Signal transduction, proteomics, neuroscience
Office Hours: Wednesdays, 9:30-11:30
Marsh Life Science Building, Rm 311
Phone: (802) 656-1389
Website: Ballif Lab
Research in the Ballif lab is primarily focused on elucidating molecular mechanisms of signal transduction with two majoremphases: (A) genetically-defined signaling pathways regulating vertebrate brain development and (B) core signalingpathways regulating cell proliferation, growth andsurvival. In addition to biochemical and cell biological approaches, we employ mass spectrometry-based proteomics as a primary tool to identify and quantitatively monitor proteins, their modifications and their interactions with other proteins following acute signal administration or across developmental stages. We are also using zebrafish, drawing on the expertise of our sister lab headed by Alicia Ebert, as an organismalmodel system to study signaling pathways regulatingdevelopment, particularly neuronal positioning.
A second focus of our work involves developing and applying proteomic methodology to advance diverse lines of biological inquiry, some of which have had little to no interface with proteomics. This makes these projects both exciting and challenging. These collaborative projects range from the identification of novel human blood group antigens; to the identification of host proteins that interact with arenavirus proteins; to targeted proteomic characterizations of wasps, pitcher plant ecosystems, ants, fruit flies, unicellular ciliates and parasitic protozoa.
Proteomic and Signaling Studies of the Brain or Cell Migration
Signaling Studies in Cell Survival / DNA Damage / Cell Growth and Proliferation
Protein / Proteomic Studies in Immunobiology / Transfusion Science
Proteomic / Protein / Phylogenetic Studies in Evolution and Ecology
Additional Diverse Proteomic / Protein Studies