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Imaging Protein Statistical Substate Occupancy in a Spectrum-Function Phase Space

TitleImaging Protein Statistical Substate Occupancy in a Spectrum-Function Phase Space
Publication TypeJournal Article
JournalPhysical Review Letters
Publication Year2010
Publication Date8/2010
Volume105
Issue9
AuthorsDeWitt, W, Chu, K
ISSN0031-9007
AbstractHemeprotein ligand rebinding studies reveal varying IR absorbance and rebinding functions across a cryogenic ensemble. Since IR-active vibrations and rebinding barriers couple to structural coordinates, spectral and functional heterogeneity arise from conformational heterogeneity. Modeling rebinding data as a spectrally resolved superposition of first-order rate processes and employing maximum entropy regularization, protein heterogeneity is imaged as an ensemble occupancy of a spectrum-function phase space. Results from myoglobin rebinding carbon monoxide are discussed.
DOI10.1103/PhysRevLett.105.098101
Short TitlePhys. Rev. Lett.
Status: 
Published
Attributable Grant: 
IRWE
Grant Year: 
Post_Grant