University of Vermont

College of Medicine

Program in Integrative Health

Bio for Helene Langevin, M.D.
Helene Langevin, M.D.

Helene Langevin, M.D.

Professor
Department of Neurological Sciences


Contact Information
E-mail: Helene.Langevin@uvm.edu
Phone:
802-656-1001
Office Location:
University of Vermont, College of Medicine, 89 Beaumont Ave., Given C423, Burlington, Vermont 05405

Website

Lab: http://www.uvm.edu/medicine/neuro/?Page=langevin_lab.html

Education

1986-1988: Acupuncture schools attended: Tristate Institute of Acupuncture, Stamford, Connecticut and Worsley School of Traditional Chinese Acupuncture, Leamington Spa, England, and Miami, Florida
1985-1986:  Endocrinology and Metabolism Fellow, Johns Hopkins Hospital and Sinai Hospital Baltimore, Maryland
1982-1985:  Intern and Resident in Internal Medicine, Johns Hopkins Hospital, Baltimore, Maryland 
1978-1981: Neuroanatomy and Neurochemistry, MRC Neurochemical Pharmacology Unit, Cambridge, England
1978:  MD, McGill University, Montreal, Canada

Research Interests

My research program centers on the role of connective tissue in chronic pain and in the mechanisms of acupuncture, manual and movement-based therapies (e.g. massage, yoga). My studies have shown that mechanical tissue stimulation during both tissue stretch and acupuncture causes dynamic cellular responses in connective tissue.  We also have shown that connective tissue fibroblasts actively participate in the regulation of connective tissue tension, and that connective tissue is abnormal in human subjects with chronic low back pain. Using a rodent model of connective tissue inflammation in the low back, my research group also showed that in vivo stretching can improve gait, mechanical sensitivity and local connective tissue inflammation. An ongoing project in pigs is investigating whether movement restriction can worsen connective tissue inflammation and whether the effects of movement restriction can be reversed by stretching. 

Publications

Langevin HM, Fox JR, Koptiuch C, Badger GJ, Greenan-Naumann AC, Bouffard NA, Konofagou EE, Lee W, Triano JJ, Henry SM. Reduced thoracolumbar fascia shear strain in human chronic low back pain. BMC Musculoskeletal Disorders 2011 (In Press).

Corey S, Vizzard M, Badger G, and Langevin H. Sensory innervation of the non-specialized connective tissues in the low back of the rat. Cells, Tissues, Organs 2011 Mar 18.

Langevin HM, Bouffard NA, Fox JA, Palmer BM, Wu J, Iatridis JC, Barnes WD, Badger GJ, Howe AK. Fibroblast cytoskeletal remodeling contributes to connective tissue tension. Journal of Cellular Physiology. May 2011; 226(5):1166-75. doi:10.1002/jcp.22442.

Berman BM, Langevin HM, Witt CM, Dubner R. Acupuncture for Chronic Low Back Pain. New England Journal of Medicine 363: 454-61, 2010.

Ahn AC, Park M, Shaw JR, McManus CA, Kaptchuk TJ, Langevin HM.  Electrical Impedance of Acupuncture Meridians: the Relevance of Subcutaneous Collagenous Bands. PLoS ONE 5(7):e11907, 2010.

To see more of Dr. Langevin's publications, please visit PubMed.