University of Vermont

The College of Arts and Sciences

Department of Biology

Faculty - Jim O. Vigoreaux


Jim O. Vigoreaux, Professor, Associate Provost

  • Ph.D., University of Oklahoma Health Science Center, 1987
  • Research Associate (1987-1991) Massachusetts Institute of Technology
  • Assistant Professor (1991-1996), Associate Professor (1997-2004), University of Vermont
  • Professor and Chair (2005-2015) University of Vermont
  • Professor and Associate Provost (2015-present) University of Vermont
Area of expertise

muscle biology

Contact Information
Email: Jim Vigoreaux

Office Hours: By appointment

Room 347A Waterman Building
Phone: (802) 656-4627

Visit Dr. Vigoreaux's Lab

Provost Office


The Vigoreaux lab is interested in the structural and functional properties of muscles that power oscillatory systems, namely the insect flight muscle and the vertebrate cardiac muscle. We use classical and molecular genetic approaches to study the function of various contractile proteins of the indirect flight muscles (IFM) of Drosophila melanogaster. Our goal is to understand how individual proteins contribute to the structural stability and mechanical properties of the muscle fiber, and to the function of the flight system. This research combines biochemical techniques to analyze protein function, cell imaging techniques to analyze muscle ultrastructure, bioengineering techniques to analyze muscle mechanical properties, and entire flight system measurements. See LAB webpage for more details on current projects.

Selected Publications


  • Tanner, B.C. W., Miller, M. S., Miller, B. M., Lekkas, P., Irving, T. C., Maughan, D. W . and Vigoreaux, J. O. (2011) COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.
  • Miller, M.S., P. Lekkas, J. M. Braddock, G. P. Farman, B. Ballif, T. C. Irving, D. W. Maughan, and J. O. Vigoreaux (2008) Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophys. J. 95:2391-2401. TEXT
  • Barton, B, Ayer, G., Maughan, D. W., and Vigoreaux, J. O. (2007) Site Directed Mutagenesis of Drosophila Flightin Disrupts Phosphorylation and Impairs Flight Muscle Structure and Mechanics. J. Muscle Res Cell Motil, 28: 219-230. TEXT
  • Barton, B., Ayer, G., Heymann, G. Maughan, D. Lehmann, F., and Vigoreaux, J. O. (2005) Flight muscle properties and aerodynamic performance of Drosophila expressing a flightin transgene. J. Exp. Biol., 208: 549-560.
  • Henkin, J., Maughan, D. W. and Vigoreaux, J. O. (2004) Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers. Amer. J. Physiol., Cell Physiol., 286: C65-C72. TEXT


  • Carlson, B.A., Vigoreaux, J.O., and Maughan, D.W. (2014) Diffusion rates of endogenous cytosolic proteins from rabbit skinned muscle fibers. Biophys. J. 106(4), 780-792. TEXT
  • Vishnudas, V., Guillemette, S., Lekkas, P., Maughan, D., and Vigoreuax, J.O. (2013) Characterization of intracellular distribution of an adenine nucleotide transporter (ANT) in Drosophila indirect flight muscles. CellBio, 2, 149-162. TEXT
  • Vishnudas, V. and Vigoreaux, J. (2006) Achieving sustained performance: possible strategies for coordinating energetic supply and demand, in Nature's Versatile Engine: Insect Flight Muscle Inside and Out, Vigoreaux, J. editor, Springer/Landes Bioscience, New York/Georgetown. pp 188-196.
  • Maughan, D. Henkin, J., and Vigoreaux, J. (2005) Concentrations of glycolytic enzymes and other cytosolic proteins in the diffusible fraction of a vertebrate muscle proteome. Mol. Cell Proteomics 4.10: 1541-1549.


  • Menard L., Nyland, L and Vigoreaux, J.O. (2013) The Structural and Biomechanical Properties of Insect Thick Filaments Expressing Flightin and Cardiac Myosin Binding Protein-C. Microscopy & Microanalysis. 19(S2), 80-81.
  • Miller, M.S., Tanner, B. C. W., Nyland, L., and Vigoreaux J. O. (2010) Comparative biomechanics of thick filaments and thin filaments with functional consequences for muscle contraction. (Invited review) J. Biomed & Biotech., Vol 2010, Article ID 473423, 14 pages, TEXT
  • Contompasis, J., Nyland, L., Maughan, D. and Vigoreaux, J. O. (2010) Flightin is necessary for length determination, structural integrity and large bending stiffness of insect flight muscle thick filaments. J. Mol. Biol, 395: 340-348.
  • Nyland, L. R., Palmer, B. P., Chen, Z., Maughan, D. W., Seidman, C. E., Seidman, J. G., Kreplak, L., and Vigoreaux, J. O. (2009) Cardiac myosin binding protein-C is essential for thick filament stability and flexural rigidity. Biophys. J., 96: 3273-3280. TEXT
  • Kreplak, L., Nyland, L., Contompasis, J. L., and Vigoreaux, J. O. (2009) Nanomechanics of native thick filaments from indirect flight muscles. J. Mol. Biol., 386: 1403-1410.


  • Soto-Adames. F., Alvarez-Ortiz, P., Vigoreaux, J.O. (2014) An Evolutionary Analysis of Flightin Reveals a Conserved Motif Unique and Widespread in Pancrustacea. J.Mol.Evol. 78, 24-37. TEXT


  • Chakravorty, S., Vu, H, Foelber, V., and Vigoreaux, J.O. (2014) Mutations of the Drosophila Myosin Regulatory Light Chain Affect Courtship Song and Reduce Reproductive Success. PLOS One. TEXT
  • Chakravorty, S. Wadja, M. and Vigoreaux, J. O. (2012) Analysis of mating song in Drosophila muscle mutants. (Invited chapter) In Methods, 56: 87-94. Benian, G. and Bernsteins, S., editors. Elsevier Journals Publishing.


  • Nature's Versatile Engine, Insect Flight Muscle Inside and Out, Vigoreaux, J. editor, Springer/Landes Bioscience, New York/Georgetown, 2006.
  • Chakravorty, S. and Vigoreaux, J. O. (2010) Amplification of orthologous genes using degenerate primers (Invited chapter). In vitro Mutagenesis Protocols. Third Edition. Braman, J., editor. Humana Press, pp 175-185.
  • Vigoreaux, J. (2006) Molecular basis of muscle structure, in Muscle Development in Drosophila, H. Sink, editor. Springer/Landes Bioscience, New York/Georgetown. pp 143-156. TEXT
  • Maughan, D. and Vigoreaux, J. (2005) Nature's strategy for optimizing power generation in insect flight muscle, in Mysteries about the sliding filament mechanism: Fifty years after its proposal, Sugi, H, editor. Kluwer Press. TEXT
  • Swank, D. and Vigoreaux, J. O. (2004) The Development of the Flight and Leg Muscle. In Comprehensive Molecular Insect Science. Volume 2, 45-84. Gilbert, L.I., Iatrou, K., and Gill, S. editors. Elsevier, Oxford. LINK
  • Vigoreaux, J. O. (2001) Genetics of the Drosophila flight muscle myofibril: A window into the biology of complex systems (Invited review). BioEssays 23: 1047-1063. TEXT
  • Vigoreaux, J. O., Moore, J. R., and Maughan, D. W. (2000) Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. In "Elastic filaments of the Cell". Pollack, G. and Granzier, H., editors. Kluwer Academic/Plenum Publishers. pp 237-250
  • Maughan, D. W. and Vigoreaux, J. O. (1999) An integrative view of insect flight muscle: genes, motor molecules and motion. News In Physiol. Science. 14, 87-92.