University of Vermont

The University of Vermont Cancer Center

Bio for Wolfgang Dostmann, Ph.D.
Wolfgang Dostmann, Ph.D.

Wolfgang Dostmann, Ph.D.

Professor
Department of Pharmacology


Contact Information
E-mail: wdostman@uvm.edu
Phone:
(802)656-0223
Office Location:
Given B333

Website

Lab

Education

1976 Abitur, Gymnasium 'Kurt-Schumacher-Allee', Bremen, Germany

1976-1983 University of Bremen, Germany. Department of Chemistry:

1983 Dipl. Chem. (M.S.), Institute of Organic Chemistry, University of Bremen, Germany.

1987 Dr. rer. nat. (Ph.D.), Institute of Organic Chemistry, University of Bremen, Germany.

1996 Dr. med. habil. (Habilitation), Institute of Pharmacology & Toxicology, Technical University of Munich, Germany.

Academic Appointments

2009 - Present Professor (tenure), Department of Pharmacology, University of Vermont, College of Medicine,

2004 – 2009 Associate Professor (tenure), Department of Pharmacology, University of Vermont, College of Medicine,

1998 - 2004 Assistant Professor, Department of Pharmacology, University of Vermont, College of Medicine,

1997 - 1998 Privatdozent (Senior Lecturer), Institute of Pharmacology and Toxicology, Faculty of Medicine, Technical University of Munich, Germany

1991 - 1997 Assistant (Lecturer), Institute of Pharmacology and Toxicology, Technical University of Munich, Germany

1989 - 1991 Research Associate, University of California at San Diego, California

1987 - 1989 Post-Doctoral Fellow, University of California at San Diego, California

1983 - 1987 Graduate Student and Teaching Assistant, University of Bremen, Institute of Organic Chemistry, Bremen, Germany

Research Grants

1998 - 2018 Research Grant, R37 DK053832, Co-investigator (PI: Mark T. Nelson). National Institute of Health, NIH/NIDDK. Ca2+ sparks and urinary bladder smooth muscle excitability. $215,000

2008 - 2013 Research Grant, R01 HL68991-02. Principal Investigator. National Institute of Health, NIH/NHLBI. Title: Exploring vasomotor mechanism using new PKG inhibitors and cGMP biosensors. $250,000

2010 - 2012 Internal Research Grant (IGP), College of Medicine, UVM. Title: The crystal structure of cGMP-dependent protein kinase

2008 - 2012 Research Grant, R01 HL085646-01, Co-investigator (PI: Albert van der Vliet). National Institute of Health, NIH/NHLBI. Title: Dual Oxidase in Airway Epithelial Repair and Remodeling. $250,000

2001 - 2012 Research Grant, R01 DK56644, Co-investigator (PI: Steven Lidofsky). National Institute of Health, NIH/NIDDK. Title: Mechanisms of cell volume regulation in liver. $212,500

2006 - 2011 Research Grant BayerHealthcare, Germany. Principal Invesigator. Title: Characterization of PKG Activators and Crystallization of PKG and Co-Crystallisation with PKG Activators. $50,000

2007 - 2009 Research Grant BayerHealthcare, Germany. Principal Investigator. Title: Analyzing the redox equilibrium of soluble guanylyl cyclase in vascular smooth muscle using BAY 58-2667 and cGMP biosensors. $37,000

Awards and Honors

1998 Lead-User Award (Surface Plasmon Resonance), BioTul Inc, Munich, Germany

1997 Venia legendi, (Privatdozent), Munich/Bavaria, Germany

1987 Doctor Graduation with honors, summa cum laude, Bremen, Germany

1985 Research Award, Sandoz Inc., East Hanover, New Jersey
1983 Masters Graduation with honors, magna cum laude, Bremen, Germany

Publications (Peer Reviewed)

For a complete list of Wolfgang Dostmann's publications, please visit PubMed.

2013  Held KF, Dostmann WR.  Real-time monitoring the spatiotemporal dynamics of intracellular cGMP in vascular smooth muscle cells.  Methods Mol Biol.  2013;  1020:  131-145.  doi:  10.1007/978-1-62703-459-3_8.  PMID:  23709030
 
2013  Moon TM, Osborne BW, Dostmann WR.  The switch helix:  a putative combinatorial relay for interprotomer communication in cGMP-dependent protein-kinase.  Biochim Biophys Acta.  2013 Jul;  1834(7):  1346-1351.  doi:  10.1016/j.bbapap.2013.02.009.  PMID:  23416533, PMCID:  PMC3683381

2012  Held KF, Dostmann WR.  Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle.  Front Pharmacol.  2012 Jul 12;  3:130.  doi:  10.3389/fphar.2012.00130.  PMID:  22807915, PMCID:  3395022

2011  Miller CL, Cai Y, Oikwa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C.  Cyclic nucleotide phosphodiesterase 1A:  a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.  Basic Res Cardiol.  2011 Nov;  106(6):  1023-1039.   doi:  10.1007/s00395-011-0228-2.  PMID:  22012077, PMCID:  4114346

2011  Osborne BW, Wu J, McFaland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL Jr., Kornev AP, Taylor SS, Dostmann WR.  Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication.  Structure.  2011 Sep 7;  19(9):  1317-1327.  doi:  10.1016/j.str.2011.06.012.  PMID:  21893290,  PMCID:  PMC3168983

2010  Batchelor AM, Bartus K, Reynell C, Constantinou S, Halvey EJ, Held KF, Dostmann WR, Vernon J, Garthwaite J.  Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors. Proc Natl Acad Sci USA.  2010 Dec 21;  107(51):  22060-22065.  doi:  10.1073/pnas.013147107.  PMID:  21145206

2010  Lavogina D, Nickl CK, Enkvist E, Raidaru G, Lust M, Vaasa A, Uri A, Dostmann WR. Adenosine analogue-oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIalpha). Biochim Biophys Acta.  2010 Sep;  1804(9):  1857-1868.  doi:  10.1016/j.bbapap.2010.04.007.  PMID:  20406699, PMCID:  3071016

2010  Nickl CK, Raidas SK, Zhao H, Sausbier M, Ruth P, Tegge W, Brayden JE, Dostmann WR.  (D)-amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ia. Biochim Biophys Acta. 2010  Mar; 1804(3): 524-532.  doi:  10.1016/j.bb.apap.2009.12.004.  PMID:  20018259, PMCID:  PMC2822062

2009  Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD.  cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Mol Brain.  2009 Aug 5; 2(1):  26.  doi:  10.1186/1756-6606-2-26.  PMID:  19656393, PMCID:  PMC2731736

2009  Pinkse MW, Rijkers DT, Dostmann WR, Heck AJ.  Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry. J Biol Chem.  2009 Jun 12;  284(24):  16354-16368.  doi:  10.1074/jbc/M808521200.  PMID:  19369251, PMCID:  PMC2713552