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College of Arts and Sciences

Department of Chemistry

UVM Chemistry Research: Stephen Waters

Stephen P. Waters

Stephen Waters

Stephen P. Waters, Ph.D., Assistant Professor of Chemistry

  • Ph.D., University of Pennsylvania, 2004
  • postdoctoral fellowship, Memorial Sloan-Kettering Cancer Center in New York, 2004-2007
  • Assistant Professor of Chemistry, University of Vermont, 2007
  • Curriculum vitae
Area of expertise

organic chemistry, synthetic methods, total synthesis, natural products

Contact Information

Email: Stephen.Waters@uvm.edu

Phone: (802) 656-0274

Office: Cook Rm A321

Research

The mission of my laboratory is to address new challenges in organic chemistry through contributions to the areas of synthetic strategy and methods development. Attention is given to the synthesis of natural products with potential therapeutic value.

The challenges associated with total synthesis test the limits of our analytical and technical skills, providing a vehicle through which the broader field of organic chemistry is advanced. While Nature continues to yield an array of structurally diverse compounds, our research endeavors will target those compounds that foster innovative synthetic design. When possible, we seek the biosynthetic origins of these targets to guide our efforts. Our particular interests are founded in strategies for the construction of nitrogen-containing heterocyclic systems - a motif common to both naturally occurring alkaloids and a large number of pharmaceutical commodities.

High priority is given to natural products whose profiles invite new opportunities for collaborative, interdisciplinary studies with specialists equipped to advance the program beyond the level of chemical synthesis. The long-term goal of the program is the identification of those compounds best suited for candidacy into advanced biological settings.

Waters targets

Selected Publications

Cheng, X.; Waters, S. P. “Concise Total Syntheses of the Lycopodium Alkaloids (±)-Nankakurines A and B via Luciduline” Org. Lett. 2010, 12, 205-207.

Panarese, J. D.; Waters, S. P. “Enantioselective Formal Total Synthesis of (+)-Aspergillide C” Org. Lett. 2009, 11, 5086-5088.

McCormack, M. P.; Shalumova, T.; Tanski, J. M.; Waters, S. P. “Development of a 2-Aza-Cope-[3+2] Dipolar Cycloaddition Strategy for the Synthesis of Quaternary Proline Scaffolds Org. Lett. 2010, 12, 3906-3909.

Angeles, A. R.; Waters, S. P.; Danishefsky, S. J. “Total Syntheses of (+)-and (–)-Peribysin E” J. Am. Chem. Soc. 2008, 130, 13765-13770.

Waters, S. P.; Fennie, M. W.; Kozlowski, M. C. "Investigation of a Convergent Route to Purpuromycin: Benzofuran Formation vs. Spiroketalization" Org. Lett. 2006, 8, 3243-3246.

Waters, S. P.; Fennie, M. W.; Kozlowski, M. C. "Convergent Route to the Purpuromycin Bisphenolic Spiroketal: Hydrogen Bonding Control of Spiroketalization Stereochemistry" Tetrahedron Lett. 2006, 47, 5409-5413.

Waters, S. P.; Tian, Y.; Li, Y-M.; Danishefsky, S. J. "Total Synthesis of (-)-Scabronine G, an Inducer of Neurotrophic Factor Production" J. Am. Chem. Soc. 2005, 127, 13514-13515.

Last modified May 04 2012 09:20 AM

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