University of Vermont

College of Medicine

Vermont Lung Center

Bio for Laurie Whittaker Leclair, M.D.
Laurie Whittaker Leclair, M.D.

Laurie Whittaker Leclair, M.D.

Associate Professor of Medicine, Pulmonary Medicine
Department of Medicine


Contact Information
E-mail: Laurie.Whittaker@uvm.edu
Office Location:
Medicine, MFU-Patrick, Rm 311

Education

MD (1992-1996) Tuft’s University School of Medicine, Boston, MA.

BA Chemistry (1988-1992) University of Vermont, Burlington, VT.

Research Interests

Th2 Mediated Airway Inflammation:

• In Cystic Fibrosis
• In Asthma
• Regulators of mucus production

Novel antimicrobial therapies
Microbial interactions in the airway

Academic Appointments

Director, Adult Cystic Fibrosis Center, Fletcher Allen Health Care, (2002-Present) Burlington, VT.

Associate Professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, (2008-2010)

Assistant Professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, (2002-2008) University of Vermont, Burlington, VT.

Publications

Scanlon TC, Teneback CC, Gill A, Bement JL, Weiner JA, Lamppa JW, Leclair LW, Griswold K. Enhanced antimicrobial activity of engineered human lysozyme. ACS Chem Biol. 2010 Jul 6.

Neveu, W, Allard, J, Dienz, O, Ciliberto, G, Wargo, M, Whittaker, LA, Rincon, M. IL-6 is required for airway mucus production induced by inhaled fungal allergens. Journal of Immunology, Volume 183(3)1732-8, 2009.

Wargo MJ, Ho TC, Gross MJ, Whittaker LA, Hogan DA. GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites. Infect Immun. Volume 77(3):1103-11, 2009.

Allard JB, Rinaldi L, Wargo M, Allen GA,  Akira S, Uematsu S, Poynter ME, Hogan DA, Rincon M, Whittaker LA.  Th2 Allergic Immune Response to Inhaled Fungal Antigens is Modulated By TLR-4-Independent Bacterial Products.  EJI.  Volume  39(3): 776-88, 2009.

Allard, J., Poynter, M., Marr, K., Cohn, L., Rincon, M. and Whittaker, L.  Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator. Journal of Immunology. Volume 177: 5186, 2006.