Department of Chemistry
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A. Paul Krapcho, Ph.D., Emeritus Professor of Chemistry, was inducted as a Fellow into the Vermont Academy of the Arts and Sciences
Volume 81 of Organic Reactions by Wiley is dedicated to the Krapcho Reaction, honoring Emeritus Prof. A. Paul Krapcho
From the Wiley website:
Volume 81 represents the confluence of two rare and important phenomena for chapters in the Organic Reactions series, namely, it is a single-chapter volume, and it contains a name reaction coauthored by the inventor. Of the 261 chapters published thus far, only seven have been of sufficient impact to appear as single-chapter volumes. The single chapter in this volume entitled "The Krapcho Dealkoxycarbonylation Reaction of Esters with a-Electron-Withdrawing Substituents" has been coauthored by A. Paul Krapcho together with Organic Reactions' long-time contributor Engelbert Ciganek. The "Krapcho Decarboxylation," as it is known in common parlance, is an extraordinarily useful alternative to the classical hydrolysis-decarboxylation of esters bearing a-electron-withdrawing substituents. This process replaces the strongly basic or acidic conditions normally required for ester saponification with the neutral cleavage of the ester group by a BAC2 mechanism through the combination of water and a dipolar aprotic solvent at high temperature. However, another popular variant involves the use of inorganic salts such as lithium chloride, sodium iodide, or sodium cyanide in a dipolar aprotic solvent which can open a second mechanistic pathway (dependent upon the ester) through BAL2 cleavage. Drs. Krapcho and Ciganek expertly outline the broad substrate scope of this reaction and identify the preferred conditions for various substrate classes. The 371 pages of tables containing all known examples of this simple but important transformation, together with the 1,908 references cited in this Chapter, are testimony to the synthetic usefulness of the Krapcho reaction.
(Photo by Sally McCay)
Evan M. Sherbrook and Erik H. Horak receive the Department of Chemistry Senior Awards for 2013
Shown in the photo are Prof. Christopher Landry, Evan Sherbrook, Erik Horak and Prof. & Chair Dwight Matthews at the UVM College of Arts & Sciences Honors Day on May 17, 2013 where Evan & Erik received their awards.
Evan M. Sherbrook was awarded the American Chemical Society Green Mountain Section Award, and Erik Horak received the Charles E. Braun Award.
The American Chemical Society Green Mountain Section Award is given to an outstanding senior chemistry major for academic performance in chemistry. The Braun Award is given to an outstanding senior chemistry major for performance of research in chemistry in memory of Charles Braun, former Department Chair and the first Dean of the Graduate College.
Evan will be in the Department of Chemistry at the University of Wisconsin (Madison) this fall beginning work on his Ph.D. in chemistry. Erik will remain at UVM this year working in the Department of Chemistry as a teaching assistant to undergraduate student laboratories and doing research with Prof. Liptak while his fiancé finishes an MS in statistics at UVM.
Evan M. Sherbrook was awarded the Hannah Howard Prize at the 2013 College of Arts & Sciences Honors Day
The Hannah Howard Prize is annually awarded to the College of Arts & Sciences undergraduate student with the highest cumulative grade point in the College. Often the award goes to a student with a perfect 4.0 grade point (note: grades of "A+" are recorded as 4 grade points – the same as for an "A"). This year there was a second awardee whose grade point tied Evan's: Georgia Jewett, a political science major. See the news story.
Evan Sherbrook is a native Vermonter who graduated from Lyndon Institute, an independent high school and boarding school located in the village of Lyndon Center, in the town of Lyndon, Vermont. In Evan's sophomore year at UVM, he took organic chemistry. Although he was excited about chemistry before, Evan could not stop talking about organic chemistry. Evan received the Chemistry Department's sophomore award for excellence in the study of organic chemistry. He also received the department's third-year Merck Index award and the fourth-year award, the American Chemical Society Green Mountain Section Award, for outstanding performance both in academic study and in research.
Evan has taken a range of courses at UVM, and as evidenced by the Hannah Howard Prize, he has excelled in all. However, his love and enthusiasm for chemistry rises above all. Not only has he completed the undergraduate curriculum coursework, but he has also finished most of the coursework that graduate students take in chemistry. Evan also did research in organic chemistry during the academic year as well as during the summer. His research advisor, Professor Stephen Waters, commented that, compared to other students, Evan displayed an uncommonly strong discipline, personal motivation, and drive for both research and academic studies.
Evan will pursue a Ph.D. degree in Chemistry at the University of Wisconsin for his graduate studies in organic chemistry this fall.
Graduate Students in Chemistry Organize a One-Day Chemistry Camp for Kids
On Saturday April 13, 2013 sixty elementary-age school children came to the Cook Physical Sciences Building for a one day experience in chemistry, themed "the Chemistry of Foods." Students, ranging from kindergarten to 5th grade, were divided into 4 age-related groups of 15 kids each for a day of fun and experimentation beginning at 9 am that morning. They participated in 3 laboratory experiments in the morning, then ate a bag lunch that was generously provided by the Bluebird Tavern, and participated in 2 more laboratory experiments in the afternoon. The experiments ranged from making and working with oobleck, a type of non-Newtonian fluid (everyone's hand's on favorite when colored dyes are involved), to making a battery out of a potato. Each laboratory experiment was taught by two Chemistry graduate students, and each group of students was lead by one graduate student team leader. At the end of the day the participants went to our main auditorium for a chemistry demonstration including explosions, fire and working with liquid nitrogen to round out the spectrum of hot to cold. Most of the student's parents also came for the demonstration. Although a number of Chemistry graduate students participated in the event, special recognition goes to Ms. Karla Erickson and Natalie Machamer who developed, organized and directed the event. Acknowledgements are also made to the generous funding provided by UVM's Department of Chemistry and the Food Systems program. Funds raised from this event will go to defraying costs of Chemistry graduate students to attend national conferences in chemistry. The event was so successful that our graduate students are already planning the 2014 event.
Photographs by Xiaoxi Liu
Professor Christopher Landry named University Scholar for 2013-14
Each year, up to four distinguished faculty members (two from the basic and applied sciences, and two from the social sciences and humanities) are named University Scholars by the Graduate College in recognition of their sustained excellence in research and scholarly activities. University Scholars are selected by a panel of faculty scholars, based upon nominations submitted by UVM faculty.
Prof. Landry arrived at UVM as an Assistant Professor in 1996 and was appointed full Professor in 2007. He has held a visiting faculty appointment in chemistry and chemical biology at Harvard, and has been the recipient of a Fulbright Senior Research Fellow Award.
Professor Landry’s initial research was in the discovery and development of porous materials. For many years, he has been creating new methods for the catalytic decontamination of chemical weapons, pesticides, and other environmental contaminants using porous materials. More recently, he has extended these studies into biomedical research, working with colleagues at UVM to develop new nanomaterials for in vivo drug delivery. His research funding has included a prestigious CAREER award from the National Science Foundation, as well as funding from the Department of Defense and Army Research Office, the National Institutes of Health, and companies. Landry’s work has resulted in numerous publications in leading professional journals and three US patents. He is frequently invited to speak at universities, laboratories, and professional meetings.
Strongly interested in interdisciplinary programs and research, he was central to the development of the cross-college undergraduate major in biochemistry, and also holds membership in the interdisciplinary graduate programs in Materials Science and Cellular, Molecular & Biomedical Sciences. Landry has been the research mentor to eight post-doctoral employees, thirteen doctoral students, and numerous undergraduates.
Landry’s many service contributions include, at UVM, co-chairing the University’s re-accreditation, President of the Phi Beta Kappa chapter, and Graduate College Executive Committee member; and externally, grant review panels for the National Institutes of Health, NSF, and the Department of Defense, as well as manuscript review for a variety of journals.
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Last modified October 23 2013 07:34 AM