University of Vermont

College of Medicine

Department of Surgery

Bio for Stephanie C. Pero, Ph.D.
Stephanie C. Pero, Ph.D.

Stephanie C. Pero, Ph.D.

Assistant Professor
Department of Surgery


Contact Information
E-mail: Stephanie.Pero@uvm.edu
Office Location:
Dept of Surgery, Given E310

Education

M.S., Biology Worcerster Polytechnic Institute, Worcester, MA (1997)
Ph.D., Cell and Molecular Biology, University of Vermont College of Medicine, Burlington, VT (2002)

Academic Appointments

Assistant Professor, Department of Surgery, College of Medicine, University of Vermont, Burlington, VT, 2006 - present

Publications

Boivin B, Chaudhary F, Dickinson BC, Haque A, Pero SC, Chang CJ, Tonks NK. Receptor protein-tyrosine phosphatase a regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility. J Biol Chem. 2013 Dec 27;288(52):36926-35.

Shukla GS, Krag DN, Peletskaya EN, Pero SC, Sun YJ, Carman CL, McCahill LE, Roland TA. Intravenous infusion of phage-displayed antibody library in human cancer patients: enrichment and cancer-specificity of tumor-homing phage-antibodies. Cancer Immunol Immunother. 2013 Jun 5. [Epub ahead of print]

Sun Y, Shukla G, Pero SC, Currier E, Sholler G, Krag D. Single tumor imaging with multiple antibodies targeting different antigens. Biotechniques. 2012;0(0):1-3.

Gunzburg MJ, Ambaye ND, Del Borgo MP, Pero SC, Krag DN, Wilce MC, Wilce JA. Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity. J Mol Recognit. 2012;25(1):57-67.

Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA, Kenny PA. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012;133(2):607-15.

Ambaye ND, Pero SC, Gunzburg MJ, Yap M, Clayton DJ, Del Borgo MP, Perlmutter P, Aguilar MI, Shukla GS, Peletskaya E, Cookson MM, Krag DN, Wilce MC, Wilce JA. Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression. J Mol Biol. 2011;412(3):397-411.

Ambaye ND, Lim RC, Clayton DJ, Gunzburg MJ, Price JT, Pero SC, Krag DN, Wilce MC, Aguilar MI, Perlmutter P, Wilce JA. Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain. Biopolymers. 2011;96(2):181-8.

Gur D, Liu S, Shukla A, Pero SC, Wicha MS, Krag DN. Identification of single chain antibodies to breast cancer stem cells using phage display. Biotechnol Prog. 2009;25(6):1780-7.

Sun Y, Shukla GS, Weaver D, Pero SC, Krag DN. Phage-display selection on tumor histological specimens with laser capture microdissection. J Immunol Methods. 2009;347(1-2):46-53.

Sun Y, Shukla GS, Kennedy GG, Warshaw DM, Weaver DL, Pero SC, Floyd L, Krag DN. Biopanning Phage-Display Libraries on Small Tissue Sections Captured by Laser Capture Microdissection. J Biotech Res. 2009;1:55-63.

Li P, Jiang S, Pero SC, Oligino L, Krag DN, Michejda CJ, Roller PP. Design and synthesis of paclitaxel conjugated with an ErbB2-recognizing peptide, EC-1.  Biopolymers, 2007;87(4): 225-30.

Porter CJ, Matthews JM, Mackay JP, Pursglove SE, Schmidberger JW, Leedman PJ, Pero SC, Krag DN, Wilce MC, Wilce JA.  Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.  BMC Struct Biol, 2007;7(1):58.

Pero SC, Shukla GS, Cookson MM, Flemer S Jr, Krag, D.N. Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab  (Herceptin) results in cooperative cell growth inhibition in breast cancer cells.  Br J Cancer,  2007;96(10):1520-5.

Spuches AM, Argiros HJ, Lee KH, Haas LL, Pero SC, Krag DN, Roller PP, Wilcox DE, Lyons BA.  Calorimetric investigation of phosphorylated and non-phosphorylated peptide ligand binding to the human Grb7-SH2 domain.  J Mol Recognit, 2007;20(4): 245-52.

Krag DN, Shukla GS, Shen GP, Pero S, Ashikaga T, et al, Selection of tumor-binding ligands in cancer patients with phage display libraries.  Cancer Res, 2006;66(15): 7724-33.