Department of Surgery : University of Vermont

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Department of Surgery

Bio for Brian Sprague, Ph.D.

Brian Sprague, Ph.D.

Assistant Professor of Surgery
Department of Surgery

Contact Information

E-mail: Brian.Sprague@uvm.edu
Phone: 802-656-4112
Office Location: UHC Rm 4425, 1 S. Prospect Street

Education

M.S., Biomedical Engineering, University of Minnesota, twin Cities, MN, 2002
Ph.D., Population Health Sciences (Concentration in Epidemiology), University of Wisconsin, Madison, WI, 2009
Postdoctoral Fellow, University of Wisconsin, Department of Population Health Sciences (2009-2010)

Academic Appointments

Assistant Professor, Department of Surgery, College of Medicine, University of Vermont, Burlington, VT, 2010 - present

Research Interests

Breast Cancer Epidemiology
Breast Cancer Screening
Ductal Carcinoma in Situ
Mammographic Breast Density

Research Grants

Co-Principal Investigator. Vermont PROSPR Research Center (U54 CA163303; Principal Investigator Berta Geller). National Cancer Institute; 2011-2016; $6.5 million total costs. Project leader for “Breast density and collagen alignment as predictors of DCIS diseasefree survival”; $619,612 total project costs.

Co-Investigator. Risk-Based Breast Cancer Screening in Community Settings (P01CA154292- 01A1; Subcontract to Group Health Research Institute, Principal Investigator Diana Miglioretti). National Cancer Institute; 2011-2016; $227,769 total UVM costs.

UVM Principal Investigator. Comparative Modeling: Informing Breast Cancer Control Practice & Policy (U01
CA152958; Subcontract to University of Wisconsin, Principal Investigator Jeanne Mandelblatt). National Cancer Institute; 2010-2015; $81,461 total UVM costs.

Co-Principal Investigator. The influence of inflammation on breast cancer risk. Fletcher Allen Health Care/University of Vermont Medical Group Research Award Program; 2012-2014; $49,997 total costs.

UVM Principal Investigator. Tumor microenvironment and progression to invasion after a diagnosis of ductal carcinoma in situ (BC102357; Subcontract to University of Wisconsin, Principal Investigator Amy Trentham-Dietz). Department of Defense Breast Cancer Research Program; 2011-2013; $28,097 total UVM costs.

UVM Principal Investigator. Breast Cancer Surveillance Consortium Data Resource (HHSN26120110031C; Subcontract to Group Health Research Institute, Principal Investigator Diana Miglioretti). National Cancer Institute; 2011-2012; $43,047 total UVM costs.

Principal Investigator. Modifiable risk factors for second breast cancer events after diagnosis of ductal carcinoma in situ (PCF-0596). American Society of Preventive Oncology Research Fellowship with funding from the Prevent Cancer Foundation and the Susan Komen Foundation; 2010-2012; $54,054 total costs.

UVM Principal Investigator. The Vitamin D Pathway and Mammographic Breast Density in Postmenopausal Women (R03 CA139548; Subcontract to University of Wisconsin, Principal Investigator Amy Trentham-Dietz). National Cancer Institute; 2011-2012; $17,829 total UVM costs.

Awards and Honors

Scholar-in-Training Travel Award, American Association for Cancer Research, 2009
Cancer Prevention Research Fellowship, American Society of Preventive Oncology/Prevent Cancer Foundation, 2009

Publications

Sprague BL, Trentham-Dietz A, Cronin KA. A sustained decline in postmenopausal hormone use: results from the National Health and Nutrition Examination Survey, 1999-2010. Obstet Gynecol 2012;120(3):595-603.

Lowry SJ, Sprague BL, Aiello Bowles EJ, Hedman CJ, Hemming J, Hampton JM, Burnside ES, Sisney GA, Buist DS, Trentham-Dietz A. Mammographic breast density and serum phytoestrogen levels.Nutr Cancer 2012;64(6):783-9.

Nichols HB, Sprague BL, Buist DS, Erwin DO, Leach CR, Patrick H. Careers in cancer prevention: what you may not see from inside your academic department--a report from the American Society of Preventive Oncology's Junior Members Interest Group. Cancer Epidemiol Biomarkers Prev. 2012;21(8):1393-5.

Sprague BL, Trentham-Dietz A, Gangnon RE, Buist DS, Burnside ES, Aiello Bowles EJ, Stanczyk FZ, Sisney GS, Skinner HG. The vitamin D pathway and mammographic breast density among postmenopausal women. Breast Cancer Res Treat. 2012;131(1):255-65.

Sprague BL, Thompson CL, Ganz PA, Kanetsky PA, Kushi LH, Nebeling L. The business of research: budgets, personnel, planning, and pitfalls--a report from the American Society of Preventive Oncology's Junior Members Interest Group. Cancer Epidemiol Biomarkers Prev 2011;20(8):1802-4.

Sprague BL, Trentham-Dietz A, Gangnon RE, Ramchandani R, Hampton JM, Robert SA, Remington PL, Newcomb PA. Socioeconomic status and survival after an invasive breast cancer diagnosis. Cancer 2011;117(7):1542-51.

Sprague BL, Trentham-Dietz A, Gangnon RE, Buist DS, Burnside ES, Bowles EJ, Stanczyk FZ, Sisney GS.
Circulating sex hormones and mammographic breast density among postmenopausal women. Horm Cancer. 2011 Feb;2(1):62-72.

Sprague BL, Trentham-Dietz A, Remington PL. The contribution of postmenopausal hormone use cessation to the declining incidence of breast cancer. Cancer Causes Control 2011;22(1):125-34.

Sprague BL, Trentham-Dietz A. In situ Breast Cancer. In: Breast Cancer Epidemiology, Li
CI (ed), New York: Springer, 2010:47-72.

Sprague BL, Trentham-Dietz A, Nichols HB, Hampton JM, Newcomb PA. Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ. Breast Cancer Research and Treatment 2010;124(2):487-495.

Sprague BL, Trentham-Dietz A, Burnside ES. Socioeconomic disparities in the decline in invasive breast cancer incidence. Breast Cancer Research and Treatment 2010;122(3):873-878.

Sprague BL, Skinner HG, Trentham-Dietz A, Lee KE, Klein BEK, Klein R. Serum calcium and breast cancer risk in a prospective cohort study. Annals of Epidemiology 2010;20(1):82-85.

Gardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJ. Model convolution: a computational approach to digital image interpretation. Cellular and Molecular Bioengineering 2010;3(2):163-170.

Sprague BL, Trentham-Dietz A. Prevalence of breast carcinoma in situ in the United States. JAMA 302(8):846-848, 2009.

Complete List of Publications