Selected Publications

  1. Johnson, D. I., C. W. Jacobs, J. R. Pringle, L. C. Robinson, G. F. Carle, and M. V. Olson. 1987. Mapping of the Saccharomyces cerevisiae CDC3, CDC25, and CDC42 genes to chromosome XII by chromosome blotting and tetrad analysis. Yeast 3:243-253.
  2. Adams, A. E. M., D. I. Johnson, R. M. Longnecker, B. F. Sloat, and J. R. Pringle. 1990. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell Biol. 111:131-142.
  3. Johnson, D. I., and J. R. Pringle. 1990. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J. Cell Biol. 111:143-152.
  4. Johnson, D. I., J. M. O'Brien, and C. W. Jacobs. 1990. Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae. Gene 90: 93-98. Corrigendum Gene 98:149-150.
  5. Shinjo, K., J. G. Koland, M. J. Hart, V. Narasimhan, D. I. Johnson, T. Evans, and R. A. Cerione. 1990. Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): Identification of this GTP-binding protein as the human homolog of the yeast cell-division cycle protein CDC42. Proc. Natl. Acad. Sci. USA 87:9853-9857.
  6. Finegold, A. A., D. I. Johnson, C. C. Farnsworth, M. H. Gelb, J. A. Glomset, and F. Tamanoi. 1991. Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product. Proc. Natl. Acad. Sci. USA 88:4448-4452.
  7. Ziman, M., J. M. O'Brien, L. A. Ouellette, W. R. Church, and D. I. Johnson. 1991. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. Mol. Cell. Biol. 11:3537-3544.
  8. Ziman, M., D. Preuss, J. Mulholland, J. M. O'Brien, D. Botstein, and D. I. Johnson. 1993. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol. Biol. Cell 4:1307-1316.
  9. Miller, P., and D. I. Johnson. 1994. Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe. Mol. Cell. Biol. 14:1075-1083.
  10. Ziman, M., and D. I. Johnson. 1994. Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42. Yeast 10:463-474.
  11. Posada, J, P. J. Miller, J. McCullough, M. Ziman, and D. I. Johnson. 1995. Genetic and biochemical analysis of Cdc42p function in S. cerevisiae and S. pombe., Meth. Enzymol. 256:281-290.
  12. Ottilie, S., P. J. Miller, D. I. Johnson, C. L. Creasy, M. A. Sells, S. Bagrodia, S. L. Forsburg, and J. Chernoff. 1995. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J. 14:5908-5919.
  13. Akada, R., L. Kallal, D. I. Johnson, and J. Kurjan. 1996. Genetic relationships between the G protein beta-gamma complex, Ste5p, Ste20p and Cdc42p: Investigation of effector roles in the yeast pheromone response pathway. Genetics 143:103-117.
  14. Miller, P. J., and D. I. Johnson. 1997. Characterization of the S. cerevisiae cdc42-1ts allele and new temperature-conditional-lethal cdc42 alleles. Yeast 13:561-572.
  15. Collins, C. C. and D. I. Johnson. 1997. An Arabidopsis thaliana EST cDNA that encodes a Rac-like protein. Plant Physiol. 113: 1463.
  16. White, W. H. and D. I. Johnson. 1997. Characterization of synthetic-lethal mutants reveals a role for the S. cerevisiae guanine-nucleotide exchange factor Cdc24p in vacuole function and Na+ tolerance. Genetics 147:43-55.
  17. Davis, C. R., T. J. Richman, S. B. Deliduka, J. O. Blaisdell, C. C. Collins, and D. I. Johnson. 1998. Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant-lethal cdc42G12V and dominant-negative cdc42D118A mutations. J. Biol. Chem. 273:849-858.
  18. Zhang, B., Y. Zhang, C. C. Collins, D. I. Johnson, and Y. Zheng. 1999. A built-in arginine finger triggers the self-stimulatory GTPase-activating activity of Rho family GTPases. J. Biol. Chem. 274:2609-2612.
  19. Johnson, D.I. 1999. Cdc42: An Essential Rho-type GTPase Controlling Eukaryotic Cell Polarity. Microbiol. Mol. Biol. Rev. 63:54-105.
  20. Potikha, T. S., C. C. Collins, D. I. Johnson, D. P. Delmer, and A. Levine. 1999. The involvement of hydrogen peroxide in the differentiation of secondary walls in cotton fibers. Plant Physiol.119:849-858.
  21. Richman, T. J., M. M. Sawyer, and D. I. Johnson. 1999. The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. J. Biol. Chem. 274:16861-16870.
  22. Toenjes, K. A., M. M. Sawyer, and D. I. Johnson. 1999. The guanine-nucleotide exchange factor Cdc24p is targeted to the nucleus and polarized growth sites. Curr. Biol. 9:1183-1186.
  23. Murray, J. M., and D. I. Johnson. 2000. Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe. Genetics154:155-165.
  24. Merla, A., and D. I. Johnson. 2000. The Cdc42p GTPase is targeted to the site of cell division in the fission yeast Schizosaccharomyces pombe. Eur. J. Cell Biol. 79:469-477
  25. Richman, T. J., and D. I. Johnson. 2000.Saccharomyces cerevisiae Cdc42p GTPase is involved in preventing the recurrence of bud emergence during the cell cycle Mol. Cell. Biol. 20:8548-8559.
  26. Murray, J. M., and D. I. Johnson. 2001. The Cdc42p GTPase and its regulators Nrf1p and Scd1p are involved in endocytic trafficking in the fission yeast S. pombe. J. Biol. Chem.276:3004-3009.
  27. Merla, A., and D. I. Johnson. 2001.The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway. Curr. Genet.39:205-209
  28. Müller, O., D. I. Johnson, A. Mayer. 2001. Cdc42p functions at the docking stage of intracellular membrane fusion. EMBO J. 20:5657-5665.
  29. Richman, T. J., M. M. Sawyer, D. I. Johnson. 2002. Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryotic Cell1:458-468.
  30. Toenjes, K. A., D. Simpson, D. I. Johnson. 2004. Separate membrane targeting and anchoring domains function in the localization of the S. cerevisiae Cdc24p guanine nucleotide exchange factor. Curr. Genet.45:257-264.
  31. Richman, T. J., K. A. Toenjes, S. E. Morales, K. C. Cole, B. T. Wasserman, C. M. Taylor, J. A. Koster, M. Whelihan, and D. I. Johnson. 2004. Analysis of cell-cycle specific localization of the Rdi1p RhoGDI and the structural determinants required for Cdc42p membrane localization and clustering at sites of polarized growth. Curr. Genet. 45:339-349.
  32. vandenBerg, A., K. A. Toenjes, A. Ibrahim, J. E. Edwards, Jr., and D. I. Johnson. 2004. Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicans. Eukaryotic Cell 3:724-734 .
  33. Toenjes K. A., S. M. Munsee, A. S. Ibrahim, R. Jeffrey, J. E. Edwards Jr, and D. I. Johnson. 2005. Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans. Antimicrob. Agents Chemother. 49:963-972.
  34. Cole, K.C., H. W. McLaughlin, D. I. Johnson.  2007.  Use of bimolecular fluorescence complementation to study in vivo interactions between Saccharomyces cerevisiae Cdc42p and Rdi1p.  Eukaryotic Cell 6:378-387.
  35. Toenjes, K.A., B.C. Stark, K.M. Brooks, D.I. Johnson. 2009. Inhibitors of cellular signaling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicansJ. Med. Microbiol. 58:779-790.

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