University of Vermont

The University of Vermont Cancer Center

Bio for Ralph Budd, M.D.
Ralph Budd, M.D.

Ralph Budd, M.D.

Professor of Medicine and Microbiology & Molecular Genetics
Director, Vermont Center for Immunology & Infectious Diseases
Unit Director, Immunobiology Medicine, Department of Medicine


Contact Information
E-mail: ralph.budd@uvm.edu
Office Location:
D-305B Given Bldg., 89 Beaumont Ave., Burlington, VT 05405-0068

Website

www.uvm.edu/medicine/vciid
www.uvm.edu/medicine/medicine/immunobiology

Education

1969-1970 M.I.T., Cambridge, MA
1970-1973 B.A. (Biology), Cornell University, Ithaca, NY
1973-1977 M.D., Cornell University Medical College, New York, NY

Research Interests

Regulation of caspases in the immune system;
Function of gamma/delta T cells.

Academic Appointments

1988-1989 Scientist, Division of Molecular Immunology, Genentech, Inc. Clinical Assistant Professor of Medicine, Stanford University School of Medicine, Stanford CA.
1989-1992 Assistant Professor of Medicine, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT.
1992-1997 Associate Professor of Medicine, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT
1995-present Director, Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT
1995-present Associate Chair of Research Training, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT
1997-present Professor of Medicine, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT
2006-present Director, Vermont Center for Immunology and Infectious Diseases (VCIID), The University of Vermont

Awards and Honors

1974-1977 Joseph Collins Foundation Scholar, Cornell Medical College.
1983-1986 Arthritis Foundation Postdoctoral Fellow Member.
1989-1992 RJR Nabisco Research Scholars Award in Immunology.
1990-1994 Pew Scholars Program Award in the Biomedical Sciences.
1994-present Member, American Society for Clinical Investigation
1998-1999 Fogarty International Fellow, Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland
2009-2010 University Scholar, University of Vermont
2011-present  Member, Association of American Physicians
2013 University of Vermont Medical Group – Senior Researcher of the Year

Publications

To view more and/or the most recent of Dr. Budd's publications, please visit Pub Med

Logan A, Shabalina IG, Prime TA, Rogatti S, Kalinovich AV, Hartley RC, Budd RC, Cannon B, Murphy MP. In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell. 2014 Mar 13. doi: 10.1111/acel.12212. PubMed PMID: 24621297

Koenig A, Sateriale A, Budd RC, Huber SA, Buskiewicz IA. The role of sex differences in autophagy in the heart during coxsackievirus B3-induced myocarditis. J Cardiovasc Transl Res. 2014 Mar;7(2):182-91. doi: 10.1007/s12265-013-9525-5. PubMed PMID: 24323874

Saligrama PT, Fortner KA, Secinaro MA, Collins CC, Russell JQ, Budd RC. IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3. Cell Death Differ. 2014 Feb 7. doi: 10.1038/cdd.2014.10. PubMed PMID: 24510126

Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC. The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor kappaB (NF-kappaB), and caspase-8 and T cell survival. J Biol Chem. 2014 Jan 10;289(2):1183-91. doi: 10.1074/jbc.M113.506428. Epub 2013 Nov 25. PubMed PMID: 24275659

Ather JL, Fortner KA, Budd RC, Anathy V, Poynter ME. Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells. Cell Death Dis. 2013 Sep 5;4:e786. doi: 10.1038/cddis.2013.327. PubMed PMID: 24008730

Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME. Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. Am J Respir Cell Mol Biol. 2013 May;48(5):655-64. doi: 10.1165/rcmb.2012-0423OC. PubMed PMID: 23371061

Roberts BJ, Moussawi M, Huber SA. Sex differences in TLR2 and TLR4 expression and their effect on coxsackievirus-induced autoimmune myocarditis. Exp Mol Pathol. 2013 Feb;94(1):58-64. doi: 10.1016/j.yexmp.2012.06.005.  PubMed PMID: 22750431

Buskiewicz IA, Koenig A, Huber SA, Budd RC. Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses. Future Virol. 2012 Dec;7(12):1221-1236. PubMed PMID: 23503762