University of Vermont

College of Medicine

Vermont Center for Immunobiology and Infectious Diseases

Bio for Oliver Dienz, Ph.D.

Oliver Dienz, Ph.D.

Assistant Professor of Medicine, Immunobiology
Department of Medicine


Contact Information
E-mail: Oliver.Dienz@uvm.edu
Phone:
802-656-4655
Office Location:
Medicine, Immunobiology, C312A Given Bldg., 89 Beaumont Ave., Burlington, Vermont 05405

Education

2002 PhD in natural sciences (Dr. rerum naturum), Thesis entitled “Activation of the transcription factor NF-B by T cell costimulation”. University of Witten/Herdecke, Witten, Germany
1998 Diploma in Biochemistry, College of Chemistry, Ruhr-University Bochum, Bochum, Germany

Research Interests

Inflammatory and CD4 T cell memory response to influenza.
Dr. Dienz studies the memory response to influenza virus infection and how it contributes to viral clearance and inflammation. Immunological memory protects against reinfection with the same pathogen and is often associated with the presence of neutralizing antibodies. Due to its high mutation rate, influenza virus is continuously evolving rendering antibodies generated during previous infections ineffective against new substrains. In addition, the emergence of new strains such as the recent H1N1 "swine flu" can cause pandemics with potentially high morbidity and mortality. While antibodies from previous infections are unable to neutralize the new virus, memory T cells recognize more conserved epitopes and may therefore offer protection even against new pandemic influenza strains. We previously described the pivotal role of the transcription factor NFAT in the effector functions of memory CD4 T cells. We are now investigating how NFAT contributes to viral clearance and whether specific upregulation of NFAT in memory CD4 T cells may be a potential mechanism to enhance vaccine efficacy. Investigating the effector functions of memory CD4 T cells may also help in resolving the paradox that during an influenza pandemic especially young, healthy adults suffer from high morbidity and mortality. It is believed that an exuberant immune response in those individuals promotes excess inflammation and tissue damage. We are studying whether certain effector functions of memory CD4 T cells may contribute to this phenomenon. Since decreasing inflammation may reduce the severity of influenza virus infection, we are also investigating whether treatment with the vitamin A-derivative retinoic acid may reduce lung tissue damage. In a related project, we are collaborating with Drs. Mark Phillippe and Elizabeth Bonney in Ob-Gyn to elucidate the mechanisms responsible for the high mortality seen in pregnant women infected with influenza virus.

Academic Appointments

2010 to present:  Assistant Professor of Medicine (Immunobiology), Department of Medicine
2007 - 2010:  Research Associate in Medicine (Immunobiology), Department of Medicine

Publications

Rud, J. G, Dienz, O., Eaton, S. M., Lanthier, P. A., Burg, E., Drew, A., Bunn, J., Suratt, B. T., Haynes, L., Rincon, M. Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival. Manuscript submitted.

Roberson, E. C., Tully, J. E., Guala, A. S., Reiss, J. N., Godburn, K. E., Pociask, D. A., Alcorn, J. F., Riches, D. W., Dienz, O., Janssen-Heininger, Y. M., Anathy, V. Influenza Induces ER Stress, Caspase-12- Dependent Apoptosis and JNK Mediated TGF-{beta} Release in Lung Epithelial Cells. Am J Respir Cell Mol Biol. 2011 Jul 28. [Epub ahead of print]

Neveu, W. A., Allard, J. B., Dienz, O., Wargo, M. J., Ciliberto, G., Whittaker, L. A., Rincon, M. IL-6 regulates mucus production and antibody response induced by inhaled fungal antigens. J Immunol. 2009 Aug 1;183(3):1732-8.

Dienz, O., Eaton, S. M., Bond, J. P., Neveu, W. A., Moquin, D., Noubade, R., Briso, E. M., Charland, C., Leonard, W. J., Ciliberto, G., Teuscher, C., Haynes, L., Rincon, M. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009 Jan 16;206(1):69-78.

Dienz,O., Rincon, M. The effects of IL-6 on CD4 T cell responses. Clin. Imm. 2009 Jan;130(1):27-33.

To see all of Dr. Dienz's publications, please visit PUB MED