Archive for Research

Research Spotlight: The impact of chromatin on DNA repair complex assembly and function

Citation: Odell, I.D., Barbour, J.E., Murphy, D.L., Della-Maria, J.A., Sweasy, J.B., Tomkinson, A.E., Wallace, S.S., Pederson, D.S. 2011. Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair. Mol Cell Biol. 31(22):4623-32 Direct link to publication Authors Associated with MMG: Ian Odell – recently earned his Ph.D. in MMG. At present, Ian is finishing [...]

Research Spotlight: A Toxoplasma gondii protein important for cell shape and virulence

Citation: Barkhuff, W.D., Gilk, S.D., Whitmarsh, R., Tilley, L.D., Hunter, C., Ward, G.E. 2011. Targeted disruption of TgPhIL1 in Toxoplasma gondii results in altered parasite morphology and fitness. PLoS One. 6(8):e23977. Direct link to publication Authors Associated with MMG: Whittney Dotzler Barkhuff – was an MD/PhD student in the CMB program Stacey Gilk – was [...]

Research spotlight: Small molecule inhibitors of bacterial choline catabolism

Citation: Fitzsimmons, L.F., Flemer, S. Jr, Wurthmann, A.S., Deker, P.B., Sarkar, I.N., Wargo, M.J. 2011. Small-Molecule Inhibition of Choline Catabolism in Pseudomonas aeruginosa and Other Aerobic Choline-Catabolizing Bacteria. Appl Environ Microbiol. 77(13):4383-4389. Direct link to publication Authors Associated with MMG: Liam F. Fitzsimmons – is a Research Technician in MMG I. Neil Sarkar – is [...]

Research Spotlight: Structural understanding of viral polymerase inhibition by phosphonoformic acid

Citation: Zahn, K.E., Tchesnokov, E.P., Götte, M., and Doublié S. 2010. Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase. J Biol Chem. 286:25246-25255. Direct Link to Publication Authors’ Associations: Karl E. Zahn – is a graduate student in the CMB program Sylvie Doublié – is a Professor in the [...]

Research Spotlight: Insights into glmS ribozyme catalysis

Citation: Brooks KM and Hampel KJ. 2011. Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements. Biochemistry 50(13):2424-2433 Direct Link to Publication Authors’ Association with MMG: Krista Brooks – is a recent MMG graduate student now a postdoc at Scripps Ken Hampel – is an Assistant Professor in the MMG Department Summary: [...]

Research Spotlight: Insights into Toxoplasma gondii Differentiation

Citation: Lescault PJ, Thompson AB, Patil V, Lirussi D, Burton A, Margarit J, Bond J, Matrajt M. 2010. Genomic data reveal Toxoplasma gondii differentiation mutants are also impaired with respect to switching into a novel extracellular tachyzoite state. PLoS One. 2010 Dec 30;5(12):e14463. Direct link to publication Authors’ Association with MMG: Pam Lescault – is [...]

Research Spotlight: Mechanism for 25 kDa subunit of human cleavage factor Im recognition of UGUA RNA sequence element

Citation: Yang Q, Gilmartin GM, and Doublié S. 2010. Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3’ processing. Proc Natl Acad Sci, 107, 10062-7. Direct link to the publication at the PNAS website Authors’ Association with MMG: Qin Yang – is a graduate student [...]

Research Spotlight: Mechanism for Ogg2 DNA glycosylase recognition of the damaged base, 8-oxoguanine

Citation: Faucher F, Wallace SS, and Doublié S. 2010. The C-terminal lysine of Ogg2 DNA glycosylases is a major molecular determinant for guanine/8-oxoguanine distinction. Journal of Molecular Biology 397(1):46-56. Link to the article in PubMed Authors’ Association with MMG: Frédérick Faucher – was a postdoctoral associate in the MMG Department Sylvie Doublié – is a [...]

Research Spotlight: Inhibition of Toxoplasma Motility

Citation: Heaslip AT, Leung JM, Carey KL, Catti F, Warshaw DM, Westwood NJ, Ballif BA, Ward GE. 2010. A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity. PLoS Pathog. 6(1):e1000720. Authors’ Association with MMG: Aoife T. Heaslip – received her Ph.D. from the MMG [...]

COBRE Seminar: Megan Shaw, Ph.D. “Human host factors required for influenza virus replication”

At 10am on Friday, January 8th in HSRF 400, Dr. Shaw, Assistant Professor of Microbiology Mount Sinai School of Medicine, will give a seminar highlighting her latest work on the host factors necessary for influenza viral replication, the focus of a recent letter to Nature (article PMID 20027183).