You are here
Imaging Protein Statistical Substate Occupancy in a Spectrum-Function Phase Space
Thu, 09/13/2012 - 8:40am — steve_exler
| Title | Imaging Protein Statistical Substate Occupancy in a Spectrum-Function Phase Space |
| Publication Type | Journal Article |
| Journal | Physical Review Letters |
| Publication Year | 2010 |
| Publication Date | 8/2010 |
| Volume | 105 |
| Issue | 9 |
| Authors | DeWitt, W, Chu, K |
| ISSN | 0031-9007 |
| Abstract | Hemeprotein ligand rebinding studies reveal varying IR absorbance and rebinding functions across a cryogenic ensemble. Since IR-active vibrations and rebinding barriers couple to structural coordinates, spectral and functional heterogeneity arise from conformational heterogeneity. Modeling rebinding data as a spectrally resolved superposition of first-order rate processes and employing maximum entropy regularization, protein heterogeneity is imaged as an ensemble occupancy of a spectrum-function phase space. Results from myoglobin rebinding carbon monoxide are discussed. |
| DOI | 10.1103/PhysRevLett.105.098101 |
| Short Title | Phys. Rev. Lett. |
