University of Vermont

College of Medicine

Vermont Center for Immunobiology and Infectious Diseases

Bio for Dwight Matthews, Ph.D.
Dwight Matthews, Ph.D.

Dwight Matthews, Ph.D.

Professor of Medicine, Endocrinology, Diabetes and Metabolism Medicine
Department of Medicine
Professor of Chemistry

Contact Information
Office Location:
Chemistry, Cook Physical Sci Bldg A205


Matthews Lab


B.A. - DePauw University, Greencastle, Indiana, May 1973.
Ph.D. - Analytical Chemistry, Indiana University, Bloomington, Indiana, December 1977.

Academic Interests

Mass spectrometry
Stable isotope tracers
Amino acid metabolism
Protein metabolism
Energy metabolism


DE Matthews & JM Hayes: Isotope-ratio-monitoring gas chromatography-mass spectrometry. Anal. Chem. 50: 1465-1473, 1978.
DE Matthews, E Ben Galim & DM Bier: Determination of stable isotopic enrichment in individual plasma amino acids by chemical ionization mass spectrometry. Anal. Chem. 51: 80-84, 1979.
DE Matthews, KJ Motil, DK Rohrbaugh, JF Burke, VR Young & DM Bier: Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-13C]leucine. Am. J. Physiol. Endocrinol. Metab. 238: E473-E479, 1980.
DE Matthews, DM Bier, MJ Rennie, RHT Edwards, D Halliday, DJ Millward & GA Clugston: Regulation of leucine metabolism in man: A stable isotope study. Science 214: 1129-1131, 1981.
DE Matthews, MA Marano & RG Campbell: Splanchnic bed utilization of leucine and phenylalanine in humans. Am. J. Physiol. Endocrinol. Metab. 264: E109-E118, 1993.
ME Jennings, II & DE Matthews: Determination of complex isotopomer patterns in isotopically labeled compounds by mass spectrometry. Anal. Chem., 77: 6435-6444, 2005.

MJ MacCoss & DE Matthews: Quantitative mass spectrometry for proteomics: Teaching a new dog old tricks. Anal. Chem. 77: 294A-302A, 2005.

DE Matthews: Observations of branched-chain amino acid administration in humans. J. Nutr. 135: 1580S-1584S, 2005.

MJ Toth, DE Matthews, PA Ades, MD Tischler, P Van Buren, MJ Previs & MM LeWinter: Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity. Am. J. Physiol. Endocrinol. Metab. 288: E685-E692, 2005.

MJ Toth, DE Matthews, RP Tracy & MJ Previs: Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am. J. Physiol. Endocrinol. Metab. 288: E883-E891, 2005.

JA Henkin, ME Jennings, DE Matthews & JO Vigoreaux: Mass processing--an improved technique for protein identification with mass spectrometry data. J. Biomol. Tech. 15: 230-237, 2004.

CC Wu, MJ MacCoss, KE Howell, DE Matthews &JR Yates, III: Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal. Chem. 76: 4951-4959, 2004.

A Battezzati, A Caumo, F Martino, LP Sereni, J Coppa, R Romito, M Ammatuna, E Regalia, DE Matthews, V Mazzaferro &L Luzi: Nonhepatic glucose production in humans. Am. J. Physiol. Endocrinol. Metab. 286: E129-E135, 2004.

M Rosenbaum, K Vandenborne, R Goldsmith, JA Simoneau, S Heymsfield, DR Joanise, J Hirsch, E Murphy, D Matthews, KR Segal & RL Leibel: Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R183-R192, 2003.

R Persinger, Y Janssen-Heininger, SS Wing, DE Matthews, MM LeWinter & MJ Toth: Effect of heart failure on the regulation of skeletal muscle protein synthesis, breakdown, and apoptosis. Am. J. Physiol. Endocrinol. Metab. 284: E1001-E1008, 2003.

Selected Recent Publications: