University of Vermont

Prof. Dwight E. Matthews

Matthews' refereed publications

Papers by DE Matthews in Refereed Scientific Journals:

Papers in maroon indicate works of emphasis.

  Papers from Ph.D. Thesis work at Indiana University:

1. DE Matthews & JM Hayes: Systematic errors in gas chromatography-mass spectrometry isotope ratio measurements. Anal. Chem. 48: 1375-1382, 1976.

2. JM Hayes, DE Matthews & DA Schoeller: The 'effective deadtime' of pulse-counting detector systems. Anal. Chem. 50: 25-32, 1978.

3. DE Matthews, KB Denson & JM Hayes: Evaluation of the dynamic performance of selected ion monitoring mass spectrometers. Anal. Chem. 50: 681-683, 1978.

4. DE Matthews & JM Hayes: Isotope-ratio-monitoring gas chromatography-mass spectrometry. Anal. Chem. 50: 1465-1473, 1978.

Papers from Washington University School of Medicine with D.M. Bier and from MIT with V.R. Young:

5. DE Matthews, E Ben Galim & DM Bier: Determination of stable isotopic enrichment in individual plasma amino acids by chemical ionization mass spectrometry. Anal. Chem. 51: 80-84, 1979.

6. JF Burke, RR Wolfe, CJ Mullany, DE Matthews & DM Bier: Glucose requirements following burn injury: Parameters of optimal glucose infusion and possible hepatic and respiratory abnormalities following excessive glucose intake. Ann. Surg. 190: 274-285, 1979.

Matthews & Bier

1978 Photo of Dennis Bier & Dwight Matthews
Click here to play the Dutch Dennis Bier song

7. DE Matthews, KJ Motil, DK Rohrbaugh, JF Burke, VR Young & DM Bier: Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-13C]leucine. Am. J. Physiol. Endocrinol. Metab. 238: E473-E479, 1980.

8. DE Matthews, E Ben Galim, MW Haymond & DM Bier: Alloisoleucine formation in Maple Syrup Urine Disease: Isotopic evidence for the mechanism. Pediatr. Res. 14: 854-857, 1980.

9. E Ben Galim, K Hruska, DM Bier, DE Matthews & MW Haymond: Branched-chain amino acid nitrogen transfer to alanine in vivo: Direct isotopic determination with [15N]leucine. J. Clin. Invest. 66: 1295-1304, 1980.

10. M Gersovitz, DM Bier, DE Matthews, J Udall, HN Munro & VR Young: Dynamic aspects of whole body glycine metabolism: Influence of protein intake in young adult and elderly males. Metabolism 29: 1087-1094, 1980.

11. DE Matthews, JB Starren, AJ Drexler, DM Kipnis & DM Bier: Picomole assay for Nτ-methylhistidine by gas chromatography-mass spectrometry. Anal. Biochem. 110: 308-317, 1981.

12. KJ Motil, DE Matthews, DM Bier, JF Burke, HN Munro & VR Young: Whole body leucine and lysine metabolism: Response to altered dietary protein intake in young men. Am. J. Physiol. Endocrinol. Metab. 240:E712-E721, 1981.

13. KJ Motil, DM Bier, DE Matthews, JF Burke & VR Young: Whole body leucine and lysine metabolism studied with [1-13C]leucine and [α-15N]lysine: Response in healthy young men given excess energy intake. Metabolism 30: 783-791, 1981.

14. DE Matthews, DM Bier, MJ Rennie, RHT Edwards, D Halliday, DJ Millward & GA Clugston: Regulation of leucine metabolism in man: A stable isotope study. Science 214: 1129-1131, 1981.

15. DE Matthews, JM Conway, VR Young & DM Bier: Glycine nitrogen metabolism in man. Metabolism 30: 886-893, 1981.

16. R Matalon, DE Matthews, K Michals & DM Bier: The use of deuterated phenylalanine for the in vivo assay of phenylalanine hydroxylase activity in children. J. Inherited Metab. Dis. 5: 17-19, 1982.

17. KJ Motil, RJ Grand, DE Matthews, DM Bier, CJ Maletskos & VR Young: Whole body leucine metabolism in adolescents with Crohn's disease and growth failure during nutritional supplementation. Gastroenterology 82: 1359-1368, 1982.

18. MJ Rennie, RHT Edwards, D Halliday, DE Matthews, SL Wolman & DJ Millward: Muscle protein synthesis measured by stable isotope techniques in man: The effects of feeding and fasting. Clin. Sci. 63: 519-523, 1982.

19. MJ Rennie, RHT Edwards, DJ Millward, SL Wolman, D Halliday & DE Matthews: The effects of Duchenne muscular dystrophy on muscle protein synthesis. Nature 296: 165-167, 1982.

20. WJ Malaisse, A Sener, F Malaisse-Lagae, M Welsh, DE Matthews, DM Bier & C Hellerstrom: The stimulus-secretion coupling of amino acid-induced insulin release: Metabolic response of pancreatic islets to L-glutamine and L-leucine. J. Biol. Chem. 257: 8731-8737, 1982.

21. DM Bier & DE Matthews: Stable isotope tracer methods for in vivo investigations. Fed. Proc. 41: 2679-2685, 1982.

22. DJ Millward, CTM Davies, D Halliday, SL Wolman, DE Matthews & MJ Rennie: Effect of exercise on protein metabolism in humans as explored with stable isotopes. Fed. Proc. 41: 2686-2691, 1982.

23. DE Matthews, HP Schwarz, RD Yang, KJ Motil, VR Young & DM Bier: Relationship of plasma leucine and α-ketoisocaproate during a L-[1-13C]leucine infusion in man: A method for measuring human intracellular leucine tracer enrichment. Metabolism 31: 1105-1112, 1982.

24. JJ Robert, DM Bier, X-H Zhao, DE Matthews & VR Young: Glucose and insulin effects on de novo amino acid synthesis in young men: Studies with stable isotope labeled alanine, glycine, leucine, and lysine. Metabolism 31: 1210-1218, 1982.

25. JJ Robert, JC Cummins, RR Wolfe, M Durkot, DE Matthews, X-H Zhao, DM Bier & VR Young: Quantitative aspects of glucose production and metabolism in healthy elderly subjects. Diabetes 31: 203-211, 1982.

26. MWN Ward, D Halliday, DE Matthews, SM Matthews, JL Peters, RA Harrison, CG Clark & MJ Rennie: The effect of enteral nutritional support on skeletal muscle protein synthesis and whole-body protein turnover in fasted surgical patients. Hum. Nutr. Clin. Nutr. 37: 453-458, 1983.

27. RD Yang, LL Moldawer, A Sakamoto, RA Keenan, DE Matthews, VR Young, RW Wannemacher, Jr., GL Blackburn & BR Bistrian: Leukocyte endogenous mediator alters protein dynamics in rats. Metabolism 32: 654-660, 1983.

28. JE Heubi, S Burstein, MA Sperling, D Gregg, MTR Subbiah & DE Matthews: The role of human growth hormone in the regulation of cholesterol and bile acid metabolism. J. Clin. Endocrinol. Metab. 57: 885-891, 1983.

29. EJ Norman, JE Heubi, MJ Gelfand, P Dan & DE Matthews: Chenodeoxycholic acid pool size determination from children using isotope dilution mass spectrometry. Biomed. Mass Spectrom. 11: 269-272, 1984.

30. MA Staten, DM Bier & DE Matthews: Regulation of valine metabolism in man: A stable isotope study. Am. J. Clin. Nutr. 40:1224-1234, 1984.

31. DE Matthews & RS Downey: Measurement of urea kinetics in humans: A validation of stable isotope tracer methods. Am. J. Physiol. Endocrinol. Metab. 246: E519-E527, 1984.

32. RD Yang, DE Matthews, DM Bier, C Lo & VR Young: Alanine kinetics in man: Influence of different isotopic tracers. Am. J. Physiol. Endocrinol. Metab. 247: E634-E638, 1984.

33. LJ Hoffer, BR Bistrian, VR Young, GL Blackburn & DE Matthews: Metabolic effects of very low calorie weight reduction diets. J. Clin. Invest. 73: 750-758, 1984.

34. RA Gelfand, DE Matthews, DM Bier & RS Sherwin: Role of counterregulatory hormones in the catabolic response to stress. J. Clin. Invest. 74: 2238-2248, 1984.

35. JJ Robert, DM Bier, D Schoeller, RR Wolfe, DE Matthews, HN Munro & VR Young: Effects of intravenous glucose on whole body leucine dynamics, studied with 1-13C-leucine, in healthy young and elderly adults. J. Gerontol. 39: 673-681, 1984.

36. LJ Hoffer, RD Yang, DE Matthews, BR Bistrian, DM Bier & VR Young: Effects of meal consumption on whole body leucine and alanine kinetics in young adult men. Br. J. Nutr. 53: 31-38, 1985.

37. D Darmaun, MJ Manary & DE Matthews: A method for measuring both glutamine and glutamate levels in stable isotopic enrichments. Anal. Biochem. 147: 92-102, 1985.

38. YM Yu, RD Yang, DE Matthews, Z-M Wen, JF Burke, DM Bier & VR Young: Quantitative aspects of glycine and alanine metabolism in postabsorptive young men: Effects of level of nitrogen and indispensable amino acid intake. J. Nutr. 115: 399-410, 1985.

39. WJ Millikan, JM Henderson, JR Galloway, WD Warren, DE Matthews, A McGhee & MH Kutner: In vivo measurement of leucine metabolism with stable isotopes in normal and cirrhotic subjects fed conventional and branched-chain amino acid enriched diets. Surgery 98: 405-412, 1985.

40. NK Fukagawa, KL Minaker, JW Rowe, MN Goodman, DE Matthews, DM Bier & VR Young: Insulin-mediated reduction of whole body protein breakdown: Dose-response effects of leucine metabolism in postabsorptive men. J. Clin. Invest. 76: 2306-2311, 1985.

41. RS Downey, WW Monafo, IE Karl, DE Matthews & DM Bier: Protein dynamics in skeletal muscle after trauma: Local and systemic effects. Surgery 99: 265-273, 1986.

42. RS Downey, A Mellone & DE Matthews: Effects of tracer infusion site on measurement of bicarbonate-carbon dioxide metabolism in dogs. J. Appl. Physiol. 60: 1248-1253, 1986.

43. MM Meguid, DE Matthews, DM Bier, CN Meredith, JS Soeldner & VR Young: Leucine kinetics at graded leucine intakes in young men. Am. J. Clin. Nutr. 43: 770-780, 1986.

44. MM Meguid, DE Matthews, DM Bier, CN Meredith & VR Young: Valine kinetics at graded valine intakes in young men. Am. J. Clin. Nutr. 43: 781-786, 1986.

45. CN Meredith, Z-M Wen, DM Bier, DE Matthews & VR Young: Lysine kinetics at graded lysine intakes in young men. Am. J. Clin. Nutr. 43: 787-794, 1986.

46. X-H Zhao, Z-M Wen, CN Meredith, DE Matthews, DM Bier & VR Young: Threonine kinetics at graded threonine intakes in young men. Am. J. Clin. Nutr. 43: 795-802, 1986.

47. MA Staten, DE Matthews & DM Bier: Leucine metabolism in type II diabetes mellitus. Diabetes 35: 1249-1253, 1986.

48. VR Young, NK Fukagawa, DM Bier & DE Matthews: Some aspects of in vivo human protein and amino acid metabolism, with particular reference to nutritional modulation. Verh. Dtsch. Ges. Inn. Med. 92: 640-665, 1986.

49. RD Yang, DE Matthews, DM Bier, Z-M Wen & VR Young: Response of alanine metabolism in humans to manipulation of dietary protein and energy intakes. Am. J. Physiol. Endocrinol. Metab. 250: E39-E46, 1986.

50. D Darmaun, DE Matthews & DM Bier: Glutamine and glutamate kinetics in humans. Am. J. Physiol. Endocrinol. Metab. 251: E117-E126, 1986.

51. VR Young, C Gucalp, WM Rand, DE Matthews & DM Bier: Leucine kinetics during three weeks at submaintenance-to-maintenance of leucine in men: Adaption and accommodation. Hum. Nutr. Clin. Nutr. 41: 1-18, 1987.

52. SJ Fomon, DE Matthews, DM Bier, RR Rogers, CJ Rebouche, BB Edwards & SE Nelson: Bioavailability of dietary urea nitrogen in the infant. J. Pediatr. 111: 221-224, 1987.

53. KS Nair, D Halliday, DE Matthews & SL Welle: Hyperglucagonemia during insulin deficiency accelerates protein catabolism. Am. J. Physiol. Endocrinol. Metab. 253: E208-E213, 1987.

54. D Darmaun, DE Matthews, J-F Desjeux & DM Bier: Glutamine and glutamate nitrogen exchangeable pools in cultured fibroblasts: A stable isotope study. J. Cell. Physiol. 134: 143-148, 1988.

55. KS Nair, PD Woolf, SL Welle & DE Matthews: Leucine, glucose, and energy metabolism after 3 days of fasting in healthy human subjects. Am. J. Clin. Nutr. 46: 557-562, 1987.

56. MA Staten, DE Matthews, PE Cryer & DM Bier: Physiologic increments in epinephrine stimulate metabolic rate in humans. Am. J. Physiol. Endocrinol. Metab. 253: E322-E330, 1987.

57. KJ Tracey, A Legaspi, JD Albert, M Jeevanandam, DE Matthews, MF Brennan & SF Lowry: Protein and substrate metabolism during starvation and parenteral refeeding. Clin. Sci. 74: 123-132, 1988.

58. NK Fukagawa, KL Minaker, JW Rowe, DE Matthews, DM Bier & VR Young: Glucose and amino acid metabolism in aging man: Differential effects of insulin. Metabolism 37: 371-377, 1988.

59. SJ Fomon, DM Bier, DE Matthews, RR Rogers, BB Edwards, EE Ziegler & SE Nelson: Bioavailability of dietary urea nitrogen in the breast-fed infant. J. Pediatr. 113: 515-517, 1988.

60. J Cortiella, DE Matthews, RA Hoerr, DM Bier & VR Young: Leucine kinetics at graded intakes in young men: Quantitative fate of dietary leucine. Am. J. Clin. Nutr. 48: 988-1009, 1988.

61. LJ Hoffer, RD Yang, DE Matthews, BR Bistrian, DM Bier & VR Young: Alanine flux in obese and healthy humans as evaluated by 15N- and 2H3-labeled alanines. Am. J. Clin. Nutr. 48: 1010-1014, 1988.

62. D Darmaun, DE Matthews & DM Bier: Physiological hypercortisolemia increases proteolysis, glutamine and alanine production. Am. J. Physiol. Endocrinol. Metab. 255: E366-E373, 1988.

63. NK Fukagawa, KL Minaker, VR Young, DE Matthews, DM Bier & JW Rowe: Leucine metabolism in aging humans: Effect of insulin and substrate availability. Am. J. Physiol. Endocrinol. Metab. 256: E288-E294, 1989.

64. MA Staten, DE Matthews, PE Cryer & DM Bier: Epinephrine's effect on metabolic rate is independent of changes in plasma insulin or glucagon. Am. J. Physiol. Endocrinol. Metab. 257: E185-E192, 1989.

Papers from Cornell University Medical College:

65. Y Fong, M Rosenbaum, KJ Tracey, G Raman, DG Hesse, DE Matthews, RL Leibel, JM Gertner, DA Fischman & SF Lowry: Recombinant growth hormone enhances muscle myosin heavy-chain mRNA accumulation and amino acid accrual in humans. Proc. Natl. Acad. Sci. U. S. A. 86: 3371-3374, 1989.

66. JD Albert, DE Matthews, A Legaspi, KJ Tracey, M Jeevanandam, MF Brennan & SF Lowry: Exercise-mediated peripheral tissue and whole-body amino acid metabolism during intravenous feeding in normal man. Clin. Sci. 77: 113-120, 1989.

67. S Welle, DE Matthews, RG Campbell & KS Nair: Stimulation of protein turnover by carbohydrate overfeeding in men. Am. J. Physiol. Endocrinol. Metab. 257: E413-E417, 1989.

Matthews at Cornell

1992 Photo Taken in Dr. Matthews' Laboratory at the Cornell University Medical College

68. B Beaufrère, FF Horber, WF Schwenk, HM Marsh, DE Matthews, JE Gerich & MW Haymond: Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. Am. J. Physiol. Endocrinol. Metab. 257: E712-E721, 1989.

69. K Casper, DE Matthews & SB Heymsfield: Overfeeding: Cardiovascular and metabolic response during continuous formula infusion in adult humans. Am. J. Clin. Nutr. 52: 602-609, 1990.

70. NS Kwon, CF Nathan, C Gilker, OW Griffith, DE Matthews & DJ Stuehr: L-Citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. J. Biol. Chem. 265: 13442-13445, 1990.

71. GR Pesola, JE Hogg, N Eissa, DE Matthews & GC Carlon: Hypertonic nasogastric tube feedings: Do they cause diarrhea? Crit. Care Med. 18: 1378-1382, 1990.

72. C Couet, NK Fukagawa, DE Matthews, DM Bier & VR Young: Plasma amino acid kinetics during acute states of glucagon deficiency and excess in healthy adults. Am. J. Physiol. Endocrinol. Metab. 258: E78-E85, 1990.

73. DE Matthews, G Pesola & RG Campbell: Effect of epinephrine upon amino acid and energy metabolism in humans. Am. J. Physiol. Endocrinol. Metab. 258: E948-E956, 1990.

74. M Yagi, DE Matthews & M Walser: Nitrogen sparing by 2-ketoisocaproate in parenterally fed rats. Am. J. Physiol. Endocrinol. Metab. 259: E633-E638, 1990.

75. RA Hoerr, DE Matthews, DM Bier & VR Young: Leucine kinetics from [2H3]- and [13C]leucine infused simultaneously by gut and vein. Am. J. Physiol. Endocrinol. Metab. 260: E111-E117, 1991.

76. DE Matthews & C Cobelli: Leucine metabolism in man: Lessons from modeling. JPEN J. Parenter. Enteral Nutr. 15: 86S-89S, 1991.

77. C Cobelli, MP Saccomani, P Tessari, G Biolo, L Luzi & DE Matthews: A compartmental model of leucine kinetics in humans. Am. J. Physiol. Endocrinol. Metab. 261: E539-E550, 1991.

78. DE Matthews, GR Pesola & V Kvetan: Glycerol metabolism in humans: Validation of 2H and 13C-labeled tracers. Acta Diabetol. 28: 179-184, 1991.

79. Y Fong, JD Albert, KJ Tracey, DG Hesse, S Calvano, DE Matthews & SF Lowry: The influence of substrate background on the acute metabolic response to epinephrine and cortisol. J. Trauma 31: 1467-1476, 1991.

80. DE Matthews & RG Campbell: The effect of dietary protein intake upon glutamine and glutamate nitrogen metabolism in humans. Am. J. Clin. Nutr. 55: 963-970, 1992.

81. KS Nair, DE Matthews, SL Welle & T Braiman: Effect of leucine on amino acid and glucose metabolism in humans. Metabolism 41: 643-648, 1992.

82. CD Gilker, GR Pesola & DE Matthews: A mass spectrometric method for measuring glycerol levels and enrichments in plasma using 13C and 2H stable isotopic tracers. Anal. Biochem. 205: 172-178, 1992.

Drs Matthews & Wutzke at NYH CRC

Photo of Drs. Klaus Wutzke (in the bed) & Matthews in the New York Hospital CRC performing a tracer infusion study during a fellowship by Dr. Wutzke (presently at the Universität Rostock, Rostock, Germany)

83. SW Lichtman, K Pisarska, E Raynes-Berman, M Pestone, H Dowling, E Offenbacher, H Weisel, S Heshka, DE Matthews & SB Heymsfield: Discrepancy between self-reported and actual caloric intake and exercise in obese subjects. N. Engl. J. Med. 327: 1893-1898, 1992.

84. DE Matthews: Stable isotope methodologies in studying human amino acid and protein metabolism. Ital. J. Gastroenterol. 25: 72-78, 1993.

85. DE Matthews, A Battezzati & P Fürst: Alanylglutamine kinetics in humans. Clin. Nutr. 12: 57-58, 1993.

86. DE Matthews, MA Marano & RG Campbell: Splanchnic bed utilization of leucine and phenylalanine in humans. Am. J. Physiol. Endocrinol. Metab. 264: E109-E118, 1993.

87. RA Hoerr, DE Matthews, DM Bier & VR Young: Effects of protein restriction and acute refeeding on leucine and lysine kinetics in young men. Am. J. Physiol. Endocrinol. Metab. 264: E567-E575, 1993.

88. DE Matthews, MA Marano & RG Campbell: Splanchnic bed utilization of glutamine and glutamic acid in humans. Am. J. Physiol. Endocrinol. Metab. 264: E848-E854, 1993.

89. WH Martin, III, GP Dalsky, BF Hurley, DE Matthews, DM Bier, JM Hagberg, MA Rogers, DS King & JO Holloszy: Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. Am. J. Physiol. Endocrinol. Metab. 265: E708-E714, 1993.

90. E Vlachopapadopoulou, KJ Tracey, M Capella, C Gilker & DE Matthews: Increased energy expenditure in a patient with diencephalic syndrome. J. Pediatr. 122: 922-924, 1993.

91. AS Petrides, D Schulze-Berge, C Vogt, DE Matthews & G Strohmeyer: Glucose resistance contributes to diabetes mellitus in cirrhosis. Hepatology 18: 284-291, 1993.

92. RE Ostlund, Jr. & DE Matthews: [13C]Cholesterol as a tracer for studies of cholesterol metabolism in man. J. Lipid Res. 34: 1825-1831, 1993.

93. Y Fong, DE Matthews, W He, MA Marano, LL Moldawer & SF Lowry: Whole body and splanchnic leucine, phenylalanine, and glucose kinetics during endotoxemia in humans. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 266: R419-R425, 1994.

94. A-C Möller-Loswick, H Zachrisson, A Hyltander, U Körner, DE Matthews & K Lundholm: Insulin selectively attenuates breakdown of nonmyofibrillar proteins in peripheral tissues of normal men. Am. J. Physiol. Endocrinol. Metab. 266: E645-E652, 1994.

95. DJ Brillon, B Zheng, RG Campbell & DE Matthews: Effect of cortisol on energy expenditure and amino acid metabolism in humans. Am. J. Physiol. Endocrinol. Metab. 268: E501-E513, 1995.

96. A Battezzati, DJ Brillon & DE Matthews: Oxidation of glutamic acid by the splanchnic bed in humans. Am. J. Physiol. Endocrinol. Metab. 269: E269-E276, 1995.

97. DE Matthews & CD Gilker: Impact of 2H and 18O pool size determinations on the calculation of total energy expenditure. Obes. Res. 3: 21-29, 1995.

98. KM Buhl, D Gallagher, K Hoy, DE Matthews & SB Heymsfield: Unexplained disturbance in body weight regulation: Diagnostic outcome assessed by doubly labeled water and body composition analyses in obese patients reporting low energy intakes. J. Am. Diet. Assoc. 95: 1393-1400, 1995.

99. M Rosenbaum, E Ravussin, DE Matthews, C Gilker, R Ferraro, SB Heymsfield, J Hirsch & RL Leibel: A comparative study of different means of assessing long-term energy expenditure in humans. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 270: R496-R504, 1996.

100. E Svanberg, A-C Möller-Loswick, DE Matthews, U Körner, M Andersson & K Lundholm: Effects of amino acids on synthesis and degradation of skeletal muscle proteins in humans. Am. J. Physiol. Endocrinol. Metab. 271: E718-E724, 1996.

101. Z-M Wang, D Gallagher, M Nelson, DE Matthews & SB Heymsfield: Total body skeletal muscle mass: Evaluation of 24-h urinary creatinine excretion by computerized axial tomography. Am. J. Clin. Nutr. 63: 863-869, 1996.

  Papers from the University of Vermont:

102. M Schiefermeier, KM Ratheiser, C Zauner, E Roth, HG Eichler & DE Matthews: Epinephrine does not impair utilization of exogenous amino acids in humans. Am. J. Clin. Nutr. 65: 1765-1773, 1997.

103. AS Petrides, DE Matthews & U Esser: Effect of moderate exercise on insulin sensitivity and substrate metabolism during post-exercise recovery in cirrhosis. Hepatology 26: 972-979, 1997.

104. Z-M Wang, P Deurenberg, DE Matthews & SB Heymsfield: Urinary 3-methylhistidine excretion: Association with total body skeletal muscle mass by computerized axial tomography. JPEN J. Parenter. Enteral Nutr.22: 82-86, 1998.

Matthews at Sugarbush

March 1999: Dr. Matthews & son, Tom, at Sugarbush

105. W Bäurle, H Brösicke, DE Matthews, K Pogan & P Fürst: Metabolism of parenterally administered fat emulsions in the rat: studies of fatty acid oxidation with 1-13C- and 8-13C-labelled triolein. Br. J. Nutr. 79: 381-387, 1998.

106. A Battezzati, DC Simonson, L Luzi & DE Matthews: Glucagon increases glutamine uptake without affecting glutamine release in humans. Metabolism 47: 713-723, 1998.

107. RD Starling, MJ Toth, WH Carpenter, DE Matthews & ET Poehlman: Energy requirements and physical activity in free-living older women and men: A doubly labeled water study. J. Appl. Physiol. 85: 1063-1069, 1998.

108. RD Starling, MJ Toth, DE Matthews & ET Poehlman: Energy requirements and physical activity of older free-living African-Americans: A doubly labeled water study. J. Clin. Endocrinol. Metab. 83: 1529-1534, 1998.

109. E García-Rubi, RD Starling, A Tchernof, DE Matthews, JD Walston, AR Shuldiner, K Silver, ET Poehlman & J Calles-Escandón: Trp64Arg variant of the β3-adrenoceptor and insulin resistance in obese postmenopausal women. J. Clin. Endocrinol. Metab. 83: 4002-4005, 1998.

110. AS Petrides, T Stanley, DE Matthews, C Vogt, AJ Bush & H Lambeth: Insulin resistance in cirrhosis: Prolonged reduction of hyperinsulinemia normalizes insulin sensitivity. Hepatology 28: 141-149, 1998.

111. BAC van Acker, KWE Hulsewé, AJM Wagenmakers, NEP Deutz, BK van Kreel, D Halliday, DE Matthews, PB Soeters & MF Von Meyenfeldt: Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate. Clin. Sci. 95: 339-346, 1998.

112. RK Johnson, RP Soultanakis & DE Matthews: Literacy and body fatness are associated with underreporting of energy intake in US low-income women using the multiple-pass 24-hour recall: A doubly labeled water study. J. Am. Diet. Assoc. 98: 1136-1140, 1998.

113. KM Ratheiser, DJ Brillon, RG Campbell & DE Matthews: Epinephrine produces a prolonged elevation in metabolic rate in humans. Am. J. Clin. Nutr. 68: 1046-1052, 1998.

114. RD Starling, DE Matthews, PA Ades & ET Poehlman: Assessment of physical activity in older individuals: A doubly labeled water study. J. Appl. Physiol. 86: 2090-2096, 1999.

115. A Tchernof, RD Starling, JD Walston, AR Shuldiner, RV Dvorak, K Silver, DE Matthews & ET Poehlman: Obesity-related phenotypes and the β3-adrenoceptor gene variant in postmenopausal women. Diabetes 48: 1425-1428, 1999.

116. E Svanberg, A-C Möller-Loswick, DE Matthews, U Körner, M Andersson & K Lundholm: The role of glucose, long-chain triglycerides and amino acids for promotion of amino acid balance across peripheral tissues in man. Clin. Physiol. 19: 311-320, 1999.

117. KM Ratheiser, GR Pesola, RG Campbell & DE Matthews: Epinephrine transiently increases amino acid disappearance to lower amino acid levels in humans. JPEN J. Parenter. Enteral Nutr. 23: 279-287, 1999.

118. A Battezzati, M Haisch, DJ Brillon & DE Matthews: Splanchnic utilization of enteral alanine in humans. Metabolism 48: 915-921, 1999.

119. DE Matthews, R Harkin, A Battezzati & DJ Brillon: Splanchnic bed utilization of enteral α -ketoisocaproate in humans. Metabolism 48: 1555-1563, 1999.

Matthews in CRC bed

Sept 2000: Dr. Matthews volunteers for his own tracer infusion study at UVM

120. JB Albu, M Curi, M Shur, L Murphy, DE Matthews & FX Pi-Sunyer: Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity. Am. J. Physiol. Endocrinol. Metab. 277: E551-E560, 1999.

121. MJ MacCoss, NK Fukagawa & DE Matthews: Measurement of homocysteine concentrations and stable isotope tracer enrichments in human plasma. Anal. Chem. 72: 4527-4533, 1999.

122. MJ Toth, A Tchernof, CJ Rosen, DE Matthews & ET Poehlman: Regulation of protein metabolism in middle-aged premenopausal women: Roles of adiposity and estradiol. J. Clin. Endocrinol. Metab. 85: 1382-1387, 2000.

123. M Haisch, NK Fukagawa & DE Matthews: Oxidation of glutamine by the splanchnic bed in humans. Am. J. Physiol. Endocrinol. Metab. 278: E593-E602, 2000.

124. D Gallagher, A Kovera, G Clay-Williams, D Agin, P Leone, J Albu, DE Matthews & SB Heymsfield: Weight loss in postmenopausal obesity: No adverse alterations in body composition and protein metabolism. Am. J. Physiol. Endocrinol. Metab. 279: E124-E131, 2000.

125. M Brochu, RD Starling, A Tchernof, DE Matthews, E García-Rubi & ET Poehlman: Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J. Clin. Endocrinol. Metab. 85: 2378-2384, 2000.

126. KM Tran, RK Johnson, RP Soultanakis & DE Matthews: In-person vs telephone-administered multiple-pass 24-hour recalls in women: validation with doubly labeled water. J. Am. Diet. Assoc. 100: 777-783, 2000.

127. SM Arpadi, PA Cuff, DP Kotler, J Wang, M Bamji, M Lange, RN Pierson & DE Matthews: Growth velocity, fat-free mass and energy intake are inversely related to viral load in HIV-infected children. J. Nutr. 130: 2498-2502, 2000.

128. LA Kotler, MJ Devlin, DE Matthews & BT Walsh: Total energy expenditure as measured by doubly labeled water in outpatients with bulimia nervosa. Int. J. Eat. Disord. 29: 470-476, 2001.

129. MJ Toth, ET Poehlman, DE Matthews, A Tchernof & MJ MacCoss: Effect of estradiol and progesterone on body composition, protein synthesis and lipoprotein lipase in rats. Am. J. Physiol. Endocrinol. Metab. 280: E496-E501, 2001.

130. MJ MacCoss, NK Fukagawa & DE Matthews: Measurement of intracellular sulfur amino acid metabolism in humans. Am. J. Physiol. Endocrinol. Metab. 280: E947-E955, 2001.

Matthews & Toth

March 2001: Drs. Matthews & Toth in conference at Sugarbush

131. MJ Toth, CK Sites, WT Cefalu, DE Matthews & ET Poehlman: Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women. Am. J. Physiol. Endocrinol. Metab. 281: E113-E121, 2001.

132. MJ Toth, MJ MacCoss, ET Poehlman & DE Matthews: Recovery of 13CO2 from infused [1-13C]leucine and [1,2-13C2]leucine in healthy humans. Am. J. Physiol. Endocrinol. Metab. 281: E233-E241, 2001.

133. MJ MacCoss, MJ Toth & DE Matthews: Evaluation and optimization of ion-current ratio measurements by selected-ion-monitoring mass spectrometry. Anal. Chem. 73: 2976-2984, 2001.

134. E Svanberg, A-C Möller-Loswick, DE Matthews, U Körner & K Lundholm: The effect of glutamine on protein balance and amino acid flux across arm and leg tissues in healthy volunteers. Clin. Physiol. 21: 478-489, 2001.

135. TS McIntosh, HM Davis & DE Matthews: A liquid chromatography-mass spectrometry method to measure stable isotopic tracer enrichments of glycerol and glucose in human serum. Anal. Biochem. 300: 163-169, 2002.

136. M Rosenbaum, EM Murphy, SB Heymsfield, DE Matthews & RL Leibel: Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J. Clin. Endocrinol. Metab. 87: 2391-2394, 2002.

137. SR Shinebarger, M Haisch & DE Matthews: Retention of carbon and alteration of expected 13C-tracer enrichments by silylated derivatives using continuous-flow combustion-isotope ratio mass spectrometry. Anal. Chem. 74: 6244-6251, 2002.

Matthews at Sugarbush

April 27, 2001: Still skiing in Vermont

138. R Persinger, Y Janssen-Heininger, SS Wing, DE Matthews, MM LeWinter & MJ Toth: Effect of heart failure on the regulation of skeletal muscle protein synthesis, breakdown, and apoptosis. Am. J. Physiol. Endocrinol. Metab. 284: E1001-E1008, 2003.

139. M Rosenbaum, K Vandenborne, R Goldsmith, JA Simoneau, S Heymsfield, DR Joanise, J Hirsch, E Murphy, D Matthews, KR Segal & RL Leibel: Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R183-R192, 2003.

140. A Battezzati, A Caumo, F Martino, LP Sereni, J Coppa, R Romito, M Ammatuna, E Regalia, DE Matthews, V Mazzaferro &L Luzi: Nonhepatic glucose production in humans. Am. J. Physiol. Endocrinol. Metab. 286: E129-E135, 2004.

141. CC Wu, MJ MacCoss, KE Howell, DE Matthews &JR Yates, III: Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal. Chem. 76: 4951-4959, 2004.

142. JA Henkin, ME Jennings, DE Matthews & JO Vigoreaux: Mass processing--an improved technique for protein identification with mass spectrometry data. J. Biomol. Tech. 15: 230-237, 2004.

143. MJ Toth, DE Matthews, RP Tracy & MJ Previs: Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am. J. Physiol. Endocrinol. Metab. 288: E883-E891, 2005.

144. MJ Toth, DE Matthews, PA Ades, MD Tischler, P Van Buren, MJ Previs & MM LeWinter: Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity. Am. J. Physiol. Endocrinol. Metab. 288: E685-E692, 2005.

145. DE Matthews: Observations of branched-chain amino acid administration in humans. J. Nutr. 135: 1580S-1584S, 2005.

146. MJ MacCoss & DE Matthews: Quantitative mass spectrometry for proteomics: Teaching a new dog old tricks. Anal. Chem. 77: 294A-302A, 2005.

147. ME Jennings, II & DE Matthews: Determination of complex isotopomer patterns in isotopically labeled compounds by mass spectrometry. Anal. Chem. 77: 6435-6444, 2005.

148. MJ MacCoss, CC Wu, DE Matthews & JR Yates, III: Measurement of the isotope enrichment of stable isotope-labeled proteins using high-resolution mass spectra of peptides. Anal. Chem. 77: 7646-7653, 2005.

Anal Chem Aug 2005 cover

August 1, 2005 cover of Analytical Chemistry

149. MJ Toth & DE Matthews: Whole-body protein metabolism in chronic heart failure: relationship to anabolic and catabolic hormones. JPEN J. Parenter. Enteral Nutr. 30: 194-201, 2006.

150. MJ Toth, CK Sites, DE Matthews & PR Casson: Ovarian suppression with gonadotropin-releasing hormone agonist reduces whole body protein metabolism in women. Am. J. Physiol. Endocrinol. Metab. 291: E483-E490, 2006.

151. MJ Toth, CK Sites & DE Matthews: Role of ovarian hormones in the regulation of protein metabolism in women: effects of menopausal status and hormone replacement therapy. Am. J. Physiol. Endocrinol. Metab. 291: E639-E646, 2006.

152. NL Reynaert, A van der Vliet, AS Guala, T McGovern, M Hristova, C Pantano, NH Heintz, J Heim, YS Ho, DE Matthews, EF Wouters & YM Janssen-Heininger: Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β. Proc. Natl. Acad. Sci. U. S. A. 103: 13086-13091, 2006.

153. J Martin, ZQ Wang, XH Zhang, D Wachtel, J Volaufova, DE Matthews & WT Cefalu: Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 29: 1826-1832, 2006.

154. DE Matthews: An overview of phenylalanine and tyrosine kinetics in humans. J. Nutr. 137: 1549S-1555S, 2007.

155. TM Thornton, G Pedraza-Alva, B Deng, CD Wood, A Aronshtam, JL Clements, G Sabio, RJ Davis, DE Matthews, B Doble & M Rincon: Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation. Science 320: 667-670, 2008.

156. SM McCarthy, PF Bove, DE Matthews, T Akaike & A van der Vliet: Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch. Biochemistry 47: 5832-5840, 2008.

157. MJ Previs, P VanBuren, KJ Begin, JO Vigoreaux, MM LeWinter & DE Matthews: Quantification of protein phosphorylation by liquid chromatography mass spectrometry. Anal. Chem. 80: 5864-5872, 2008.

158. Y Lamers, B O'Rourke, LR Gilbert, C Keeling, DE Matthews, PW Stacpoole & JF Gregory, III: Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women. Am. J. Clin. Nutr. 90: 336-343, 2009.

159. PC Echeverria, MJ Figueras, M Vogler, T Kriehuber, MN de, B Deng, MC Dalmasso, DE Matthews, M Matrajt, M Haslbeck, J Buchner & SO Angel: The Hsp90 co-chaperone p23 of Toxoplasma gondii: Identification, functional analysis and dynamic interactome determination. Mol. Biochem. Parasitol. 172: 129-140, 2010.

160. MJ Toth, MM LeWinter, PA Ades & DE Matthews: Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship with markers of immune activation. Clin. Sci. (Lond) 119: 467-476, 2010.

161. J Krudysz-Amblo, ME Jennings, DE Matthews, KG Mann & S Butenas: Differences in the fractional abundances of carbohydrates of natural and recombinant human tissue factor. Biochim. Biophys. Acta 1810: 398-405, 2011.

162. PC Spiess, B Deng, RJ Hondal, DE Matthews & A van der Vliet: Proteomic profiling of acrolein adducts in human lung epithelial cells. J. Proteomics 74: 2380-2394, 2011.

163. J Krudysz-Amblo, ME Jennings, T Knight, DE Matthews, KG Mann & S Butenas: Disulfide reduction abolishes tissue factor cofactor function. Biochim. Biophys. Acta 1830: 3489-3496, 2013.

164. L Holm, B O'Rourke, D Ebenstein, MJ Toth, R Bechshoeft, NH Holstein-Rathlou, M Kjaer & DE Matthews: Determination of steady state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans. Am. J. Physiol. Endocrinol. Metab. 308: E895-E907, 2013.

165. EJ Kasarskis, MS Mendiondo, DE Matthews, H Mitsumoto, R Tandan, Z Simmons, MB Bromberg & RJ Kryscio: Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis. Am. J. Clin. Nutr. 99: 792-803, 2014.

Last modified June 17 2015 11:44 AM