College and School Ceremony Information
David Lyden, MD, PhD
Dr. Lyden was educated at the University of Vermont (PhD), Brown University (MD), Duke University (Residency) and Memorial Sloan-Kettering Cancer Center (Fellowship). Presently, he is the Stavros S. Niarchos Chair and Associate Professor of Pediatrics and Cell and Developmental Biology at Weill Cornell Medical Center and a Pediatric Neuro-Oncologist at Memorial Sloan-Kettering Cancer Center, and faculty member of the MD/PhD program at the Tri-Institute (Rockefeller University/Weill Cornell Medical College/Memorial Sloan Kettering Cancer Center). He is also a Foreign Investigator of the Champalimaud Foundation, first of its kind for the study of metastatic disease in Lisbon, Portugal. He has made several fundamental discoveries which involve the role of bone marrow-derived stem and progenitor cells in tumor vasculogenesis, or new blood vessel growth, and in metastasis, leading to several landmarks publications in the journals: Cell, Science, and Nature. In recent years, his team has shown evidence that secreted factors by the primary tumor prime distant tissue sites, known as the ‘pre-metastatic niche, supporting a favorable environment for future sites of metastasis. He has discovered that tumor-secreted microparticles, known as exosomes, package tumor protein and genetic information, travel in the bloodstream and fuse with cells in the bone marrow and at future sites of metastasis, promoting their education to a pro-metastatic cell. His work in tumor-derived exosomes has helped explain why cancer spreads to certain organs, known as organotropism, an observation proposed by physician Stephen Paget more than 120 years ago.
His honors and awards include: Distinguished Alumnus Brown University (2003) and the Leonard Weiss Memorial Lecturer Award (2007). His work was highlighted in “Nature Milestones: Cancer” (2005). In 2007, he was awarded a Presidential Medical Distinction Bial Award by President Cavaco Silva of Portugal. He is Co-Senior Editor for “Cancer Metastasis: Biologic Basis and Therapeutics”, the first cancer metastasis textbook focusing on research, prevention and treatment of metastatic disease, published by Cambridge University Press (April 2011). He has been featured as one of fifteen cancer experts in the book ‘Why Millions Survive Cancer: The Successes of Science” (author: Lauren Pecorino, Oxford Univ. Press). He is the recipient of the 2012 Inaugural I.J. “Josh” Fidler Innovation in Metastasis Research Award, given by the Metastasis Research Society and Anti-Cancer Inc., in Brisbane, Australia. Notably, Dr. Lyden is the 2012 University of Vermont College of Medicine’s Distinguished Alumni Awardee.
Last modified March 18 2013 12:46 PM