University of Vermont

College of Medicine

Vermont Cancer Center

Bio for Karen M. Lounsbury, Ph.D.
Karen M. Lounsbury, Ph.D.

Karen M. Lounsbury, Ph.D.

Professor
Department of Pharmacology


Contact Information
E-mail: Karen.Lounsbury@uvm.edu
Phone:
(802)656-1319
Office Location:
Health Sci Rsrch Facility, Rm 320

Website

Lab

Education

1980-1983 Easton Area High School, Easton, PA

1983-1987 B.S. Biochemistry; The Pennsylvania State University, University Park, PAResearch Mentor: Dr. Richard Bernlohr, Ph.D.

1987-1993 Ph.D. Pharmacology; Department of PharmacologyThe University of Pennsylvania, Philadelphia, PADissertation Advisor: Dr. David Manning, Ph.D.

1993-1996 Post-doctoral Fellow; Department of Pathology and Vermont Cancer Center, The niversity of Vermont, Burlington, VT. Supervisor: Dr. Ian Macara, Ph.D.

1996-1997 Post-doctoral Associate; Department of PharmacologyThe University of Vermont, Burlington, VTSupervisor: Dr. Mark Nelson, Ph.D. and Dr. Joseph Brayden, Ph.D.

Research Interests

Signal Transduction in Vascular Remodeling: Signaling through transcription factors during normal or pathological cell growth; tumor angiogenesis; hypertension and atherosclerosis; regulation by calcium, growth factors and hypoxia/ischemia; control of timed cell division; nuclear transport kinetics; subcellular imaging of signaling molecules; manipulation of recombinant protein structure/function.

Academic Appointments

1999 - Present Cell and Molecular Biology Faculty; University of Vermont, Burlington, VT

1998 - Present Member Vermont Cancer Center; University of Vermont, Burlington, VT

1998 - 2004 Assistant Professor of Pharmacology, University of Vermont, Burlington, VT

2010 - Present Professor of Pharmacology, University of Vermont, Burlington, VT

2004 - 2010 Associate Professor of Pharmacology, University of Vermont, Burlington, VT

Publications

2011 Cassavaugh J, Lounsbury KM. Hypoxia-mediated biological control. J Cell Biochem. 112(3):735-44. doi: 10.1002/jcb.22956, 2011.

2010 Cassavaugh J, Lounsbury KM. Hypoxia-mediated biological control. J Cell Biochem. 2010.

2009 Buder-Hoffmann, SA, Shukla, A, Barrett, TF, Macpherson, MB, Lounsbury, KM, Mossman BT. A Protein Kinase C{delta}-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos. Am. J. Pathol. 174:449-59, 2009.

strong>2008 Bove, PF, Hristova, M, Wesley, UV, Olson, N, Lounsbury, KM, and van der Vliet, A, Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1?.  J.Biol.Chem, 283:17919-28, 2008.

2008 Barlow, CA, Kitiphongspattana, K, Siddiqui, N, Roe, MW, Mossman, BT, and Lounsbury, KM.  Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells. Apoptosis, 13:681-92, 2008.

For a complete list of Karen M. Lounsbury's publications, please visit PubMed.