University of Vermont

College of Medicine

Vermont Lung Center

Bio for Yvonne Janssen-Heininger, Ph.D.
Yvonne Janssen-Heininger, Ph.D.

Yvonne Janssen-Heininger, Ph.D.

Professor, Department of Pathology & Laboratory Medicine

Contact Information
Office Location:
Health Science Research Facility 216A


Protein-thiol-redox based Signaling, S-glutathionylation, Airway Epithelial Biology, Asthma, Pulmonary Fibrosis, Transcription Factors: Nuclear Factor Kappa B, death receptors: Fas, Epithelial to Mesenchymal Transition, c-Jun-N-terminal kinase, Fibrosis

Academic Interests

To provide an exciting research environment and extensive mentoring to all laboratory members to enable each of them to be maximally successful in the arena of biomedical sciences in diverse capacities.

Research Interests

To unravel the molecular basis of diverse pulmonary diseases by emphasizing the biology of epithelial cells and redox-dependent processes.

Postdoctoral Training

10/1/93 - 6/30/96 Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT


1993  Ph.D.: Maastricht University, The Netherlands
In alliance with: Maastricht University Medical Center, Di-One Institute
1988  BA/MS - University of Limburg, Maastricht, The Netherlands
Major: Biological Health Sciences, Faculty of Health Sciences

Academic Appointments

2017- Present Vice-Chair for Research, Department of Pathology & Laboratory Medicine,  The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT
2008 - Present Professor, University of Vermont, Department of Pathology, Burlington, VT
1999 - Present Adjunct Professor, Department of Pulmonology University of Maastricht, Maastricht, The Netherlands
2002 - 2008 Associate Professor, University of Vermont, Department of Pathology, Burlington, VT
1997 - 2002  Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1996 - 1997 Research Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1993 - 1996  Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT

Awards and Honors

2014–2016 Elected Chair, Lung Injury Repair and Remodeling Study Section, National Institutes of Health

2010-2016  Member, National Institutes of Health, Lung Injury, Repair and Remodeling Study Section
2010  "J. Walter Juckett Scholar Award", Lake Champlain Cancer Research Organization
2002-2005  Member, National Institutes of Health, Lung Biology and Pathology Study Section
1996-1997  "Senator Proctor Research Award", American Lung Association of Vermont
1996  "JAAP Swierenga Award", Dutch College of Chest Physicians, The Netherlands
1995-1998  "Parker B. Francis Fellowship in Pulmonary Research"
1994  "Thesis Award 1992-1993" Nutrition Toxicology and Environmental Research Institute, Maastricht, The Netherlands


Hoffman SM, Nolin JD, Wouters EFM, Janssen-Heininger YMW, Reynaert NL: Thiol redox chemistry: role of cysteine oxidation and altered redox homeostasis in allergic inflammation and asthma. J Cell Biochem. 116(6):884-92, 2015

Chapman DG, Tully JE, Nolin JD, Janssen-Heininger YM, Irvin CG. Animal models of allergic airways disease: where are we and where to next? J Cell Biochem. 115(12):2055-64, 2014

Li L, Wei C, Kim IK, Janssen-Heininger Y, Gupta S: Inhibition of Nuclear Factor-?B in the Lungs Prevents Monocrotaline-Induced Pulmonary Hypertension in Mice Hypertension 63(6):1260-9, 2014 Epub 2014 Mar 10, PMID: 24614212

Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM. The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor ?B family proteins. Free Radic Biol Med. 73:143-53, 2014 PMCID: PMC4111997

van der Velden JL, Hoffman SM, Alcorn JF, Tully JE, Chapman DG, Lahue KG, Guala AS, Lundblad LK, Aliyeva M, Daphtary N, Irvin CG, Janssen-Heininger YM. Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol. 306(9):L866-75, Epub 2014 PMCID: PMC4010650

For a complete list of Yvonne Janssen-Heininger's publications, please visit PubMed.