Seiler S, Belaroussi B, Ropele S, Schmidt R, Chabriat H, Dichgans M.

    Brain. 2013 Sep;136(Pt 9):2717-26. [PubMed]

  • Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL.
    Monet-Leprêtre M, Haddad I, Baron-Menguy C, Fouillot-Panchal M, Riani M, Domenga-Denier V, Dussaule C, Cognat E, Vinh J, Joutel A.

    CBrain. 2013 Jun;136(Pt 6):1830-45. [PubMed]