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Myosin Binding Protein C in Skeletal Muscle

Striated muscle expresses three isoforms of myosin binding protein C (MyBP-C) that are critical regulators of contractility. Cardiac MyBP-C behaves as a molecular break or gas-pedal under distinct physiological conditions, and disruptions to these processes leads to disease. While its role in cardiac muscle has been extensively investigated, our understanding of what MyBP-C does in skeletal muscle remains unclear. Of particular interest is the recent discovery that a sub-set of muscular dystrophy patients carry mutations in skeletal MyBP-C. My research aims to characterize the expression, localization and function of skeletal MyBP-C using a compliment of biochemical and biophysical approaches.

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BACKGROUND

Amy Li studied Physiology and Psychology at the University of Sydney, where she received her BSc (Hons 1) in the Discipline of Anatomy & Histology in 2011. In 2016 she defended her thesis on the mechanical properties of diseased heart tissue from cardiomyopathy patients carrying mutations of the sarcomere. In 2016, she also moved to the University of Vermont as a post-doctoral fellow to examine the role of skeletal myosin binding protein C.

LAB MEMBERS

Ramiro Barrantes-Reynolds
        Research Specialist
Helen Brunelle
        Program Assistant
Vy Cao
        Research Technician
Brittany Carroll
        Graduate Student
Dan Cotnoir
        Research Technician
David Danforth
        Research Technician
Barbara Drapelick
        Departmental Administrator
Philip Eisenhauer
        Senior Research Technician
Erika English
        Research Technician
Maria Espinoza
        Research Technician
Stephen Edward Feehan
        N/A
Eleanor Fortner-Buczala
        Undergraduate Student
Nancy Graham
        Research Technician
Scott Kathe
        Researcher/Analyst
Anne Kelsen
        Research Technician
Jason Kost
        Research Specialist
Melissa Latshaw
        Research Technician
Anne MacLeod
        Program Assistant
Ben McElvany
        Research Technician
Marcella Melloni
        Research Technician
Forida Nazib
        Research Technician
Kristin Schutz
        Research Technician
Eli Sendra
        Research Technician
Dave Shirley
        Research Specialist
Marni Slavik
        Research Specialist
Archana Vaithilingam
        Graduate Student
Kirstin van Luling
        Administrative Assistant

SELECTED PUBLICATIONS

Binbrek, A., Mittal, B., Rao, K., and Sobel, B. The potential of erythropoietin for conferring cardioprotection complementing reperfusion. Coron Artery Dis 2007;18:583-585

Binbrek, A., Mittal, B., Rao, K., and Sobel, B. The potential of erythropoietin for conferring cardioprotection complementing reperfusion. Coron Artery Dis 2007;18:583-585

Binbrek, A., Mittal, B., Rao, K., and Sobel, B. The potential of erythropoietin for conferring cardioprotection complementing reperfusion. Coron Artery Dis 2007;18:583-585

Binbrek, A., Mittal, B., Rao, K., and Sobel, B. The potential of erythropoietin for conferring cardioprotection complementing reperfusion. Coron Artery Dis 2007;18:583-585

Bouchard, B., Paradis, A., and Brummel-Ziedins, K. Measurement of procoagulant platelet subpopulations in whole blood: development of an assay for population-based studies. Thromb Res. 2011 Jan;127(1):62-4. Epub 2010 Jun 11.