I graduated from WPI in Feb 2008 with a B.S. in biology before moving on to Mass Biologics where I participated in the development of mutant SOD1 Abs. After that I proceeded to Alnylam where my research focused on the utilization of siRNA to enhance the production of desired cell products.
I am currently examining the possible functional homology between vertebrate cardiac Myosin Binding Protein-C (cMyBP-C) and invertebrate flightin (FLN) and have utilized atomic force microscopy (AFM) and transmission electron microscopy (TEM) to evaluate thick filament persistence length and sarcomere structure in the indirect flight muscle (IFM) transgenic D. melanogaster models expressing cMyBP-C with and without FLN. I am also examining localization and characterizing binding kinetics of these proteins in the IFM.
Other interests include biomimetics and biomaterials, specifically employing alpha-helical coiled-coils such as that found in the light meromyosin (LMM) region of myosin II thick filaments.