University of Vermont

College of Medicine

Vermont Cancer Center

Bio for Karen M. Lounsbury, Ph.D.
Karen M. Lounsbury, Ph.D.

Karen M. Lounsbury, Ph.D.

Professor
Department of Pharmacology


Contact Information
E-mail: Karen.Lounsbury@uvm.edu
Phone:
(802)656-1319
Office Location:
Health Sci Rsrch Facility, Rm 320

Website

Lab

Education

1980-1983 Easton Area High School, Easton, PA

1983-1987 B.S. Biochemistry; The Pennsylvania State University, University Park, PAResearch Mentor: Dr. Richard Bernlohr, Ph.D.

1987-1993 Ph.D. Pharmacology; Department of PharmacologyThe University of Pennsylvania, Philadelphia, PADissertation Advisor: Dr. David Manning, Ph.D.

1993-1996 Post-doctoral Fellow; Department of Pathology and Vermont Cancer Center, The niversity of Vermont, Burlington, VT. Supervisor: Dr. Ian Macara, Ph.D.

1996-1997 Post-doctoral Associate; Department of PharmacologyThe University of Vermont, Burlington, VTSupervisor: Dr. Mark Nelson, Ph.D. and Dr. Joseph Brayden, Ph.D.

Research Interests

Signal Transduction in Vascular Remodeling: Signaling through transcription factors during normal or pathological cell growth; tumor angiogenesis; hypertension and atherosclerosis; regulation by calcium, growth factors and hypoxia/ischemia; control of timed cell division; nuclear transport kinetics; subcellular imaging of signaling molecules; manipulation of recombinant protein structure/function.

Academic Appointments

1999 - Present Cell and Molecular Biology Faculty; University of Vermont, Burlington, VT

1998 - Present Member Vermont Cancer Center; University of Vermont, Burlington, VT

1998 - 2004 Assistant Professor of Pharmacology, University of Vermont, Burlington, VT

2010 - Present Professor of Pharmacology, University of Vermont, Burlington, VT

2004 - 2010 Associate Professor of Pharmacology, University of Vermont, Burlington, VT

Publications

For a complete list of Karen M. Lounsbury's publications, please visit PubMed.

2014  Shao Y, Wellman TL, Lounsbury KM, Zhao FQ.  Differential regulation of GLUT1 and GLUT8 expression by hypoxia in mammary epithelial cells.  Am J Physiol Regul Integr Comp Physiol.  2014 Aug 1:  307(3):  R237-247.  doi:  10.1152/ajpregu.00093.2014.  PMID:  24920730

2013  Williams TF, Mirando AC, Wilkinson B, Francklyn CS, Lounsbury KM.  Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.  Sci Rep.  2013;  3:1317.  doi:  10.1038/srep01317.  PMID:  23425968, PMCID:  PMC3578223

2011  Cassavaugh JM, Hale SA, Wellman TL, Howe AK, Wong C, Lounsbury KM.  Negative Regulation of HIF-1alpha by an FBW7-mediated degradation pathway during hypoxia.  J Cell Biochem.  2011 Dec;  112(12):  3882-3890.  doi:  10.1002/jcb.23321.  PMID:  21964756,  PMCID:  PMC3202039

2011  Olson N, Hristova M, Heintz NH, Lounsbury KM, van der Vliet A.  Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.  Am J Physiol Lung Cell Mol Physiol.  2011 Dec;  301(6):  L993-L1002.  doi:  10.1152/ajplung.00250.2011.  PMID:  21926263,  PMCID:  PMC3233830

2011  Cassavaugh J, Lounsbury KM.  Hypoxia-mediated biological control. J Cell Biochem. 2011 Mar; 112(3): 735-744.  doi: 10.1002/jcb.22956.  PMID:  21328446

2009  Buder-Hoffmann SA, Shukla A, Barrett TF, Macpherson MB, Lounsbury KM, Mossman BT.  A Protein Kinase Cdelta-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos. Am. J. Pathol. 2009 Feb; 174(2): 449-459.  doi:  10.2353ajath.2009.080180.  PMID:  19116364,  PMCID:  PMC2630554

2008  Bove PF, Hristova M, Wesley UV, Olson N, Lounsbury KM, van der Vliet A.  Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1alpha.  J Biol Chem.  2008 Jun 27;  283(26):  17919-17928.  doi:  10.1074/jbc.M709914200.  PMID:  18424783, PMCID:  PMC2440600

2008 Barlow, CA, Kitiphongspattana, K, Siddiqui, N, Roe, MW, Mossman, BT, and Lounsbury, KM.  Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells. Apoptosis, 13:681-92, 2008.

2008  Lounsbury KM.  Preventing stenosis by local inhibition of KCa3.1:  a finger on the phenotypic switch.  Arterioscler Thromb Vasc Biol.  2008 Jun;  28(6):  1036-8.  doi:  10.1161/ATVBAHA.108.164988.  PMID:  18495973