University of Vermont

The University of Vermont Cancer Center

Bio for Albert van der Vliet, Ph.D.
Albert van der Vliet, Ph.D.

Albert van der Vliet, Ph.D.

Professor, Department of Pathology & Laboratory Medicine


Contact Information
E-mail: Albert.van-der-Vliet@uvm.edu
Office Location:
Given Bldg D205

Expertise

The main goal of the van der Vliet laboratory is to unravel the molecular mechanisms by which biological and environmental oxidants contribute to lung cell injury, inflammation, and remodeling, as major features of chronic lung diseases such as asthma, COPD and lung cancer.

Research Interests

Nitric oxide synthases and NADPH oxidases in airway biology and pathology; Oxidant mechanisms in inflammation; Chemistry and biology of reactive oxygen and nitrogen species; Environmental oxidants and electrophiles; Lung epithelial cell biology and signaling; Chemical mechanisms of protein oxidation; Proteomic analysis of oxidation and alkylation targets; Antioxidant enzymes and micronutrients.

Postdoctoral Training

2/93 - 4/97 Postdoctoral Researcher, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis
6/91 - 1/93 Postdoctoral Researcher, Division of Molecular Pharmacology,Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands

Education

1991 Ph.D. Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
1987  B.S./M.S. Subfaculty of Chemistry, Faculty of Mathematics and Physical Sciences, Vrije Universiteit, Amsterdam, The Netherlands

Academic Appointments

2008 - Present Professor, Department of Pathology, College of Medicine, University of Vermont, Burlington, VT
2002 -2008 Associate Professor, Department of Pathology, College of Medicine, University of Vermont, Burlington, VT
2001 - 2002 Associate Professor in Residence, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis
1999 - 2001 Assistant Professor in Residence, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis.
1997 - 1999 Assistant Research Biochemist, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis
1995 Visiting Scientist, Pharmacology Group, King's College, Chelsea Campus, University of London, U.K.

Awards and Honors

1999  Joan Oettinger Memorial Award, UC Davis School of Medicine
1996-1998  Parker B. Francis Fellowship Award in Pulmonary Research, Francis Family Foundation
1994-1996   Postdoctoral Fellowship, American Heart Association, California Affiliate
1994  Young Investigator Award, The Oxygen Society

Publications

O’Brien E, Spiess PC, Habibovic A, Hristova M, Bauer RA, Randall MJ, Poynter ME, and van der Vliet A (2015) Inhalation of the Reactive Aldehyde Acrolein Promotes Antigen Sensitization to Ovalbumin and Enhances Neutrophilic Inflammation. J. Immunotoxicol Apr 15:1-7. [Epub ahead of print]. PMID: 25875327

Kaiser S, MacPherson MB, James TA, Emery A, Spiess P, van der Vliet A, Landry CC, Shukla A (2014) Exploratory use of docetaxel loaded acid-prepared mesoporous spheres for the treatment of malignant melanoma. Cancer Nanotechnol. 6:1. Epub 2015 Jan 24. PMCID: PMC4305083

Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM (2014) The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor kB proteins. Free Radic. Biol. Med. 73:143-53. PMCID: PMC4111997

Hristova M, Veith C, Habibovic A, Lam YW, Deng B, Geiszt M, Janssen-Heininger YM, van der Vliet A. (2014) Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells. Redox Biol. 2:436-46. PMCID: PMC3949091

Randall MJ, Hristova M, van der Vliet A. (2013) Protein alkylation by the a,ß-unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling? FEBS Lett. 587(23):3808-14 PMCID: PMC3879783

For a complete list of Albert van der Vliet's publications, please visit PubMed.