Dr. Christopher Steward Francklyn

Dr. Christopher Steward Francklyn


Protein synthesis in biological regulation and human disease

My lab investigates the relationship between protein synthesis enzymes, biological regulation, and complex human diseases. We have a particular focus on the enzymes that interact with transfer RNAs in cells, and have made many fundamental contributions to their basic mechanism and tRNA recognition properties. More recently, we have moved deeper in the clinical/translational realm, exploring the specific relationship of these enzymes to a variety of human diseases, including cancer, peripheral neuropathies, autoimmune diseases, and infectious diseases. We and our collaborators employ a broad range of techniques, including classical and physical biochemistry, cell biology, developmental biology, and even techniques in clinical research. We have many local collaborators at UVM, including Karen Lounsbury and Alan Howe (Pharmacology), Jon Ramsey (VCC Translation Lab), Alicia Ebert (Biology), Jason Bates (Medicine), and Mark Plante (Surgery). We also interact with other labs in the United States, Europe and Asia. Dr. Francklyn is also a frequent consultant for biotechnology companies.

B401 Given

Given B403


Chris received his Ph.D from the University of California at Santa Barbara in 1988. From 1989-1991, he carried out postdoctoral studies with Paul Schimmel, then at M.I.T. He joined the University of Vermont in 1991. He is currently Professor in the Department of Biochemistry, and Adjunct Professor in the Department of Microbiology and Molecular Genetics.


Francklyn, C. & Schimmel, P. (1989) Aminoacylation of RNA Minihelices with Alanine. Nature 337: 478-481.

Francklyn, C., Shi, J. P., & Schimmel, P. (1992) Overlapping Nucleotide Determinants for Specific Aminoacylation of RNA Microhelices with Three Different Amino Acids. Science. 255:1121-1125.

Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA. (2012) PLoS One. 2012;7(1):e28936. Epub 2012 Jan 17.

Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam Mirando, Kaige Chen, Xin Chen, Sunghoon Kim, Christopher S. Francklyn, Min Guo (2014) Structural Basis for Full-Spectrum Inhibition of Translational Functions on a tRNA synthetase. Nat Commun. 2015 Mar 31;6:6402. doi: 10.1038/ncomms7402.

Mirando, A. C., Fang, P., Williams, T. F., Baldor, L.C., Howe, A. K., Ebert, A. M., Wilkinson, B., Lounsbury, K. M., Guo, M., and Francklyn, C.S. (2015) Regulation of aminoacyl-tRNA synthetase dependent angiogenesis by a bioengineered macrolide inhibitor. Sci Rep. 2015 Aug 14;5:13160. doi: 10.1038/srep13160.

All Francklyn publications