University of Vermont

College of Medicine

Vermont Cancer Center

Bio for Alan K. Howe, Ph.D.
Alan K. Howe, Ph.D.

Alan K. Howe, Ph.D.

Associate Professor
Department of Pharmacology


Contact Information
E-mail: Alan.Howe@uvm.edu
Phone:
(802)656-9521
Office Location:
Health Sci Rsrch Facility, Rm 322

Website

Lab

Education

1996 Ph.D. Northwestern University, Evanston IL, Tumor Cell Biology

1990 B.S. University of New Hampshire, Durham NH, Biochemistry

Awards and Honors

2010-2011 Nominee, Silver Stethoscope Award for Teaching Excellence, UVM College of Medicine

2010 Invited Speaker, Gordon Research Conference on Signaling by Adhesion Receptors

2010 Distinguished Alumnus Speaker, Lineberger Comprehensive Cancer Center Postdoctoral Fellow  
          Training Grant, University of North Carolina at Chapel Hill

2001 Recipient, Howard Temin Career Award (NCI)

1999-2001 Postdoctoral fellow, American Cancer Society

1999 UNC-CH Nominee, Burroughs Wellcome Fund Career Award in the Biomedical Sciences

1996 Fellow, Lineberger Comprehensive Cancer Center Postdoctoral Training Award

1994-1995 Graduate fellow, Ingberman Charitable Trust

1991-1992 Graduate Fellow, Chicago Baseball Cancer Charities, Northwestern University

1990 Graduate Fellow, Carcinogenesis Training Grant, Northwestern University

1990 Graduated cum laude, University of New Hampshire

Patents

Phosphoprotein detection reagent and methods of making and using the same; U.S. Patent No. 7,799,526 (Licensed by InvitrogenTM)

Publications

For a complete list of Alan K. Howe's publications, please visit PubMed.

2013  Langevin HM, Nedergaard M, Howe AK.  Cellular control of connective tissue matrix tension.  J Cell Biochem.  2013 Aug;  114(8):  1714-1719.  doi:  10.1002/jcb.24521.  PMID:  23444198,  PMCID:  PMC3746739

2013  Abbott RD, Koptiuch C, Latridis JC, Howe AK, Badger GJ, Langevin HM.  Stress and matrix-responsive cytoskeletal remodeling in fibroblasts.  J Cell Physiol.  2013 Jn;  228(1):  50-57.  doi:  10.1002/jcp.24102.  PMID:  22552950,  PMCID:  PMC2414643

2012  Abbott RD, Howe AK, Langevin HM, Latris JC.  Live free or die:  stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted.  Biochem Biophys Res Commun.  2012 May 4;  421(2):  361-366.  doi:  10.1016/j.bbrc.2012.04.018.  PMID:  22516752,  PMCID:  PMC3348381

2012  Caldwell GB, Howe AK, Nickl CK, Dostmann WR, Ballif BA, Deming PB.  Direct modulation of the Protein Kinase A catalytic subunit alpha by receptor tyrosine kinases. J. Biochem. 2012 Jan; 113(1):  39-48.  doi: 10.102/jcb.23325.  PMID:  21866565, PMCID:  PMC3245341

2011  McKenzie AJ, Campbell SL, Howe AK.   Protein Kinase A activity and anchoring are required for ovarian cancer cell migration and invasion.  PLoS One.  2011;  6(10): e26552.  doi:  10.1371/journal.pone.0026552.   PMID:  22028904, PMCID:  PMC3197526 

2011  Cassavaugh JM, Hale SA, Wellman TL, Howe AK, Wong C, Lounsbury KM.  Negative regulation of HIF-1a by an FBW7-mediated degradation pathway during hypoxia. J Cell Biochem.  2011 Dec;  112(12):  3882-3890.  doi:  10.1002/jcb.23321.  PMID:  21964756, PMCID:  PMC3202039 

2011  Howe AK.  Cross-talk between calcium and protein kinase A in the regulation of cell migration.  Curr Opin Cell Biol. 2011 Oct;  23(5):  554-561.  doi:  10.1016/j.ceb.2011.05.006.  PMID:  21665456,  PMCID:  PMC3175278

2011  Langevin HM, Bouffard NA, Fox JR, Palmer BM, Wu J, Iatridis JC, Barnes WD, Badger GJ, Howe AK.  Fibroblast cytoskeletal remodeling contributes to connective tissue tension.  J Cell Physiol.  2011 May;  226(5):  1166-1175.  doi:  10.1002/jcp.22442.  PMID:  20945345,  PMCID:  PMC3053527

2010  Langevin HM, Storch KN, Snapp RR, Boffard NA, Badger GJ, Howe AK, Taatjes DJ.  Tissue stretch induces nuclear remodeling in connective tissue fibroblasts.  Histochem Cell Biol. 2010 Apr;  133(4):  405-415. doi:  10.1007/s00418-010-0680-3.  PMID:  20237796, PMCID:  PMC2880391

2009  Rivard RL, Birger M, Gaston KJ, Howe AK.  AKAP-independent localization of type-II protein kinase A to dynamic actin microspikes.  Cell Motil Cytoskel. 2009 Sep;  66(9):  693-709.  doi:  10.1002/cm.20399.  PMID:  19535823, PMCID:  PMC2837345