49 Murray Street is a one-and-one-half-story, gable-front, two bay, wood frame structure on the west side of Murray Street between Allen and North Streets. It is a vernacular construction, with few defining details. The flat roofed rear portion of the building appears to have been added very early in the building's life. It is currently undergoing a rehabilitation project.

The land on which 49 Murray Street sits had no structures on it in 1857,¹ and its first resident was probably Useb Roberge. He may have acquired the property around 1861, when Leverett B. Englesby sold the adjoining property to Joseph Levee.² Roberge moved to Murray Street in 1869,³ and it is his name that appears on the 1869 Beers Atlas Map. He sold the property again in 1870, however, to Daniel Gilmore,⁴ whose family held the property until 1916. Justin Dennis, a carpenter, bought "the same land and premises conveyed by Useb and Philomon Roberge" in 1916, and lived in the house until 1922.⁵ In 1930, 49 Murray Street was occupied by Edward J. Dorey, an electrician, and in 1940 it housed Donald G. Myott, and employee of the Hotel Vermont.⁶