Clinical Neuroscience Research Unit
Personnel: Paul Newhouse
Paul Newhouse, M.D. Professor Emeritus
Dr. Newhouse's research has focused on central nicotinic mechanisms in degenerative brain disorders and the role of nicotinic receptor systems in normal and disordered cognitive functioning in humans. He has also focused attention on the development of novel nicotinic agents for clinical use. Other current research interests include the interaction of estrogen and central cholinergic systems in the elderly, treatment of depression and behavioral disturbances in the elderly, and development of effective novel agents for the treatment of neuropsychiatric disorders of the elderly.
Dr. Newhouse serves as a frequent consultant to a number of pharmaceutical and biotechnology companies in the United States and abroad on central nervous system drug development, clinical trial design for dementia and depression, and clinical nicotinic pharmacology. He has served on numerous NIH grant review committees, and is a frequent reviewer for scientific journals for manuscripts on depression, dementia and cognitive neuroscience. He is a diplomat of the National Board of Medical Examiners and the American Board of Psychiatry and Neurology in both General Psychiatry and Geriatric Psychiatry. He also maintains a busy teaching schedule and small clinical practice focused on neuropsychiatric diseases of the elderly.
Co-developer: Older Adult Self Report and Behavioral Check List. To order copies, go to http://www.aseba.org/.
Recent Publications
- Dumas, J.A., Kutz, A.M., Naylor, M.R., Johnson, J.V., & Newhouse, P.A. (2010). Increased memory load-related frontal activation after estradiol treatment in postmenopausal women. Hormones and Behavior, 58, 929-935. Download PDF
- Dumas, J.A., McDonald, B.C., Saykin, A.J., McAllister, T.W., West, J.D., Hynes, M.L., & Newhouse, P.A. (2010). Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: A pilot study. Menopause, 17(4), 852-859 Download PDF
- Newhouse, P.A., Dumas, J.A., Wilkins, H., Coderre, E., Sites, C., Naylor, M.R., Benkelfat, C., & Young, S.N. (2010). Estrogen treatment impairs cognitive performance following psychosocial stress and monoamine depletion in postmenopausal women. Menopause, 17(4), 860-873.
- Coderre, E., Filippi, C., Newhouse, P., & Dumas, J. (2009). Ichi, Ni, 3, 4: Neural representation of kana, kanji, and Arabic numbers in native Japanese speakers. Brain and Cognition, 70, 289-296. Download PDF
- Dumas, J, Saykin, A., McAllister, T., McDonald, B., Hynes, M., & Newhouse, P. (2008). Nicotinic versus muscarinic blockade alters verbal working memory performance and brain activation patterns in older women. American Journal of Geriatric Psychiatry, 16, 272-282. Download PDF
- Coderre, E., Filippi, C., Newhouse, P., & Dumas, J. (2008). The Stroop effect in kana and kanji scripts in native Japanese speakers: An fMRI study. Brain and Language, 107, 124-132. Download PDF
- Dumas, J., Hancur-Bucci, C., Naylor, M., Sites, C., & Newhouse, P. (2008). Estrogen interacts with the cholinergic system to affect verbal memory in post-menopausal women: Evidence for the critical period hypothesis. Hormones and Behavior, 53, 159-169. Download PDF
- Newhouse, P, Dumas, J., Hancur-Bucci, C., Naylor, M., Sites, C., Benkelfat, C., & Young, S. (2008). Estrogen administration negatively alters mood following monoaminergic depletion and psycho-social stress in post-menopausal women. Neuropsychopharmacology. 33, 1514-1527.
- Dumas, J., Hancur-Bucci, C., Naylor, M., Sites, C., & Newhouse, P. (2006). Estrogen treatment effects on anticholinerically-induced cognitive dysfunction in post-menopausal women. Neuropsychopharmaology, 31, 2056-2078. Download PDF
- Dumas, J., Edgren, C., & Newhouse, P. (2006). Estrogen therapy after menopause: Role in normal cognition and Alzheimer's disease. Aging Health, 2, 955-966
- Dumas, J., Salerno, J., & Newhouse, P. (2006). The role of estrogen in the development of age-related cognitive impairment and dementia. Psychiatric Times.
Last modified November 13 2011 11:30 AM
