University of Vermont

College of Medicine

Vaccine Testing Center

About Us

About Us

Message from the Director

The Vaccine Testing Center and Kirkpatrick Laboratory are dedicated to improving global health through the development and study of new vaccines and increased knowledge of the human immune response to infections and vaccines.

 
 
Vaccine Development

Our team runs a fully functioning unit for performing phase I and II vaccine trials and enteric challenge models at the Vaccine Testing Center (VTC). In general, the VTC focuses on the development of vaccines of importance to global health, including typhoid fever, Campylobacter infections, dengue virus infections, cholera, rotavirus and polio infections. In 2009, the VTC began a 10-year project with Johns Hopkins and the National Institutes of Health's Laboratory of Infectious Diseases to study new Dengue vaccines. Other collaborators have included biotech companies, the National Institutes of Health and the Department of Defense.

Our laboratories are outfitted for scaled-up clinical immunology and microbiology work. Our staff is trained in current Good Clinical Practices (GCP) according to FDA E9 specifications and the laboratory operates on Good Clinical Laboratory Practice (GCLP) principles. Laboratories have the capacity for performing the immunogenicity work for multi-site vaccine trials, including specimen processing and storage. We also have the flexibility to add study-specific assays needed for vaccine trials. A detailed description of available equipment is available upon request. Experienced technicians are trained to perform validated immunologic and microbiology assays including: ELISAs, ELISPOT/ ASC/ ALS assays, functional assays of opsonization, PCR, multi-parameter flow cytometry and cell sorting, cytokine analysis (Bioplex), confocal microscopy, plaque-based assays for viral pathogens, bacterial culturing, and inoculum preparation for challenge studies.

Infectious Disease Immunology

In addition to vaccine testing, the lab is interested in characterizing how the human host responds immunologically to clinically important infectious agents and vaccines. The goal of this work is to gain a better understanding of immunologic responses to vaccines as well as natural infections.

For details about recruitment for ongoing studies see Volunteer for Research.

Beth Kirkpatrick, M.D.

Professor of Medicine
Director, Vaccine Testing Center

Last modified December 18 2013 03:18 PM