Bio for Nicholas Heintz, Ph.D. Nicholas Heintz, Ph.D.Professor Emeritus, Department of Pathology & Laboratory Medicine Contact Information E-mail: Nicholas.Heintz@uvm.eduOffice Location: Health Science Research Facility 328 Academic InterestsTo improve interdisciplinary opportunities for graduate education in the biomedical sciences.Research InterestsTo exploit perturbations in redox signaling to develop new therapeutic approaches to treat malignant mesothelioma and other solid tumor types.Postdoctoral Training1979-1983 University of Virginia Postdoc Molecular GeneticsEducation1979 University of Vermont Ph.D. Medical Microbiology1976 University of Vermont M.S Cell Biology1971 College of Holy Cross B.A. English LiteratureAcademic Appointments2014-Present Professor Emeritus, Department of Pathology and Laboratory Medicine2010-2012 Interim Director, Basic Science Research, Vermont Cancer Center2002-2006 Leader, Cell Signaling and Growth Control Program, Vermont Cancer Center2002-2006 Director, DNA Analysis and Flow Cytometry Cores, Vermont Cancer Center1999-2014 Professor of Pathology, University of Vermont School of Medicine1999-2014 Professor of Microbiology and Molecular Genetics, University of Vermont College of Medicine1992-1999 Associate Professor, Department of Pathology, University of Vermont College of Medicine1992-1999 Associate Professor of Microbiology and Molecular Genetics, University of Vermont College of Medicine1986-1992 Assistant Professor of Pathology, University of Vermont College of Medicine1983-1986 Research Assistant Professor of Pathology, University of Vermont College of MedicineAwards and Honors2002 Visiting Research Professor, European Institute of Oncology, Milan Italy2001-2002 Senior Research Service Award, NIHGMS1994-1998 American Cancer Society Personnel A Committee1993-1998 American Cancer Society Faculty Research Award1997 Foundation for the Promotion of Cancer Research, Senior Visiting Professor, National Cancer Center Research Institute, Tokyo, Japan.1994-1996 Molecular Biology Study Section, NIH1993-1994 J. Walter Juckett Scholar, Lake Champlain Cancer Research Organization1986 Visiting Scientist Fellowship, MBCRR, Harvard University1979-1983 National Research Service Award, National Institutes of Health1982 President’s and Board Visitors’ Research Prize, University of Virginia1979 Postdoctoral Research Fellowship, American Cancer Society (declined)1978 President’s Fellowship, American Society for MicrobiologyPublications2011 N. Olson, M. Hristova, N. Heintz, K. M. Lounsbury, and A. van der Vliet. Activation of hypoxia inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Am. J. Physiol. Lung Cell. Mol. Physiol. 301:L993-L1002, 2011. PMCID: PMC32338302011 Shukla A, Hillegass JM, Macpherson MB, Beuschel SL, Vacek PM, Butnor KJ, Pass HI, Carbone M, Testa JR, Heintz NH, Mossman BT. ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. Int J Cancer. 2011 Sep 1;129(5):1075-86. doi: 10.1002/ijc.25763.2010 Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublié S. tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20305-10.2010 I. D. Odell, K. Newick, N. H. Heintz, S. S. Wallace, and D. S. Pederson. Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1. DNA Repair 9:134-143, 2010.2009 A. Shukla, M. W. Bosenberg, M. B. Macpherson, K. J. Butnor, N. H. Heintz, H. I. Pass, M. Carbone, J. R. Testa, and B. T. Mossman. Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. Am. J. Pathol. 175:2197-2206, 2009.To view a complete list of Nicholas Heintz's publications, please visit PubMed.