"The Tortoise and the Hare: Finding the Targets of Selection in Genomes"
Dr. Andrew Kern
Assistant Professor, Dept. of Biological Sciences
December 7, 2009
Marsh Life Sciences 105
Among Kimura and Ohta's seminal "principles" of molecular evolution is the notion that functional constraint determines rate of evolution at the genetic level. Indeed this principle lies at the intellectual heart of the comparative genomics revolution of the past decade. I will demonstrate how computationally sophisticated methods can be integrated with mathematical results from population genetics and phylogenetics to identify those regions of genomes which are responsible for the myriad innovations in biological evolution.