Dr. Dawei Li
Human Genetics and Genomics
Genomics: Future of Medicine
Research in our laboratory aims to understand the genetic basis of these genomic variations and their roles in the etiologies of complex human diseases, particularly mental disorders and brain diseases (e.g., substance use disorders), using the latest high-throughput genomic platforms (e.g., microarrays and next-generation sequencing) and advanced computational tools, followed by functional validations of identified variants. Our studies will provide better understanding of the disease mechanisms towards novel development of early diagnosis, disease prediction, and personalized treatment.
Typical Research Design
Current Research Topics
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214A Stafford Hall
Li D, Zhao H, Kranzler HR, Oslin D, Anton RF, Farrer LA, Gelernter J. Association of COL25A1 with comorbid antisocial personality disorder and substance dependence. Biol Psychiatry. 2012 Apr 15;71(8):733-40.
Li D, Zhao H, Gelernter J. Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. Hum Genet. 2012 Aug;131(8):1361-74. Epub 2012 Apr 5.
Li D, Zhao H, Gelernter J. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Hum Genet. 2012 May;131(5):725-37.
Li D, Zhao H, Gelernter J. Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry. 2011 Sep 15;70(6):504-12.
Li D, He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry. 2007 Jan;12(1):47-54.