University of Vermont

College of Medicine

Vermont Cancer Center

Bio for Yvonne Janssen-Heininger, Ph.D.
Yvonne Janssen-Heininger, Ph.D.

Yvonne Janssen-Heininger, Ph.D.

Professor
Department of Pathology


Contact Information
E-mail: Yvonne.Janssen@uvm.edu
Office Location:
Health Science Research Facility 216A

Website

Janssen-Heininger Lab

Education

1988  BA/MS - University of Limburg, Maastricht, The Netherlands
Major: Biological Health Sciences, Faculty of Health Sciences
1993  Ph.D.: Maastricht University, The Netherlands
In alliance with: Maastricht University Medical Center, Di-One Institute

Academic Interests

To provide an exciting research environment and extensive mentoring to all laboratory members to enable each of them to be maximally successful in the arena of biomedical sciences in diverse capacities.

Expertise

Epithelial control of lung inflammation
Epithelial signaling in fibrosis
Redox biology in environmental lung disease
Technologies and functioning in the laboratory

Research Interests

To unravel the molecular basis of diverse pulmonary diseases by emphasizing the biology of epithelial cells and redox-dependent processes.

Academic Appointments

2008 - Present Professor, University of Vermont, Department of Pathology, Burlington, VT
1999 - Present Adjunct Professor, Department of Pulmonology University of Maastricht, Maastricht, The Netherlands
2002 - 2008 Associate Professor, University of Vermont, Department of Pathology, Burlington, VT
1997 - 2002  Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1996 - 1997 Research Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1993 - 1996  Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT

Awards and Honors

1994  "Thesis Award 1992-1993" Nutrition Toxicology and Environmental Research Institute, Maastricht, The Netherlands
1995-1998  "Parker B. Francis Fellowship in Pulmonary Research"
1996  "JAAP Swierenga Award", Dutch College of Chest Physicians, The Netherlands
1996-1997  "Senator Proctor Research Award", American Lung Association of Vermont
2002-2005  Member, National Institutes of Health, Lung Biology and Pathology Study Section
2010-2016  Member, National Institutes of Health, Lung Injury, Repair and Remodeling Study Section
2010  "J. Walter Juckett Scholar Award", Lake Champlain Cancer Research Organization

Publications

2012 van der Velden J, Janssen-Heininger YMW, Mandalapu S, Scheller EV, Kolls JK, and Alcorn JF: Differential requirement for c-jun N-terminal kinase 1 in lung inflammation and host defense. PLoS ONE 7(4):e34638, 2012 PMCID: PMC3326034

2012 Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC, and Janssen-Heininger YMW: Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death (invited review). Antioxid Redox Signal. 16(6):496-505, 2012 PMCID: PMC3304251.

2011 Aesif SW, Kuipers I, van der Velden J, Tully JE, Guala AS, Anathy V, Sheely JI, Reynaert NL, Wouters EF, van der Vliet A, Janssen-Heininger YM. Activation of the glutaredoxin-1 gene by nuclear factor ?B enhances signaling. Free Radic Biol Med. 2011 Jun 27.

2011 Olson N, Kasahara DI, Hristova M, Bernstein R, Janssen-Heininger Y, van der Vliet A. Modulation of NF-?B and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol. 2011 Jun;44(6):813-23.

2011 Ather JL, Hodgkins SR, Janssen-Heininger YM, Poynter ME. Airway epithelial NF-?B activation promotes allergic sensitization to an innocuous inhaled antigen. Am J Respir Cell Mol Biol. 2011 May;44(5):631-8.

2011 Kuipers I, Guala AS, Aesif SW, Konings G, Bouwman FG, Mariman EC, Wouters EF, Janssen-Heininger YM, Reynaert NL. Cigarette Smoke Targets Glutaredoxin 1, Increasing S-glutathionylation and Epithelial Cell Death. Am J Respir Cell Mol Biol. 2011 Apr 7.

For a complete list of Yvonne Janssen-Heininger's publications, please visit PubMed.