Recent research:
We have shown that resistance exercise training reduces physical disability in patients with chronic heart failure and have identified alterations at the cellular and molecular levels that may partially explain these improvements.
Toth Laboratory
Translational Studies of Human Skeletal Muscle
Our studies evaluate skeletal muscle structure, function and metabolism at the whole body, tissue, single cell and molecular level in humans using a variety of research techniques. The focus of these studies is to understand the effects of:
- chronic disease,
- muscle disuse and
- aging.
Our long-range goal is to understand the cellular and molecular mechanisms whereby these conditions regulate skeletal muscle size, metabolism and function and the potential utility of therapeutic interventions to counter physical disability.
Chronic disease
On-going projects strive to understand how chronic disease in the elderly impairs muscle function and the utility of resistance exercise to correct these defects.
Muscle disuse
On-going projects seek to determine in elderly volunteers how skeletal muscle adapts to chronic muscle disuse and the remedial effects of resistance exercise training.
Aging
On-going projects with our collaborators focus on defining how aging affects skeletal muscle functionality at the whole muscle, single fiber and molecular levels.
Last modified August 16 2012 04:08 PM
