University of Vermont

The University of Vermont Cancer Center

Bio for Marc S. Greenblatt, M.D.
Marc S. Greenblatt, M.D.

Marc S. Greenblatt, M.D.

Professor of Medicine, Hematology/Oncology Division, Department of Medicine

Contact Information
Office Location:
Hematology/Oncology Division, Given Building, Suite E214, 89 Beaumont Avenue, Burlington, VT 05405


1978-1980   Penn State University, University Park, PA --June 1978-August 1979, June 1980-August 1980
1981            B.S. in Science with highest distinction, Penn State University
1979-1983   Jefferson Medical College, Philadelphia, PA
1983   M.D.  Jefferson Medical College

Postdoctoral Training

1983-1986 Intern and Resident, Internal Medicine University of New Mexico Affiliated Hospitals Albuquerque, NM
1987          Chief Resident, Internal MedicineUniversity of New Mexico Affiliated Hospitals Albuquerque, NM
1988-1991 Fellow, Division of Hematology/Oncology University of New Mexico Affiliated Hospitals Albuquerque, NM
1992-1995 Postdoctoral Biotechnology Fellow Laboratory of Human Carcinogenesis Curtis C. Harris, M.D., Chief National Cancer Institute, NIH, Bethesda, MD

Certification/Board Eligibility

1984   National Board of Medical Examiners
1986   American Board of Internal Medicine
1991, 2001, 2011   American Board of Internal Medicine Subspecialty in Medical Oncology

Clinical Expertise

Gastrointestinal Cancers

Cancer Genetics (Familial Cancer Program)


Dr. Greenblatt's research interests are in interpreting genetic variants in cancer susceptibility genes by using multiple lines of evidence (epidemiology, statistics, tumor pathology, evolution, structure, and function, computational algorithms). He has led projects that have integrated in vitro and in silico (computational) data to interpret genetic variation. Dr. Greenblatt’s current research activities involve interpretation of variants in the DNA mismatch Repair genes that are responsible for Lynch syndrome, the most common form of hereditary colorectal cancer.

Professional Societies

Alliance for Clinical Trials in Oncology

American Association of Cancer Research
American Society of Human Genetics
American Society of Clinical Oncology
Collaborative Group of the Americas on Inherited Colorectal Cancer
Human Genome Variation Society, Council Member
Human Genome Organization (HUGO) Mutation Database Initiative
Human Variome Project, Scientific Advisory Council 
IARC Working Group on Unclassified Genetic Variants
International Society for Gastrointestinal Hereditary Tumors (InSiGHT)
National Surgical Adjuvant Breast Program
Vermont Medical Society


Selected publications:
Plon, SE, Eccles, DM, Easton, D, Foulkes, WD, Genuardi, M, Greenblatt, MS, Hogervorst, FBL, Hoogerbrugge, N, Spurdle, AB,  Tavtigian, S, for the IARC Unclassified Genetic Variants Working Group (2008). Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results, Human Mutation, 29:1282-1291, 2008.

Tavtigian SV, Greenblatt MS, Lesueur F, Byrnes GB, for the IARC Unclassified Genetic Variants Working Group, In silico analysis of missense substitutions using sequence-alignment based methods, Human Mutation, 29:1327-1336, 2008.

Goldgar DE, Easton DF, Byrnes GB, Spurdle AB, Iversen ES, Greenblatt MS, for the IARC Unclassified Genetic Variants Working Group7, Genetic evidence and integration of various data sources for classifying uncertain variants into a single model, Human Mutation, 29:1265-1272, 2008.

Cotton RGH, Auerbach AD, Axton M, Barash C, Berkovic S, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey SM, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido M-J, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J,and Watson M,  The Human Variome Project, Science, 322(5903):861-862, 2008.

Miller PJ, Duraisamy S, Newell JA, Chan PA, Tie MM, Rogers AE, Ankuda CK, von Walstrom GM, Bond JP, Greenblatt MS, Classifying Variants of CDKN2A Using Computational and Laboratory Studies, Hum Mutat 2011 32:900-911.  PMID: 21462282

For a complete list of Marc Greenblatt's publications, please visit Google Scholar.