University of Vermont

The University of Vermont Cancer Center

Bio for Nicholas Heintz, Ph.D.
Nicholas Heintz, Ph.D.

Nicholas Heintz, Ph.D.

Professor of Pathology
Department of Pathology and Vermont Cancer Center


Contact Information
E-mail: Nicholas.Heintz@uvm.edu
Office Location:
Health Science Research Facility 328

Website

Heintz Lab

Education

1979-1983 University of Virginia Postdoc Molecular Genetics
1979 University of Vermont Ph.D. Medical Microbiology
1976 University of Vermont M.S Cell Biology
1971 College of Holy Cross B.A. English Literature

Academic Interests

To improve interdisciplinary opportunities for graduate education in the biomedical sciences.

Research Interests

To exploit perturbations in redox signaling to develop new therapeutic approaches to treat malignant mesothelioma and other solid tumor types.

Academic Appointments

2010-present Interim Director, Basic Science Research, Vermont Cancer Center
2002-2006 Leader, Cell Signaling and Growth Control Program, Vermont Cancer Center
2002-2006 Director, DNA Analysis and Flow Cytometry Cores, Vermont Cancer Center
1999-present Professor of Pathology, University of Vermont School of Medicine
1999-present Professor of Microbiology and Molecular Genetics, University of Vermont College of Medicine
1992-1999 Associate Professor, Department of Pathology, University of Vermont College of Medicine
1992-1999 Associate Professor of Microbiology and Molecular Genetics, University of Vermont College of Medicine
1986-1992 Assistant Professor of Pathology, University of Vermont College of Medicine
1983-1986 Research Assistant Professor of Pathology, University of Vermont College of Medicine

Awards and Honors

2002 Visiting Research Professor, European Institute of Oncology, Milan Italy
2001-2002 Senior Research Service Award, NIHGMS
1994-1998 American Cancer Society Personnel A Committee
1993-1998 American Cancer Society Faculty Research Award
1997 Foundation for the Promotion of Cancer Research, Senior Visiting Professor, National Cancer Center Research Institute, Tokyo, Japan.
1994-1996 Molecular Biology Study Section, NIH
1993-1994 J. Walter Juckett Scholar, Lake Champlain Cancer Research Organization
1986 Visiting Scientist Fellowship, MBCRR, Harvard University
1979-1983 National Research Service Award, National Institutes of Health
1982 President’s and Board Visitors’ Research Prize, University of Virginia
1979 Postdoctoral Research Fellowship, American Cancer Society (declined)
1978 President’s Fellowship, American Society for Microbiology

Publications

2011 N. Olson, M. Hristova, N. Heintz, K. M. Lounsbury, and A. van der Vliet.  Activation of hypoxia inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Am. J. Physiol. Lung Cell. Mol. Physiol. 301:L993-L1002, 2011.  PMCID: PMC3233830

2011 Shukla A, Hillegass JM, Macpherson MB, Beuschel SL, Vacek PM, Butnor KJ, Pass HI, Carbone M, Testa JR, Heintz NH, Mossman BT. ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. Int J Cancer. 2011 Sep 1;129(5):1075-86. doi: 10.1002/ijc.25763.

2010 Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublié S. tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20305-10.

2010 I. D. Odell, K. Newick, N. H. Heintz, S. S. Wallace, and D. S. Pederson. Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1. DNA Repair 9:134-143, 2010.

2009 A. Shukla, M. W. Bosenberg, M. B. Macpherson, K. J. Butnor, N. H. Heintz, H. I. Pass, M. Carbone, J. R. Testa, and B. T. Mossman. Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. Am. J. Pathol. 175:2197-2206, 2009.

To view a complete list of Nicholas Heintz's publications, please visit PubMed.