University of Vermont

College of Medicine

Vermont Lung Center

Bio for Lennart Lundblad, Ph.D.
Lennart Lundblad, Ph.D.

Lennart Lundblad, Ph.D.

Research Assistant Professor of Medicine, Pulmonary Medicine
Department of Medicine


Contact Information
E-mail: Lennart.Lundblad@uvm.edu
Office Location:
Medicine, Health Sci Rsrch Facility, Rm 230

Education


Ph.D. Dept. of Clinical Physiology, Malmö, Lund University, Sweden
B.Sc. Zoophysiology, University of Lund, Sweden
Pre-clinical Project Manager, AstraZeneca AB 1999 – 2000
Research Scientist, Astra AB 1993 – 2000
Research Associate, Draco AB 1987 – 1993
Research Associate and lecturer, Dep. Animal physiology, Lund University 1985 – 2000
Research Associate (2001-present); Dept. of Medicine, University of Vermont.
 

Research Interests

My research is focused on understanding the physiological and pharmacological mechanisms of airways diseases such as asthma, COPD and lung infections.  Using a multidisciplinary approach including: animal models and systems, transgenic mice, physiology, imaging and clinical studies, my colleagues and I are attempting to understand the pathophysiological basis of airways diseases to better diagnose and treat patients. The primary technique used in my laboratory to assess respiratory mechanics is the forced oscillation technique (FOT). FOT is a technique that allows for extremely precise measurements of the respiratory system and with this system we can separate events happening in the central airways from those taking place in the periphery of the lung. This expertise has been critical for the accomplishments of the lab.

In particular I am interested in the mechanisms and manifestations of airways hyperresponsiveness (AHR) and allergen induced bronchoconstriction. AHR is a complication occurring with asthma and is used in the diagnosis of asthma but even non-asthmatics can become hyperresponsive e.g. following an influenza involving the respiratory tract. Combining FOT with micro computed tomography (micro-CT) has allowed us to model how AHR manifests in the respiratory system in a unique way and explain the localization of AHR. We were recently able to publish the first-ever model of allergen-induced bronchoconstriction in mice. This achievement addresses a major shortcoming of previous mouse models of asthma and opens up completely new avenues to study the acute response in asthma. In recent work collaborating with the Trudeau Institute we are studying the contribution of influenza to allergy and AHR and in collaboration with the Thayer School of Engineering at Dartmouth college we are developing techniques to diagnose lung infections via exhaled breath.

My long term ambition is to connect the laboratory findings and the techniques developed in the laboratory with clinical research and applications. I am currently involved in a clinical trial using the forced oscillation technique to study emphysema and bronchitic inflammation. Together with clinicians and scientists at Lund University in Malmö, Sweden, we are now further developing the utility of forced oscillation technique and correlation with CT imaging. This will enable us to use FOT as an easy to use and affordable tool for clinical diagnosis and treatment efficacy, while reducing radiation exposures in the patients.

Expertise

Industry Collaboration

I have extensive experience from working within the pharmaceutical industry and continue to collaborate with industry in my academic role. I operate the Vermont Lung Center Phenotyping Facility. The Phenotyping Facility use state of the art techniques to assess lung mechanics, involving FOT and using mathematical modeling to get accurate and meaningful parameters of lung function. We currently operate eight flexiVent machines, making the facility one of the largest in the world. We also operate a micro-CT scanner allowing for down to 27µm voxel resolution and we have access to several core facilities at the College of Medicine such as the Microscopy Imaging Center, the Flow Cytometry and Cell Sorting Facility and a Biostatistical Bioinformatics Facility. In addition we collaborate extensively with several research groups within the university.

Research Grants

Grants from NIH and departmental funding, as well as grants and contracts from industry.

Publications

Antigen induced mast cell expansion and bronchoconstriction in a mouse model of asthma. Shannon Li, Minara Aliyeva, Nirav Daphtary, Rebecca A. Martin, Matthew E. Poynter, Shannon F. Kostin, Jos L. van der Velden, Alexandra M. Hyman, Christopher S. Stevenson, Jonathan E. Phillips and Lennart K.A. Lundblad. Am J Physiol - Lung. 2014 306(2):196-206.
Robust detection of P. aeruginosa and S. aureus acute lung infections by secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting: from initial infection to clearance. Zhu J, Jiménez-Díaz J, Bean HD, Daphtary NA, Aliyeva MI, Lundblad LK, Hill JE. J Breath Res. 2013, Sep;7(3):037106.
Phillips JE, Peng R, Harris P, Burns L, Renteria L, Lundblad LK, Fine JS, Bauer CM, and Stevenson CS. House dust mite models: will they translate clinically as a superior model of asthma? J Allergy Clin Immunol 132: 242-244, 2013.
Endogenous Distal Airway Progenitor Cells, Lung Mechanics, and Disproportionate Lobar Growth following Long-Term Post-Pneumonectomy in Mice. Philip Eisenhauer, Benjamin Earle, Roberto Loi, Viranuj Sueblinvong, Meagan Goodwin, Gilman B. Allen, Lennart Lundblad, Melissa R. Mazan, Andrew M. Hoffman, Daniel J. Weiss. Stem Cells, 2013, 31(7), 1330-9
Issues Determining Direct Airways Hyperresponsiveness in Mice. Lundblad L.K.A.  Front. Physio. 2012, 3:408.
Riesenfeld E, Allen GB, Bates JH, Poynter ME, Wu M, Aimiand S, and Lundblad LK. The Temporal Evolution of Airways Hyperresponsiveness and Inflammation. Journal of allergy & therapy 1: 1-7, 2012.
Bates JH, Stevenson CA, Aliyeva M, and Lundblad LK. Airway responsiveness depends on the diffusion rate of methacholine across the airway wall. J Appl Physiol (1985) 112: 1670-1677, 2012.
Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of beta-receptor affinity in murine models of asthma. Lennart KA Lundblad, Lisa M Rinaldi, Matthew E. Poynter, Erik P Riesenfeld, Min Wu, Steven Aimi, Leesa M Barone, Jason HT Bates and Charles G Irvin Respiratory Research 2011, 12:27