University of Vermont

College of Medicine

Toth Laboratory

volunteer

Interested in volunteering for a research study?

We currently have three on-going studies in the laboratory that are actively recruiting volunteers.

Title: Skeletal muscle contractile dysfunction in chronic heart failure
Funding: National Heart, Lung and Blood Institute, Dept of Health and Human Services

This goal of this research study is to determine how chronic heart failure contributes to impaired skeletal muscle function. Research has shown that hear failure is accompanied by adaptations in peripheral skeletal muscle that diminish the capacity to perform activities of daily living. One major adaptation that occurs is a loss of skeletal muscle strength. We are studying individuals with stable, chronic heart failure and sedentary, healthy controls with no history of cardiac disease. Both patients with heart failure and controls undergo evaluations of muscle function and then enter an exercise training program to evaluate the influence of resistance exercise (ie, weight training) on their muscle function. If you are interested in receiving more information about this study, please contact Patrick Savage at (802) 847-4545 or patrick.savage@vtmednet.org.

Title: Muscle disuse and contractile dysfunction in the elderly
Funding: National Institute on Aging, Dept of Health and Human Services

This goal of this research study is to understand how muscle disuse causes muscle to get weaker and not function properly. Research has shown that individuals with knee osteoarthritis have very low levels of physical activity (ie, experience muscle disuse), due to joint pain caused by the osteoarthritis. Thus, individuals with advanced knee osteoarthritis can be used as a model population that experiences profound, protracted muscle disuse. We are studying individuals with advanced knee osteoarthritis and comparing them to elderly controls with no evidence of knee osteoarthritis and normal activity levels. Volunteers with knee osteoarthritis will also undergo an exercise training program to remediate muscle disuse to determine whether impairments in muscle function can be corrected. Eligible individuals are 60-80 yrs of age and do not have a history of chronic cardiac, lung, kidney, liver or autoimmune disease. A more detailed description of this study can be found here. If you are interested in receiving more information about this study, please contact Patrick Savage at (802) 847-4545 or patrick.savage@vtmednet.org.

Title: Translational studies of muscle atrophy/dysfunction in individuals with cancer cachexia
Funding: UVM College of Medicine

Our laboratory is collaborating with our colleagues in the Division of Hematology and Oncology on this study (Drs. Dittus (Principal investigator), Grunberg and Couch). The goal of this research study is to understand the mechanisms underlying muscle atrophy and contractile dysfunction in patients with cancer cachexia. Researh has shown that cancer cachexia, like other chronic diseases, is associated with a loss of muscle size and strength that may be explained, in large part, by a loss of the contractile protein myosin (Acharyya et al. 2004; Schmitt et al. 2007). Clear proof that this phenotype exists in human cancer and the mechanisms underlying the loss of myosin, however, is lacking. We are studying indivduals with lung, panceatic, and gastrointestinal cancer. If you, or someone you know, might be interested in participating, please contact Jasmine Hamerslough at (802) 656-9794 or jasmine.hamerslough@med.uvm.edu.

*IMPORTANT*

The most important aspect of your participation in our research is that you are well-informed and feel comfortable with your decision to participate. Thus, we refer you to information provided by the CDC and NIH, as well as our local UVM Ethical Review Board, to provide you with resources that can assist you in the decision-making process.

Last modified December 18 2013 02:48 PM