University of Vermont

UVM Innovations

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

Karen Lounsbury, PhD and Chris Francklyn, PhD have found the eznyme threonyl-tRNA synthetase (TARS) is involved in regulating angiogenesis and gets activated in certain cancers at specific points in its progression. Graduate student, Tamara Williams, PhD, is the lead author. Compounds that reduce TARS could be used to stop angiogenesis, compounds that increase this enzyme would promote angiogenesis and an assay for it might be a diagnostic for progression of certain cancers. full story